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The researchers Rafael Franco, from the Institute of Biomedicine of the University of Barcelona, and Eva Martínez Pinilla from the University of Oviedo (Photo: UB).

Boosting natural detoxification pathways in the body to reduce cellular oxidative stress

Promoting innate detoxification mechanisms in the body and discovering which supplements increase the efficacy of those biochemical pathways could be an efficient strategy to reduce the cellular oxidative stress and protect our health, according to an article published in the journal Food Chemistry, by the researchers Rafael Franco, from the Institute of Biomedicine of the University of Barcelona at the Barcelona Science Park and Eva Martínez Pinilla, from the Institute of Neurosciences of Asturias (INEUROPA) and the University of Oviedo.


According to the new study, which analyses scientific information on the metabolism and health under the perspective of chemical laws, antioxidant properties in the molecules of in vitro testings do not seem to be a good indicator of their in vivo activity. According to Professsor Rafael Franco, member of the Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), “living beings that live in an environment rich in Earth’s atmosphere oxygen survive thanks to chemical reactions –mostly reduction-oxidation or REDOX reactions- which are not significantly affected by antioxidant molecules”.

Oxidative stress and free radicals have been related to the origins of some chronic diseases and ageing processes. “The main factor that contributes to increase the oxidative stress in cells unespecifically is age”, says Rafael Franco. “Age affects negatively the efficiency of some detoxification mechanisms, and this would be the same mechanism that occurs in some diseases in which the production of the necessary compounds to maintain the rhythm of detoxification cycles is involved. The oxidative stress is caused by a deficiency in detoxification mechanisms and the simple consume of antioxidants cannot reverse this fact”. 

The article, published in the journal Food Chemistry, analyses the main mechanisms to palliate the effects of cellular oxidative stress, developed by mammals over evolution. Out of these detoxification mechanisms, the most known one is the one of blood cells, based on glutathione –a tripeptide that would act as a powerful natural antioxidant- and the action of glucose-6-phosphate dehydrogenase (G6PDH), which creates another important antioxidant, NADPH, a basic co-enzyme in the cellular metabolism. 

More information: UB website [+]

► Reference article: 
Franco, R. i Martínez-Pinilla, E. “Chemical rules on the assessment of antioxidant potential in food and food additives aimed at reducing oxidative stress and neurodegeneration“. Food Chemistry, maig de 2017. Doi: 10.1016/j.foodchem.2017.05.040