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maig 12 @ 12:00 - 13:30
Spatio-temporal regulation of RNA condensates in the aging brain
Speaker: Dr. Florence Besse – Director & Group Leader , Institut de Biologie Valrose (iBV)| Nice, France.
Neurons rely on macro- and micro-cellular compartmentalization to rapidly process information, and locally respond to external stimuli. By mediating the transport of RNAs to axons or dendrites, and by tightly regulating their translation in space and time, neuronal ribonucleoprotein (RNP) granules play a crucial role in such a subcellular organization. How these condensates enriched in RNA molecules and associated regulatory proteins respond to physiological stimuli to promote neuronal functions in the context of intact circuits has however remained unclear.
We study neuronal RNP granules that assemble in Drosophila CNS neurons and are transported to the axons of neurons involved in learning and memory. By combining functional approaches, live-imaging and biochemical purifications, our group is exploring the mechanisms underlying both long-distance transport of RNP granules and remodeling in response to aging.
IRB BioMed Seminars
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