- Aquest esdeveniment ja ha passat.
20 novembre 2023 @ 15:30 - 17:30
Mining immunomodulatory myeloid programs in cancer
Speaker: Maria Casanova-Acebes, PhD. – Junior Group Leader – Cancer Immunity laboratory – Spanish National Cancer Research Center (CNIO) | Madrid, Spain.
Myeloid cells dominate solid tumors yet due to their inherent plasticity; we have not succeeded at their effective targeting in cancer. This is worrisome because while novel immune checkpoint blockers arise in other immune lineages, myeloid cells are in urgent need of effective therapies to dampen their immunosuppressive role in tumors. But well, are these cells uniquely regulating immunosuppression in the tumor microenvironment (TME)? Can we functionalize all the efforts already made from single-cell technologies mapping this compartment?
Her laboratory focuses on understanding HOW and WHEN myeloid cells become relevant in the TME of solid tumors. By asking how they crosstalk with key cellular and non-cellular players in transformed tissues, they aim to identify effective and durative ways of impeding their pathogenic program in tumors. During her talk, She will go over some published (to set the stage) and unpublished data in which: 1) I will pitch on the role of alveolar macrophages modulating the stroma of lung tumors; 2) provoke the audience with exciting data on circadian rhythms in the lung TME (and how myeloid cells modulate those!->this is our WHEN angle) and finally, 3) introduce exciting data on how clonal hematopoiesis impacts the outcome of ovarian tumors and macrophage inflammatory and lipid metabolic activity.