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28 juny 2022 @ 15:00 - 17:00

IBMB Seminars: Temporal Crontol of Neurogenesis

Speaker: Bassem Hassan, PhD.

Scientific Director and Deputy General Director at the
Institut du Cerveau – Paris Brain Institute (PBI).

An important manifestation of time during neurogenesis is the generation of different types of neurons from the same pool of progenitors over time. This means that neural progenitors can decode time and convert it into discrete quanta of different neuronal fates. However, for progenitors to decode time into discrete quanta, it must be true that total time is somehow genetically encoded. The extension and retraction of this total neurogenic time in closely related species is associated with changes in brain size, often without significant changes to neuronal fate. However, the genetic mechanisms that translate total time into neuronal numbers are not well understood. Previous work from the lab suggests that transcription factors known as proneural proteins are good candidates for this link: altering the timing of proneural protein expression or activity alters the size of the neuronal lineages they produce. Conversely, changes the total time of neurogenesis alters proneural gene expression. These observations suggest an intimate mechanistic link between timing, transcriptional regulation and brain size.

Mostra els detalls

Data:
28 juny 2022
Hora:
15:00 - 17:00
Lloc web:
https://www.ibmb.csic.es/en/seminars/ibmb-seminar-tuesday-june-28th-300-pm-bassem-hassan-phd/

Organitzador

IBMB
Telèfon
934 034 668
Correu electrònic
contact@ibmb.csic.es
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Recinte

Edifici Cluster I, Aula Fèlix Serratosa
C/ Baldiri Reixac 10-12
Barcelona, Barcelona 08028 Espanya
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Telèfon
934037171
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