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5 octubre 2022 @ 10:00 - 12:00

Differential migration mechanics and immune response of glioblastoma subtypes

Dear all,

The next IBEC Seminar will take place on Wednesday 05th October at 10:00, when David Odde, from Department of Biomedical Engineering at University of Minnesota, will be talking about “Differential migration mechanics and immune response of glioblastoma subtypes”.

David Odde, Department of Biomedical Engineering at University of Minnesota

Glioblastoma remains a deadly cancer driven by invasion of tumor cells into the brain. Transcriptomic analyses have revealed distinct molecular subtypes, but mechanistic and targetable differences that explain clinical differences are not clear. Using a state-of-the-art immunocompetent mouse model for glioblastoma – where tumors are induced by injection of plasmids containing human glioblastoma subtype-defining genetic drivers in a wild-type background – we found that, as predicted by the motor-clutch model for cell migration (Klank et al., Cell Rep, 2017), mesenchymal glioma cells are more spread, generate larger traction forces, and migrate faster in brain tissue compared to proneural cells. Despite their fast migration and comparable proliferation rate in vitro, mice with mesenchymal tumors live longer than mice with proneural tumors, which was correlated with an immune response in the mesenchymal mice that included T cell-mediated killing of cancer cells, similar to human tumors. Thus, mesenchymal tumors have aggressive migration, but are relatively immunologically ‘hot’ which suppresses net proliferation, features which are captured by our Brownian Dynamics tumor simulator (Klank et al., Conv Sci Phys Oncol, 2018). These two features counteract each other and may explain the lack of a strong survival difference between subtypes clinically, while also opening up new opportunities for subtype-specific therapies.

Details

Date:
5 octubre 2022
Time:
10:00 - 12:00
Event Category:
Website:
https://ibecbarcelona.eu/event/ibec-seminar-david-odde/

Organizer

IBEC – Institut de Bioenginyeria de Catalunya

Venue

Edifici Torres R+D+I, Torre I Planta 11
C/ Baldiri Reixac 4-8
Barcelona, Barcelona 08028 Espanya
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