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març 24 @ 12:00 - 13:00
Decoding and Intercepting ER Stress Signals for Cancer Immunotherapy
Speaker: Juan R. Cubillos-Ruiz, Ph.D. The William J. Ledger, M.D., Associate Professor for Infection and Immunology in OBGYN. Associate Professor of Immunology and Microbial Pathogenesis. Co-Leader, Cancer Biology Research Program.
Meyer Cancer Center. Weill Cornell Medicine – Cornell University. New York, USA.
The tumor microenvironment provokes endoplasmic reticulum (ER) stress in malignant cells and infiltrating immune populations. Sensing and responding to ER stress is coordinated by the unfolded protein response (UPR), an integrated signaling pathway governed by three ER stress sensors: ATF6, IRE1α, and PERK. Dysregulated UPR activation in cancer has been shown to dictate malignant progression, tumor growth, metastasis, and protective anti-tumor immunity. Hence, therapies targeting the UPR can be harnessed to elicit direct tumor killing and concomitant anti-cancer immunity. This seminar highlights multiple research efforts from our laboratory that revealed the key immunomodulatory function of ER stress signaling in cancer.