Heart failure is the leading cause of human death worldwide. This is in large part due to the extremely limited turnover of cardiomyocytes in the adult human heart, which is insufficient for substantial regeneration of the damaged myocardium after a heart attack. Unlike humans, zebrafish and other lower vertebrates retain cardiomyocyte proliferative ability in adult life, being able to efficiently regenerate lost myocardium after injury. Why lower vertebrates maintain cardiomyocyte proliferation capacity throughout life whereas mammals lose it soon after birth is largely unknown. Previous work from our group, which centered on studies with zebrafish and newborn mice, indicates that telomeres are critical regulators of cardiomyocyte proliferation and heart regeneration in these animals (1). I will present our past and ongoing research efforts in defining the role of telomerase and telomere length in heart regeneration. Through these efforts, we hope to achieve a more complete knowledge of this process, which could lead to future therapeutic approach for the treatment of heart failure.
(1) Bednarek et al. Cell Rep. 2015; Aix et al, J. Cell Biol. 2016; Aguado T et al, Stem Cells, 2017.
Cell and Developmental Biology Programme Seminar
Data i hora d'inici: 05/07/2017, 15.00h
Data i hora de fi: 05/07/2017, 17.00h
Organitzador: IRB - Institut de Recerca Biomèdica
Lloc: Edifici Clúster Laboratoris, Aula Félix Serratosa
Host: Marco Milán, IRB Barcelona