In the last years, a number of lung epithelial cells have been identified to function as adult stem cells. Depending on the anatomical location and the context specific cell populations have been shown to contribute to the maintenance of tissue homeostasis, or to the repair of the damaged tissue after injury.
During my postdoc at MGH/Harvard Stem Cell Institute (Boston, USA) I have studied the role of airway stem cells in tissue homeostasis, regeneration and disease. As a result of these studies, I have identified a novel mechanism of cell regulation necessary to maintain tissue homeostasis, I have defined the functional segregation of the airway stem/progenitor cell population during airway regeneration and I have described the role of airway stem cells in the initiation of an allergen-induced immune response and the molecular mechanism involved in the development of mucous cell metaplasia observed in asthma, COPD and cystic fibrosis.
In this seminar I'll present all of the aforementioned discoveries and I'll introduce the new line of investigation that we are initiating at CIMA (Pamplona, Spain) since I joined as a PI one year ago and that is focused on studying the role of lung stem cells in pulmonary fibrosis.
Molecular Medicine Programme Seminar
Data i hora d'inici: 05/07/2017, 13.00h
Data i hora de fi: 05/07/2017, 15.00h
Organitzador: IRB - Institut de Recerca Biomèdica
Lloc: Edifici Torres R+D+I, TD Auditori Antoni Caparrós
Host: Manuel Serrano - IRB Barcelona