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X-WR-CALNAME:Parc Científic de Barcelona
X-ORIGINAL-URL:https://www.pcb.ub.edu
X-WR-CALDESC:Esdeveniments per Parc Científic de Barcelona
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TZID:Europe/Madrid
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DTSTART:20210328T010000
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DTSTART:20211031T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220603T120000
DTEND;TZID=Europe/Madrid:20220603T140000
DTSTAMP:20220630T154435Z
CREATED:20220520T084143Z
LAST-MODIFIED:20220630T154435Z
UID:74488-1654257600-1654264800@www.pcb.ub.edu
SUMMARY:Myeloid cells: friends or foes in the tumor microenvironment?
DESCRIPTION:Speaker: María Casanova Acebes\, PhD – GL Cancer Immunity Group – CNIO.
URL:https://www.pcb.ub.edu/esdeveniment/myeloid-cells-friends-or-foes-in-the-tumor-microenvironment/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
CATEGORIES:Esdeveniment PCB
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/05/1-2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220608T160000
DTEND;TZID=Europe/Madrid:20220608T170000
DTSTAMP:20220630T154458Z
CREATED:20220608T082345Z
LAST-MODIFIED:20220630T154458Z
UID:74751-1654704000-1654707600@www.pcb.ub.edu
SUMMARY:Stephanie K. Marrus\, Starting a Life Sciences/Healthcare Company in Silicon Valley
DESCRIPTION:The Innovation Department invites you to meet our guest speaker Stephanie K. Marrus\, Managing Director of Entrepreneurship at University of California San Francisco (UCSF)\, the leading science and medical graduate university in the US and sister school to UC Berkeley. \nStephanie has a deep network (among life science investors\, serial entrepreneurs\, accelerators\, founders\, attorneys and consultants). She leads a global virtual entrepreneurship course. She will share her experience in “Starting a Life Sciences/Healthcare Company in Silicon Valley”.
URL:https://www.pcb.ub.edu/esdeveniment/stephanie-k-marrus-starting-a-life-sciences-healthcare-company-in-silicon-valley/
LOCATION:Edifici Cluster II\, Sala Dolors Aleu\, Avinguda Dr. Marañón 6-8\, Barcelona\, Barcelona\, 08028
CATEGORIES:Esdeveniment PCB
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/06/valley2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220609T100000
DTEND;TZID=Europe/Madrid:20220611T150000
DTSTAMP:20220630T154529Z
CREATED:20220526T085950Z
LAST-MODIFIED:20220630T154529Z
UID:74643-1654768800-1654959600@www.pcb.ub.edu
SUMMARY:Jornada de Portes Obertes 2022
DESCRIPTION:A la jornada de portes obertes de l’IRB Barcelona gaudiràs i formaràs part de la ciència a través de diverses activitats a l’aire lliure i a les nostres instal·lacions\, per a totes les edats.
URL:https://www.pcb.ub.edu/esdeveniment/jornada-de-portes-obertes-2022/
LOCATION:Parc Científic de Barcelona\, Recepció Cluster II\, Av. Dr. Marañón 8\, Barcelona\, Barcelona\, 08028\, Espanya
CATEGORIES:Esdeveniment PCB
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/05/open2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220609T103000
DTEND;TZID=Europe/Madrid:20220609T133000
DTSTAMP:20220523T080133Z
CREATED:20220523T075903Z
LAST-MODIFIED:20220523T080133Z
UID:74511-1654770600-1654781400@www.pcb.ub.edu
SUMMARY:Metabolomics-driven discoveries
DESCRIPTION:Can Metabolomics bring your research to the next level? Prof Oliver Fiehn will explain how to gain insight into metabolism and phenotype. \nInvited speaker: Prof. Oliver Fiehn\, PhD Director West Coast Metabolomics Center UC Davis Genome Center-Metabolomics (California). \nAbout Prof. Oliver Fiehn \nDirector West Coast Metabolomics Center UC Davis Genome Center – Metabolomics (California) \nProfessor Fiehn’s research aims to understand metabolism on a comprehensive level in human population cohorts\, animal and plant models\, and cells and microorganisms. He was recognized by Web of Science as a Highly Cited Researcher for the past 8 years.
URL:https://www.pcb.ub.edu/esdeveniment/metabolomics-driven-discoveries/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/05/Sino.jpg
ORGANIZER;CN="Olobion":MAILTO:info@olobion.ai
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220610T120000
DTEND;TZID=Europe/Madrid:20220610T140000
DTSTAMP:20220520T084454Z
CREATED:20220520T084439Z
LAST-MODIFIED:20220520T084454Z
UID:74500-1654862400-1654869600@www.pcb.ub.edu
SUMMARY:Targeting KRAS: Light at the End of the Tunnel
DESCRIPTION:Speaker: Mariano Barbacid\, PhD – AXA-CNIO Professor of Molecular Oncology – Centro Nacional de Investigaciones Oncológicas (CNIO) – Spanish National Cancer Research Center – Madrid\, Spain. \nKRAS\, an oncogene responsible for one fourth of all human cancers\, was discovered four decades ago. Yet\, the first selective inhibitor was not approved until 2021. In spite of this long-awaited breakthrough\, current KRAS inhibitors only block one of the multiple oncogenic isoforms\, KRASG12C which is primarily present in lung adenocarcinomas. Moreover\, tumor resistance to KRAS inhibitors appears to be a significant issue in the clinic (Awad et al.\, N Engl J Med\, 2021; Zhao et al.\, Nature 2021). In an effort to provide experimental information that might help to improve current KRAS targeting strategies\, we have generated two genetically engineered mouse models of Kras/Trp53-driven lung adenocarcinoma to (i) interrogate the mechanisms of drug resistance that appear in KRASG12C driven tumors and (ii) compare the therapeutic consequences of eliminating instead of inhibiting KRAS oncoproteins. Our results indicate that Kras gene amplification along with activation of drug metabolic pathways are major components of the mechanisms responsible for the acquisition of resistance. More importantly\, genetic evidence strongly supports the concept that Kras ablation provides superior therapeutic benefits than Kras inhibition\, thus arguing for the development of Kras degron strategies.
URL:https://www.pcb.ub.edu/esdeveniment/targeting-kras-light-at-the-end-of-the-tunnel/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/05/irb-2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220613T120000
DTEND;TZID=Europe/Madrid:20220613T143000
DTSTAMP:20220630T154541Z
CREATED:20220530T074758Z
LAST-MODIFIED:20220630T154541Z
UID:74684-1655121600-1655130600@www.pcb.ub.edu
SUMMARY:Single-cell biology of barrier tissues
DESCRIPTION:Speaker: Jose Ordovas-Montanes\, PhD – GL – Research Faculty – Division of Gastroenterology – Boston Children’s Hospital – Assistant Professor of Pediatrics – Harvard Medical School – Robertson Investigator – New York Stem Cell Foundation – Principal Faculty – Harvard Stem Cell Institute. \nFor a barrier tissue to effectively learn from previous immunological experiences\, it can sense\, adapt\, and store this information in essential or resident cell types. The foundational architecture of barriers includes essential stromal and stem-cell derived epithelial cell subsets that collectively perform key tissue functions. These cell subsets are critical for responding to\, and learning from\, environmental challenges\, together with the support of resident immune cells. However\, the ability of barrier tissues such as the skin\, gut or airway to efficiently adapt can become dysregulated during acute infection with viruses (SARS-CoV-2) or chronic disease states (inflammatory bowel disease). Identifying the essential cell types\, states and circuits of communication which predict and sustain disease in humans is vital to effectively treating these conditions. Our work across barrier tissues suggests that deriving insights from single-cell measurements can identify predictive determinants of organismal health and disease.
URL:https://www.pcb.ub.edu/esdeveniment/single-cell-biology-of-barrier-tissues/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
CATEGORIES:Esdeveniment PCB
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/05/2-6.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220615T090000
DTEND;TZID=Europe/Madrid:20220615T103000
DTSTAMP:20220630T154554Z
CREATED:20220614T150317Z
LAST-MODIFIED:20220630T154554Z
UID:73388-1655283600-1655289000@www.pcb.ub.edu
SUMMARY:Seminario: Uso del LinkedIn para científicos y emprendedores
DESCRIPTION:El Parc Científic de Barcelona organiza conjuntamente con Talento Científico un seminario sobre el uso profesional de LinkedIn como herramienta de networking y branding. El seminario va dirigido a científicos\, emprendedores\, empresarios y community managers que quieran profundizar sobre el uso de LinkedIn tanto como herramienta de networking para el uso de un perfil profesional\, como de branding corporativo para la página de su empresa.
URL:https://www.pcb.ub.edu/esdeveniment/seminario-uso-del-linkedin-para-cientificos-y-emprendedores/
LOCATION:Edifici Cluster II\, Sala Dolors Aleu\, Avinguda Dr. Marañón 6-8\, Barcelona\, Barcelona\, 08028
CATEGORIES:Esdeveniment PCB
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/04/Sin-titulo.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220615T120000
DTEND;TZID=Europe/Madrid:20220615T140000
DTSTAMP:20220608T081718Z
CREATED:20220608T081707Z
LAST-MODIFIED:20220608T081718Z
UID:75023-1655294400-1655301600@www.pcb.ub.edu
SUMMARY:Finding the needle in the haystack – target identification of anti-cancer small molecules
DESCRIPTION:Speaker: Dr. Juan Manuel Povedano Selfa \nPostdoctoral Researcher \nMcFadden’s Laboratory\, Department of Biochemistry\, UT Southwestern Medical Center\, Texas\, USA. \nIdentification of the mechanism of action of small molecules is one of the main roadblocks in drug development. In the last years\, I have developed genetic and chemoproteomic tools to unequivocally identify the target of small molecules with anti-cancer activity. These tools have led to the discovery of the target of a small molecule currently in clinical trials for the treatment of Ewing sarcoma.
URL:https://www.pcb.ub.edu/esdeveniment/finding-the-needle-in-the-haystack-target-identification-of-anti-cancer-small-molecules/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/06/irb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220616T090000
DTEND;TZID=Europe/Madrid:20220616T110000
DTSTAMP:20220526T090622Z
CREATED:20220526T090611Z
LAST-MODIFIED:20220526T090622Z
UID:74652-1655370000-1655377200@www.pcb.ub.edu
SUMMARY:PCBakers organitza el 16 de juny una segona venda de pastissos per col·laborar amb la Fundació Enllaç
DESCRIPTION:PCBakers ja preparen la seva segona venda de pastissos per recaptar fons el proper 16 de juny\, de 9 a 11h i en una nova ubicació\, l’entrada a torres pel carrer Baldiri Reixach. En aquest cas\, els diners recaptats es destinaran a la Fundació Enllaç\, que treballa per donar suport a les persones LGTBI+\, sobretot d’edat avançada i dependents\, treballant per garantir que els serveis socials els donen cabuda i oferint assessorament legal.
URL:https://www.pcb.ub.edu/esdeveniment/pcbakers-organitza-el-16-de-juny-una-segona-venda-de-pastissos-per-collaborar-amb-la-fundacio-enllac/
LOCATION:Parc Científic de Barcelona\, Carrer Baldiri Reixac\, 10\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/05/2022_June_PCBakers_horizontal-002.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220616T090000
DTEND;TZID=Europe/Madrid:20220616T153000
DTSTAMP:20220530T092517Z
CREATED:20220530T092459Z
LAST-MODIFIED:20220530T092517Z
UID:74711-1655370000-1655393400@www.pcb.ub.edu
SUMMARY:Análisis Térmico y Caracterización Reológica de Productos Farmacéuticos\, Cosméticos a Alimentarios
DESCRIPTION:NETZSCH les invita a asistir a una nueva jornada científico-técnica el próximo Jueves 16 de Junio en la Facultad de Farmacia de la Universidad de Barcelona\, y en la que se tratará la importancia del Análisis Térmico y la Caracterización Reológica de muestras de naturaleza farmacéutica\, cosmética y alimentaria. \n\nDurante la jornada se realizarán demostraciones de los equipos DSC 214 Polyma\, y reómetro Kinexus\, también del software.\nLes invitamos a traer sus propias muestras de interés\, y se las analizaremos posteriormente mediante cualquiera de las tecnologías a nuestra disposición para enviarle los resultados y conclusiones obtenidos.
URL:https://www.pcb.ub.edu/esdeveniment/analisis-termico-y-caracterizacion-reologica-de-productos-farmaceuticos-cosmeticos-a-alimentarios/
LOCATION:Edifici Cluster II\, Sala Dolors Aleu\, Avinguda Dr. Marañón 6-8\, Barcelona\, Barcelona\, 08028
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/05/123.jpg
ORGANIZER;CN="NETZSCH-Ger%C3%A4tebau GmbH":MAILTO:ramon.arauz@NETZSCH.com
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220617T120000
DTEND;TZID=Europe/Madrid:20220617T140000
DTSTAMP:20220506T105136Z
CREATED:20210506T105119Z
LAST-MODIFIED:20220506T105136Z
UID:74058-1655467200-1655474400@www.pcb.ub.edu
SUMMARY:Deep mutational scanning of entire human protein interaction domain families
DESCRIPTION:Protein interaction networks represent the backbone of the cell’s functional organization. Their architecture relies on the specificity of these interactions. Mutations that alter specificity may rewire the network and the way it corrdinates biological processes\, and lead to diseases or functional innovations. Understanding how the sequence of a protein determines the specificity of its interaction profile thus represents an important step towards a model of the genotype-phenotype map. To adress the sequence-function relationship`in protein-protein interactions\, we conducted a deep mutational scanning of the entire human basic leucine zipper (bZIP) interaction network. This interaction domain family\, composed of 54 members in humans\, has served as a model system for the study of protein interaction specificity. While the general rules of bZIP specificity are relatively well known\, it remains impossible to predict interaction partners accurately. Using our established deepPCA system\, we measured the effect of all single amino acid substitutions in all 54 members\, on the interaction with all 54 wild-type members. This dataset of ~2M quantitative protein-protein interaction measurements will enable training a deep neural network that captures the sequence-function relationship in order to quantitatively predict interaction between bZIPs from sequence alone. I will present the dataset and the deep learning model\, as well as preliminary data on two other families\, basic helix-loop-helix and SH3 domains\, for which we plan to collect 6 and 20M data points\, respectively. We foresee that applying this strategy on a variety of domain families of different architecture will enable the development of general models that can predict the affinity of an interaction from the sequenece of the two partners.
URL:https://www.pcb.ub.edu/esdeveniment/deep-mutational-scanning-of-entire-human-protein-interaction-domain-families/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/05/2-3.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220621T093000
DTEND;TZID=Europe/Madrid:20220621T110000
DTSTAMP:20220616T134400Z
CREATED:20220616T134306Z
LAST-MODIFIED:20220616T134400Z
UID:73931-1655803800-1655809200@www.pcb.ub.edu
SUMMARY:Formatos innovadores en divulgación científica
DESCRIPTION:El Parc Científic de Barcelona organiza un seminario sobre formatos innovadores en divulgación científica\, con el objetivo de mejorar las competencias comunicativas del personal investigador. La formación estará impartida por Estibaliz Urarte\, comunicadora científica\, y se enmarca dentro de las actividades del programa “Recerca en Societat” que tiene por objetivo fomentar vocaciones científicas y mejorar la difusión de la ciencia. \nEstibaliz Urarte es bióloga de formación y ha estado 8 años vinculada al mundo de la investigación en el área de la Fisiología y Bioquímica Vegetal. Posteriormente orientó su carrera hacia el ámbito de la comunicación científica y la divulgación. Se formó en el área de la SciComm cursando el posgrado en Comunicación Científica de la UVic y en la actualidad trabaja en dicho ámbito en el Área de Participación del Paciente en la Investigación de la Fundació de Recerca Sant Joan de Déu. Paralelamente\, escribe sobre ciencia para una revista cultural de carácter local y realiza colaboraciones puntuales con blogs y revistas de ciencia\, como Mujeres con Ciencia y Principia Magazine. También es secretaria general de la Asociación Catalana de Comunicación Científica y coordinadora del Grupo de Perspectiva de Género de dicha asociación. Desde 2021 es profesora de Divulgación Científica y Difusión de la I+D+i en la UIC dentro del grado de Ciencias Biomédicas.
URL:https://www.pcb.ub.edu/esdeveniment/formatos-innovadores-en-divulgacion-cientifica/
LOCATION:Edifici Cluster II\, Sala Dolors Aleu\, Avinguda Dr. Marañón 6-8\, Barcelona\, Barcelona\, 08028
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/05/Sin-titulo.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220622T093000
DTEND;TZID=Europe/Madrid:20220622T143000
DTSTAMP:20220616T134318Z
CREATED:20220616T134239Z
LAST-MODIFIED:20220616T134318Z
UID:74697-1655890200-1655908200@www.pcb.ub.edu
SUMMARY:Hair Care Summit
DESCRIPTION:Jornada científica y técnica sobre cosmética capilar \nJornada organizada conjuntamente con el Beauty Cluster.\n\nLos avances en cosmética capilar\, convergen y están cada vez más ligados con los avances en investigación en cabello y otras disciplinas como la química\, la biología\, la dermatología o la física. Comprender la evolución genética\, las propiedades y las características estructurales del cabello\, permiten también el desarrollo de nuevas soluciones en el campo del cuidado capilar.\n\nEn este marco de unión entre investigación e industria cosmética\, esta jornada científica y técnica tiene el objetivo de dar a conocer investigaciones recientes sobre biología capilar\, estudios o innovaciones actuales de la industria y entender las nuevas perspectivas del mercado y tendencias actuales.
URL:https://www.pcb.ub.edu/esdeveniment/hair-care-summit/
LOCATION:Edifici Cluster II\, Sala Dolors Aleu\, Avinguda Dr. Marañón 6-8\, Barcelona\, Barcelona\, 08028
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/05/cair.jpg
ORGANIZER;CN="SEQC":MAILTO:info@e-seqc.org
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220627T120000
DTEND;TZID=Europe/Madrid:20220627T140000
DTSTAMP:20220311T101715Z
CREATED:20220311T100847Z
LAST-MODIFIED:20220311T101715Z
UID:71833-1656331200-1656338400@www.pcb.ub.edu
SUMMARY:Tribute to Dr. Joan J. Guinovart\, Emeritus Professor at IRB Barcelona
DESCRIPTION:Dr. Joan J. Guinovart\, served as director of IRB Barcelona from its foundation in 2005 until 2018. Until 2021 he also led a highly productive laboratory on Metabolic Engineering and Diabetes Therapy\, making remarkable discoveries in carbohydrate metabolism\, diabetes and Lafora Disease. \nAn outstanding scientist\, an unparalleled leader and an amazing person\, he is\, at present\, an IRB Barcelona Emeritus Professor\, guiding\, advising and representing the Institute in a variety of events.
URL:https://www.pcb.ub.edu/esdeveniment/tribute-to-dr-joan-j-guinovart-emeritus-professor-at-irb-barcelona-2/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/03/guinovart_guinovart06.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220628T120000
DTEND;TZID=Europe/Madrid:20220628T140000
DTSTAMP:20220608T081858Z
CREATED:20220608T081845Z
LAST-MODIFIED:20220608T081858Z
UID:75032-1656417600-1656424800@www.pcb.ub.edu
SUMMARY:Proteostasis of Aging and Stem Cells
DESCRIPTION:Speaker: David Vilchez\, PhD – Professor\, CECAD Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases\, Medical Faculty\, University of Cologne\, Germany. \n«While it has long been noted that genome stability is a central function required for survival of stem cells\, the role of proteostasis has not been explored. With the asymmetric divisions invoked by stem cells\, the passage of damaged proteins to daughter cells can destroy the resulting lineage of cells and possibly accelerate the aging process. Furthermore\, the retention of damaged proteins by the stem cell could result in diminished stem cell function and premature aging. Therefore\, a firm understanding of how stem cells maintain their proteostasis is of central importance. Because experiments with mammalian embryonic stem cells have clearly demonstrated their capacity to replicate continuously in the absence of senescence\, we hypothesize that these cells could provide a novel paradigm to study the regulation of proteostasis and its demise in aging. We have recently described that human embryonic stem cells (hESCs) exhibit high proteasome activity compared to their differentiated counterparts. This enhanced proteasome activity is necessary for hESC function. Furthermore\, we have uncovered that PSMD11/rpn-6\, a key proteasomal subunit\, is required for this activity and its mode of regulation and conservation in the aging process of the invertebrate C. elegans. Our findings established RPN-6 as a potent regulator of proteasome activity that alleviates the deleterious effects associated with aberrant protein aggregation\, providing a powerful candidate to correct proteostatic deficiencies in disorders such as HD. Moreover\, our results in C. elegans led us to find that FOXO4\, a transcription factor associated with longevity\, regulates proteasome activity in hESCs and is necessary for hESCs differentiation into neural cells. Therefore\, our results established a novel regulation of proteostasis in hESCs that links longevity and stress resistance in invertebrates with hESC function and identity».
URL:https://www.pcb.ub.edu/esdeveniment/proteostasis-of-aging-and-stem-cells/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/06/irb-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220628T123000
DTEND;TZID=Europe/Madrid:20220628T140000
DTSTAMP:20220623T110002Z
CREATED:20220623T105923Z
LAST-MODIFIED:20220623T110002Z
UID:74997-1656419400-1656424800@www.pcb.ub.edu
SUMMARY:Successful CV and Job Channels in Spain for Ukrainian Refugees
DESCRIPTION:Barcelona Science Park together with INBRAIN Neuroelectronics organizes a seminar for all Ukrainian refugees based in Barcelona and surroundings to help them to adapt their CVs to Spanish standards and help them to find the right channels for job search. \nAgenda \n12:30 – 12:35 Welcome\, Anna Serra\, Director of Commercialization and Communication at Barcelona Science Park \n12:35 – 14:00 Writing successful CV and using right job search channels in Spain\, Carolina Aguilar\, CEO and co-founder of INBRAIN Neuroelectronics \nJob search can be challenging especially in a new country where the way people look for jobs and HR managers evaluate potential candidates can be different than in the country you come from. Therefore\, we organize this seminar to help Ukrainian refugees to get familiar with the way CV is prepared in Spain\, the core information to be included and omitted and different tips of how to look for jobs in the country. Knowing all the language difficulties\, the seminar is going to be translated in Ukrainian.
URL:https://www.pcb.ub.edu/esdeveniment/successful-cv-and-job-channels-in-spain-for-ukrainian-refugees/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/06/inbra.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220628T150000
DTEND;TZID=Europe/Madrid:20220628T170000
DTSTAMP:20220623T110055Z
CREATED:20220623T105835Z
LAST-MODIFIED:20220623T110055Z
UID:75535-1656428400-1656435600@www.pcb.ub.edu
SUMMARY:IBMB Seminars: Temporal Crontol of Neurogenesis
DESCRIPTION:Speaker: Bassem Hassan\, PhD. \nScientific Director and Deputy General Director at the\nInstitut du Cerveau – Paris Brain Institute (PBI). \nAn important manifestation of time during neurogenesis is the generation of different types of neurons from the same pool of progenitors over time. This means that neural progenitors can decode time and convert it into discrete quanta of different neuronal fates. However\, for progenitors to decode time into discrete quanta\, it must be true that total time is somehow genetically encoded. The extension and retraction of this total neurogenic time in closely related species is associated with changes in brain size\, often without significant changes to neuronal fate. However\, the genetic mechanisms that translate total time into neuronal numbers are not well understood. Previous work from the lab suggests that transcription factors known as proneural proteins are good candidates for this link: altering the timing of proneural protein expression or activity alters the size of the neuronal lineages they produce. Conversely\, changes the total time of neurogenesis alters proneural gene expression. These observations suggest an intimate mechanistic link between timing\, transcriptional regulation and brain size.
URL:https://www.pcb.ub.edu/esdeveniment/ibmb-seminars-temporal-crontol-of-neurogenesis/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/06/ibmb-2.jpg
ORGANIZER;CN="IBMB":MAILTO:contact@ibmb.csic.es
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220629T120000
DTEND;TZID=Europe/Madrid:20220629T140000
DTSTAMP:20220622T083453Z
CREATED:20220622T083413Z
LAST-MODIFIED:20220622T083453Z
UID:75338-1656504000-1656511200@www.pcb.ub.edu
SUMMARY:Shooting with electrons to unravel mechanistic insights of the human neutral amino acid transporter ASCT2 (SLC1A5)
DESCRIPTION:Speaker: Dr. Cristina Paulino \nAssociate Professor and Head of the cryo-Electron Microscopy Unit \nDepartment of Structural Biology and Membrane Enzymology – Groningen Biomolecular Sciences and Biotechnology Institute (GBB) \nUniversity of Groningen\, The Netherlands \nMy research aims at elucidating the mechanism of action of membrane transporters on a molecular level. To address these questions\, we use an interdisciplinary approach with cryo-EM as a central technique and contrast findings with comprehensive functional and computational studies. My talk will highlight how several advantages of cryo-EM can be exploited to study these pharmacological relevant transporters\, taking our studies on ASCT2 as an example. ASCT2 belongs to the SLC1A superfamily and is the main source of glutamine uptake in human cells. Its upregulation is strongly linked to cancer cell growth and poor patient survival\, making it a potential target in cancer therapy. We were able to solve the first structures of ASCT2\, and answer key mechanistic questions. Our observations are of great fundamental interest and pave the way for the rational design of inhibitors.
URL:https://www.pcb.ub.edu/esdeveniment/shooting-with-electrons-to-unravel-mechanistic-insights-of-the-human-neutral-amino-acid-transporter-asct2-slc1a5/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/06/iiiiirb-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220630T170000
DTEND;TZID=Europe/Madrid:20220630T190000
DTSTAMP:20220630T154723Z
CREATED:20220629T082223Z
LAST-MODIFIED:20220630T154723Z
UID:75329-1656608400-1656615600@www.pcb.ub.edu
SUMMARY:Unraveling the complexity of cellular senescence
DESCRIPTION:Speaker: Federico Pietrocola\, PhD – GL – Department of Biosciences and Nutrition – Karolinska Institutet – Sweden. \nThe role of senescent cells in aging and age-related pathologies is well established. Nonetheless\, senescent cells exhibit remarkable – functional and molecular – heterogeneity\, which limits the implementation of senescence-targeted therapies. In the lab\, we are specifically interested in resolving the complexity of the senescent phenotype\, aiming to shed light on the vulnerabilities that characterise pathologically meaningful senescent cells. Our current work focuses on identifying metabolic addictions of senescent cells\, with particular emphasis on the role of arginine metabolism in the establishment and maintenance of the senescent state.
URL:https://www.pcb.ub.edu/esdeveniment/unraveling-the-complexity-of-cellular-senescence/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
CATEGORIES:Esdeveniment PCB
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/06/Seminars4.jpg
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END:VCALENDAR