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X-WR-CALNAME:Parc Científic de Barcelona
X-ORIGINAL-URL:https://www.pcb.ub.edu
X-WR-CALDESC:Esdeveniments per Parc Científic de Barcelona
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220113T150000
DTEND;TZID=Europe/Madrid:20220113T170000
DTSTAMP:20211119T115451Z
CREATED:20211119T115048Z
LAST-MODIFIED:20211119T115451Z
UID:68468-1642086000-1642093200@www.pcb.ub.edu
SUMMARY:ENABLECARES - Entrepreneurship Course 2021
DESCRIPTION:Training future leaders in health and life Science. Integration of entrepreneurship skills \n\n\nEntrepreneurship & innovation training course optimized for biomedical researchers is aligned with market demands and strategic policies. This course seek to empower junior scientists by giving them the tools to explore their potential as entrepreneurs and their interest in pursuing careers in business or innovation management\, thereby increasing their employability in academia or beyond. \nAfter the completion of the course participants will become familiar with the process of defining a business plan and confer the skills needed to apply strategy\, marketing\, finance\, and innovation concepts to support critical strategic decisions regarding the start of a new business. \nThe ENABLECARES entrepreneurship course will allow participants to: \n\nAcquire insights regarding strategy\, marketing\, finance and innovation concepts relating to the creation of a new business in high-technology markets.\nLearn to apply these concepts to analyse the challenges encountered by entrepreneurs when starting a business in a high-technology / high-service context.\nLearn to substantiate the critical decisions underlying the development of a feasible business plan.\n\nWHERE \nFelix Serratosa Room (subject to COVID measures) \nAGENDA \nSession 1: Thursday\,  9 December 2021\, 15:00 to 17:00\nSession 2: Thursday\, 16 December 2021\, 15:00 to 17:00\nSession 3: Thursday\, 13 January 2022\, 15:00 to 17:00\nSession 4: Thursday\, 20 January 2022\, 15:00 to 17:00\nSession 5: Thursday\, 27 January 2022\, 15:00 to 17:30\nSession 6: Thursday\,  3 February 2022\, 15:00 to 17:00 \nREGISTRATION & CONFIRMATION \nThis course is free of charge and has limited places. Participants will be selected according to fulfilment of requirements\, motivation and prospect of using the lessons learned. A confirmation email will be sent after the registration deadline. \nTo register\, please click on the following link https://forms.gle/pjB2eD1LKcC1LxYv6 \nRegistration Deadline – December 1. \n\n\n\n\nENABLECARES – Entrepreneurship Programme 2021 \nDecember 9 2021 – February 3 2022 \nRegistration Deadline – Wednesday\, 1 December 2021 \nhttps://forms.gle/pjB2eD1LKcC1LxYv6
URL:https://www.pcb.ub.edu/esdeveniment/enablecares-entrepreneurship-course-2021-3/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2021/11/logo-irb-10.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220114T120000
DTEND;TZID=Europe/Madrid:20220114T140000
DTSTAMP:20220105T140559Z
CREATED:20220105T140422Z
LAST-MODIFIED:20220105T140559Z
UID:69833-1642161600-1642168800@www.pcb.ub.edu
SUMMARY:Ana Martin-Villalba\, PhD - Title TBD
DESCRIPTION:Speaker: Ana Martin-Villalba\, PhD. – Division of Molecular Neurobiology – German Cancer Research Center (DKFZ) – Heidelberg – Germany \n 
URL:https://www.pcb.ub.edu/esdeveniment/ana-martin-villalba-phd-title-tbd/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/png:https://www.pcb.ub.edu/wp-content/uploads/2022/01/biysc_irb_logo.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220114T120000
DTEND;TZID=Europe/Madrid:20220114T140000
DTSTAMP:20220110T075407Z
CREATED:20220110T075353Z
LAST-MODIFIED:20220110T075407Z
UID:69851-1642161600-1642168800@www.pcb.ub.edu
SUMMARY:Interferon signalling is required for activation of neural stem cells independent of its immune function
DESCRIPTION:Stem cells show intrinsic interferon signalling\, which protects them from viral infections. In the brain\, type I interferon signalling increases in neural stem cells (NSCs) as they age and reduces their ability to become activated for repair. How interferon regulates stem cell activity and if it is coupled to an immune function remains poorly understood. To address this\, we examined interferon receptor deficient mice and interferon-bexposed NSCs. At young ages\, the activation rate of NSCs is strongly reduced in mutant mice and not further influenced by age. NSCs exposed to interferon-b arrested in G0 of the cell cycle and transiently increased their TOR signalling before also switching off this central signalling pathway to respond to external stimuli. Importantly\, this regulation of TOR is needed to repress translation of key stem cell activity factors like Sox2. Single cell transcriptomes of the stem cell niche reveal that the increase of interferon signalling with age involves interferon receptors.While this is shared by endothelial cells and mature neurons\, differentiating progeny remain unaffected by age. Our results show that interferons are key regulators of adult stem cell dynamics\, beneficial in the young and harmful in the old brain.
URL:https://www.pcb.ub.edu/esdeveniment/interferon-signalling-is-required-for-activation-of-neural-stem-cells-independent-of-its-immune-function/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/01/cientificos-del-irb-barcelona-bailan-delante-L-AAbgC_.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220120T150000
DTEND;TZID=Europe/Madrid:20220120T170000
DTSTAMP:20211119T115509Z
CREATED:20211119T115120Z
LAST-MODIFIED:20211119T115509Z
UID:68474-1642690800-1642698000@www.pcb.ub.edu
SUMMARY:ENABLECARES - Entrepreneurship Course 2021
DESCRIPTION:Training future leaders in health and life Science. Integration of entrepreneurship skills \n\n\nEntrepreneurship & innovation training course optimized for biomedical researchers is aligned with market demands and strategic policies. This course seek to empower junior scientists by giving them the tools to explore their potential as entrepreneurs and their interest in pursuing careers in business or innovation management\, thereby increasing their employability in academia or beyond. \nAfter the completion of the course participants will become familiar with the process of defining a business plan and confer the skills needed to apply strategy\, marketing\, finance\, and innovation concepts to support critical strategic decisions regarding the start of a new business. \nThe ENABLECARES entrepreneurship course will allow participants to: \n\nAcquire insights regarding strategy\, marketing\, finance and innovation concepts relating to the creation of a new business in high-technology markets.\nLearn to apply these concepts to analyse the challenges encountered by entrepreneurs when starting a business in a high-technology / high-service context.\nLearn to substantiate the critical decisions underlying the development of a feasible business plan.\n\nWHERE \nFelix Serratosa Room (subject to COVID measures) \nAGENDA \nSession 1: Thursday\,  9 December 2021\, 15:00 to 17:00\nSession 2: Thursday\, 16 December 2021\, 15:00 to 17:00\nSession 3: Thursday\, 13 January 2022\, 15:00 to 17:00\nSession 4: Thursday\, 20 January 2022\, 15:00 to 17:00\nSession 5: Thursday\, 27 January 2022\, 15:00 to 17:30\nSession 6: Thursday\,  3 February 2022\, 15:00 to 17:00 \nREGISTRATION & CONFIRMATION \nThis course is free of charge and has limited places. Participants will be selected according to fulfilment of requirements\, motivation and prospect of using the lessons learned. A confirmation email will be sent after the registration deadline. \nTo register\, please click on the following link https://forms.gle/pjB2eD1LKcC1LxYv6 \nRegistration Deadline – December 1. \n\n\n\n\nENABLECARES – Entrepreneurship Programme 2021 \nDecember 9 2021 – February 3 2022 \nRegistration Deadline – Wednesday\, 1 December 2021 \nhttps://forms.gle/pjB2eD1LKcC1LxYv6
URL:https://www.pcb.ub.edu/esdeveniment/enablecares-entrepreneurship-course-2021-4/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2021/11/logo-irb-10.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220121T150000
DTEND;TZID=Europe/Madrid:20220121T180000
DTSTAMP:20220112T082548Z
CREATED:20220112T082536Z
LAST-MODIFIED:20220112T082548Z
UID:69953-1642777200-1642788000@www.pcb.ub.edu
SUMMARY:Nuclear Receptors\, Circadian Rhythms\, and Metabolism
DESCRIPTION:Speaker: Mitchell A. Lazar\, PhD. – Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases – Director\, Institute for Diabetes\, Obesity and Metabolism – University of Pennsylvania – Perelman School of Medicine \n 
URL:https://www.pcb.ub.edu/esdeveniment/nuclear-receptors-circadian-rhythms-and-metabolism/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/01/irb-logo.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220126T120000
DTEND;TZID=Europe/Madrid:20220126T170000
DTSTAMP:20220121T091801Z
CREATED:20220121T091748Z
LAST-MODIFIED:20220121T091801Z
UID:70222-1643198400-1643216400@www.pcb.ub.edu
SUMMARY:Defining the mechanisms regulating glandular stem cell multipotency [IRB Research Nodes Seminar]
DESCRIPTION:Glandular epithelia including the mammary gland (MG) and the prostate glands are composed of basal cells (BCs) and luminal cells (LCs). Many glandular epithelia develop from multipotent basal stem cells (BSCs) that are replaced in adult life by distinct pools of unipotent stem cells. However\, adult unipotent BSCs can reactivate multipotency in regenerative conditions and upon oncogene expression. This suggests that an active mechanism restricts BSC multipotency during physiological conditions. We show that the ablation of LCs reactivates BSC multipotency from multiple epithelia both in vivo in mice and in vitro in organoids. Bulk and single-cell RNA sequencing revealed that\, after LC ablation\, BSCs activate a hybrid basal and luminal cell differentiation program before giving rise to LCs. By predicting ligand-receptor pairs from single-cell data\, we found that TNF\, which is secreted by LCs\, restricts BC multipotency under normal physiological conditions. By contrast\, the Notch\, Wnt and EGFR pathways were activated in BSCs and their progeny after LC ablation; blocking these pathways\, or stimulating TNF pathway\, inhibited regeneration-induced BC multipotency. Our study demonstrates that the communication between LCs and BCs is essential to maintain lineage fidelity in glandular epithelial stem cells. \nWe have described different conditions in which BSC are multipotent\, the comparison of the upregulated genes in BC in these conditions revealed an important role of the extracellular matrix (ECM) in the regulation of BSC multipotency. Using organoids\, we show that Col1 and ECM stiffness are key to promote the switch from unipotency to multipotency of BSCs. Using single-cell RNA sequencing analysis\, we are studying the contribution of Col1-signalling and ECM stiffness in the mechanisms leading to multipotency activation. The functional validation of these results will uncover the role of stroma-epithelia communication in BSC multipotency regulation and by which mechanisms the ECM stiffness and composition is controlling cell behaviour. Altogether\, this study will reveal the complex regulation of cell fate maintenance in glandular epithelia\, which can be lost in pathological conditions\, such as cancer.
URL:https://www.pcb.ub.edu/esdeveniment/defining-the-mechanisms-regulating-glandular-stem-cell-multipotency-irb-research-nodes-seminar/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/png:https://www.pcb.ub.edu/wp-content/uploads/2022/01/logo-irb.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220127T150000
DTEND;TZID=Europe/Madrid:20220127T170000
DTSTAMP:20211119T115525Z
CREATED:20211119T115208Z
LAST-MODIFIED:20211119T115525Z
UID:68480-1643295600-1643302800@www.pcb.ub.edu
SUMMARY:ENABLECARES - Entrepreneurship Course 2021
DESCRIPTION:Training future leaders in health and life Science. Integration of entrepreneurship skills \n\n\nEntrepreneurship & innovation training course optimized for biomedical researchers is aligned with market demands and strategic policies. This course seek to empower junior scientists by giving them the tools to explore their potential as entrepreneurs and their interest in pursuing careers in business or innovation management\, thereby increasing their employability in academia or beyond. \nAfter the completion of the course participants will become familiar with the process of defining a business plan and confer the skills needed to apply strategy\, marketing\, finance\, and innovation concepts to support critical strategic decisions regarding the start of a new business. \nThe ENABLECARES entrepreneurship course will allow participants to: \n\nAcquire insights regarding strategy\, marketing\, finance and innovation concepts relating to the creation of a new business in high-technology markets.\nLearn to apply these concepts to analyse the challenges encountered by entrepreneurs when starting a business in a high-technology / high-service context.\nLearn to substantiate the critical decisions underlying the development of a feasible business plan.\n\nWHERE \nFelix Serratosa Room (subject to COVID measures) \nAGENDA \nSession 1: Thursday\,  9 December 2021\, 15:00 to 17:00\nSession 2: Thursday\, 16 December 2021\, 15:00 to 17:00\nSession 3: Thursday\, 13 January 2022\, 15:00 to 17:00\nSession 4: Thursday\, 20 January 2022\, 15:00 to 17:00\nSession 5: Thursday\, 27 January 2022\, 15:00 to 17:30\nSession 6: Thursday\,  3 February 2022\, 15:00 to 17:00 \nREGISTRATION & CONFIRMATION \nThis course is free of charge and has limited places. Participants will be selected according to fulfilment of requirements\, motivation and prospect of using the lessons learned. A confirmation email will be sent after the registration deadline. \nTo register\, please click on the following link https://forms.gle/pjB2eD1LKcC1LxYv6 \nRegistration Deadline – December 1. \n\n\n\n\nENABLECARES – Entrepreneurship Programme 2021 \nDecember 9 2021 – February 3 2022 \nRegistration Deadline – Wednesday\, 1 December 2021 \nhttps://forms.gle/pjB2eD1LKcC1LxYv6
URL:https://www.pcb.ub.edu/esdeveniment/enablecares-entrepreneurship-course-2021-5/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2021/11/logo-irb-10.jpg
END:VEVENT
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