BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Parc Científic de Barcelona - ECPv6.18.0//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Parc Científic de Barcelona
X-ORIGINAL-URL:https://www.pcb.ub.edu
X-WR-CALDESC:Esdeveniments per Parc Científic de Barcelona
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240719T120000
DTEND;TZID=Europe/Madrid:20240719T133000
DTSTAMP:20240625T094625Z
CREATED:20240625T094625Z
LAST-MODIFIED:20240625T094625Z
UID:96706-1721390400-1721395800@www.pcb.ub.edu
SUMMARY:Chemical control of cell plasticity in cancer and inflammation
DESCRIPTION:Speaker:  Raphaël Rodriguez\, PhD\, FRSC.  Skłodowska-Curie Chair of Chemical Biology. Institut Curie Paris. France. \nAbstract:\n\nCells can rapidly and reversibly adopt distinct states and this can occur independently of genetic alterations\, a biological mechanism commonly referred to as ‘cell plasticity’. CD44 is a plasma membrane glycoprotein associated with development\, immune cell activation as well as tumorigenesis. Although often described as a cell-surface marker\, the biological function of CD44 remains elusive. We discovered that CD44 mediates the uptake of metals including copper and iron bound to hyaluronates in cells from distinct tissues. This glycan-mediated metal endocytosis mechanism is enhanced during immune cell activation and in cancer cells undergoing epithelial–mesenchymal transition. We found that copper(II) catalyzes a previously uncharted chemical reaction in mitochondria required for the production of key metabolites. In contrast\, iron is required in the nucleus to promote the activity of specific demethylases. Together\, these metals orchestrate metabolic and epigenetic programming of cell plasticity\, establishing CD44 as a regulator of cell state transition. We developed new classes of small molecules that selectively interfere with these metal-catalyzed chemical processes in cells. Supformin specifically targets mitochondrial copper(II)\, thereby antagonizing macrophage activation in several pre-clinical models of acute inflammation and cancer. This validates a key concept in biology whereby pharmacological control of cell plasticity confers therapeutic benefits. This also suggest a competition for metal uptake by immune and cancer cells that may enable tumor progression. Structurally distinct classes of small molecule were developed to manipulate lysosomal iron providing control of cell fate with induction of or protection against ferroptosis . These findings illuminate a universal metal uptake mechanism and the critical role of metals as master regulators of cell plasticity\, paving the way towards the development of next generation therapeutics.
URL:https://www.pcb.ub.edu/esdeveniment/chemical-control-of-cell-plasticity-in-cancer-and-inflammation/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2024/06/irb-6.jpg
END:VEVENT
END:VCALENDAR