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DTSTART;TZID=Europe/Madrid:20221028T120000
DTEND;TZID=Europe/Madrid:20221028T140000
DTSTAMP:20221024T105024Z
CREATED:20221024T105013Z
LAST-MODIFIED:20221024T105024Z
UID:78387-1666958400-1666965600@www.pcb.ub.edu
SUMMARY:The roles of mobile DNA in human cancer
DESCRIPTION:Speaker: Jose Tubio\, Ph.D. Group Leader\, Mobile Genomes lab\, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS)\, University of Santiago de Compostela\, Spain. \nSomatic retrotransposition represents the most frequent class of structural variation in some human cancers. For the last 10 years\, we have illuminated two relevant mutational mechanisms by which somatic RT can provide the mutations that a cancer clone requires to survive and grow (PMID: 25082706; PMID: 32024998). Currently\, our research focuses on the use of long-read sequencing and chromatin conformation capture techniques for the discovery of novel\, previously unreported mutational roles of somatic retrotransposition in human cancer. \nJose Tubio has carried out his research at the forefront of cancer genomics\, being involved in the discovery of new cancer genes in hematological cancers and bone cancers\, the identification of new mechanisms of mutation\, the characterization of mechanisms that drive the dynamics of metastasis\, the identification of genes that drive transmissible cancers\, and the identification of early genetic mutations that occur in normal tissues and their role in tumour transformation.
URL:https://www.pcb.ub.edu/esdeveniment/the-roles-of-mobile-dna-in-human-cancer/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
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