BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Parc Científic de Barcelona - ECPv6.18.0//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Parc Científic de Barcelona
X-ORIGINAL-URL:https://www.pcb.ub.edu
X-WR-CALDESC:Esdeveniments per Parc Científic de Barcelona
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220628T120000
DTEND;TZID=Europe/Madrid:20220628T140000
DTSTAMP:20220608T081858Z
CREATED:20220608T081845Z
LAST-MODIFIED:20220608T081858Z
UID:75032-1656417600-1656424800@www.pcb.ub.edu
SUMMARY:Proteostasis of Aging and Stem Cells
DESCRIPTION:Speaker: David Vilchez\, PhD – Professor\, CECAD Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases\, Medical Faculty\, University of Cologne\, Germany. \n«While it has long been noted that genome stability is a central function required for survival of stem cells\, the role of proteostasis has not been explored. With the asymmetric divisions invoked by stem cells\, the passage of damaged proteins to daughter cells can destroy the resulting lineage of cells and possibly accelerate the aging process. Furthermore\, the retention of damaged proteins by the stem cell could result in diminished stem cell function and premature aging. Therefore\, a firm understanding of how stem cells maintain their proteostasis is of central importance. Because experiments with mammalian embryonic stem cells have clearly demonstrated their capacity to replicate continuously in the absence of senescence\, we hypothesize that these cells could provide a novel paradigm to study the regulation of proteostasis and its demise in aging. We have recently described that human embryonic stem cells (hESCs) exhibit high proteasome activity compared to their differentiated counterparts. This enhanced proteasome activity is necessary for hESC function. Furthermore\, we have uncovered that PSMD11/rpn-6\, a key proteasomal subunit\, is required for this activity and its mode of regulation and conservation in the aging process of the invertebrate C. elegans. Our findings established RPN-6 as a potent regulator of proteasome activity that alleviates the deleterious effects associated with aberrant protein aggregation\, providing a powerful candidate to correct proteostatic deficiencies in disorders such as HD. Moreover\, our results in C. elegans led us to find that FOXO4\, a transcription factor associated with longevity\, regulates proteasome activity in hESCs and is necessary for hESCs differentiation into neural cells. Therefore\, our results established a novel regulation of proteostasis in hESCs that links longevity and stress resistance in invertebrates with hESC function and identity».
URL:https://www.pcb.ub.edu/esdeveniment/proteostasis-of-aging-and-stem-cells/
LOCATION:Edifici Torres R+D+I\, Auditori Antoni Caparrós\, C/ Baldiri Reixac 4-8\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/06/irb-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220628T123000
DTEND;TZID=Europe/Madrid:20220628T140000
DTSTAMP:20220623T110002Z
CREATED:20220623T105923Z
LAST-MODIFIED:20220623T110002Z
UID:74997-1656419400-1656424800@www.pcb.ub.edu
SUMMARY:Successful CV and Job Channels in Spain for Ukrainian Refugees
DESCRIPTION:Barcelona Science Park together with INBRAIN Neuroelectronics organizes a seminar for all Ukrainian refugees based in Barcelona and surroundings to help them to adapt their CVs to Spanish standards and help them to find the right channels for job search. \nAgenda \n12:30 – 12:35 Welcome\, Anna Serra\, Director of Commercialization and Communication at Barcelona Science Park \n12:35 – 14:00 Writing successful CV and using right job search channels in Spain\, Carolina Aguilar\, CEO and co-founder of INBRAIN Neuroelectronics \nJob search can be challenging especially in a new country where the way people look for jobs and HR managers evaluate potential candidates can be different than in the country you come from. Therefore\, we organize this seminar to help Ukrainian refugees to get familiar with the way CV is prepared in Spain\, the core information to be included and omitted and different tips of how to look for jobs in the country. Knowing all the language difficulties\, the seminar is going to be translated in Ukrainian.
URL:https://www.pcb.ub.edu/esdeveniment/successful-cv-and-job-channels-in-spain-for-ukrainian-refugees/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/06/inbra.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220628T150000
DTEND;TZID=Europe/Madrid:20220628T170000
DTSTAMP:20220623T110055Z
CREATED:20220623T105835Z
LAST-MODIFIED:20220623T110055Z
UID:75535-1656428400-1656435600@www.pcb.ub.edu
SUMMARY:IBMB Seminars: Temporal Crontol of Neurogenesis
DESCRIPTION:Speaker: Bassem Hassan\, PhD. \nScientific Director and Deputy General Director at the\nInstitut du Cerveau – Paris Brain Institute (PBI). \nAn important manifestation of time during neurogenesis is the generation of different types of neurons from the same pool of progenitors over time. This means that neural progenitors can decode time and convert it into discrete quanta of different neuronal fates. However\, for progenitors to decode time into discrete quanta\, it must be true that total time is somehow genetically encoded. The extension and retraction of this total neurogenic time in closely related species is associated with changes in brain size\, often without significant changes to neuronal fate. However\, the genetic mechanisms that translate total time into neuronal numbers are not well understood. Previous work from the lab suggests that transcription factors known as proneural proteins are good candidates for this link: altering the timing of proneural protein expression or activity alters the size of the neuronal lineages they produce. Conversely\, changes the total time of neurogenesis alters proneural gene expression. These observations suggest an intimate mechanistic link between timing\, transcriptional regulation and brain size.
URL:https://www.pcb.ub.edu/esdeveniment/ibmb-seminars-temporal-crontol-of-neurogenesis/
LOCATION:Edifici Cluster I\, Aula Fèlix Serratosa\, C/ Baldiri Reixac 10-12\, Barcelona\, Barcelona\, 08028\, Espanya
ATTACH;FMTTYPE=image/jpeg:https://www.pcb.ub.edu/wp-content/uploads/2022/06/ibmb-2.jpg
ORGANIZER;CN="IBMB":MAILTO:contact@ibmb.csic.es
END:VEVENT
END:VCALENDAR