{"id":101966,"date":"2025-02-07T12:01:19","date_gmt":"2025-02-07T11:01:19","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/?post_type=tribe_events&#038;p=101966"},"modified":"2025-02-07T12:04:04","modified_gmt":"2025-02-07T11:04:04","slug":"the-regulation-of-the-regulator-of-the-regulator-of-the-regulator-of-sexual-conversion-in-plasmodium-falciparum","status":"publish","type":"tribe_events","link":"https:\/\/www.pcb.ub.edu\/es\/esdeveniment\/the-regulation-of-the-regulator-of-the-regulator-of-the-regulator-of-sexual-conversion-in-plasmodium-falciparum\/","title":{"rendered":"The regulation of the regulator of the regulator of the regulator of sexual conversion in Plasmodium falciparum"},"content":{"rendered":"<p><strong>Speaker: Dr. Alfred Cort\u00e9s<\/strong><\/p>\n<p><strong>ICREA Research Professor, Malaria Epigenetics Lab, ISGlobal, Barcelona, Spain.<\/strong><\/p>\n<p>The protozoan parasite\u00a0<em>Plasmodium falciparum<\/em>\u00a0produces the majority of malaria cases and deaths. At each round of asexual replication in the human blood, some parasites convert into sexual precursors, called gametocytes, that are essential for human-to-vector transmission. The sexual conversion rate determines the relative parasite investment between infection in the same host and transmission. Sexual conversion is orchestrated by the master regulator PfAP2-G, a transcription factor of the ApiAP2 family. However, how the expression of PfAP2-G is regulated and activated in response to specific conditions of the blood environment remains poorly understood. I will present new insight into the complex regulatory mechanism of sexual conversion, which involves another transcription factor, a chromatin modifier, a non-coding antisense RNA, epigenetic changes in heterochromatin at a specific locus, and positive and negative feedback loops.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Speaker: Dr. Alfred Cort\u00e9s ICREA Research Professor, Malaria Epigenetics Lab, ISGlobal, Barcelona, Spain. The protozoan parasite\u00a0Plasmodium falciparum\u00a0produces the majority of malaria cases and deaths. At each round of asexual replication&#8230;<\/p>\n","protected":false},"author":8,"featured_media":101967,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[],"class_list":["post-101966","tribe_events","type-tribe_events","status-publish","has-post-thumbnail"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The regulation of the regulator of the regulator of the regulator of sexual conversion in Plasmodium falciparum - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/esdeveniment\/the-regulation-of-the-regulator-of-the-regulator-of-the-regulator-of-sexual-conversion-in-plasmodium-falciparum\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The regulation of the regulator of the regulator of the regulator of sexual conversion in Plasmodium falciparum - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Speaker: Dr. Alfred Cort\u00e9s ICREA Research Professor, Malaria Epigenetics Lab, ISGlobal, Barcelona, Spain. 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