{"id":88007,"date":"2023-09-18T12:22:05","date_gmt":"2023-09-18T10:22:05","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/javier-ramon-azcon-recibe-una-beca-erc-proof-of-concept\/"},"modified":"2025-10-13T15:03:33","modified_gmt":"2025-10-13T13:03:33","slug":"javier-ramon-azcon-recibe-una-beca-erc-proof-of-concept","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/es\/javier-ramon-azcon-recibe-una-beca-erc-proof-of-concept\/","title":{"rendered":"Javier Ram\u00f3n Azc\u00f3n recibe una beca ERC Proof of Concept"},"content":{"rendered":"

Javier Ram\u00f3n Azc\u00f3n, profesor de investigaci\u00f3n ICREA y l\u00edder del grupo de Biosensores para Bioingenier\u00eda del IBEC<\/a>, con sede en el Parque Cient\u00edfico de Barcelona, ha sido galardonado con una beca ERC Proof of Concept (PoC)<\/a>, una prestigiosa financiaci\u00f3n que concede el Consejo Europeo de Investigaci\u00f3n para explorar el potencial comercial y social de la investigaci\u00f3n llevada a cabo en instituciones europeas. El proyecto de Ramon, Uniink, se enfoca en el tratamiento de la diabetes tipo 1 con terapia celular y bioimpresi\u00f3n 3D.<\/strong><\/p>\n

La diabetes tipo 1 es una afecci\u00f3n en la que el propio sistema inmune destruye las c\u00e9lulas \u03b2 del p\u00e1ncreas, encargadas de producir insulina, una hormona que interviene en el control de la glucosa en sangre.<\/p>\n

Una alternativa a las famosas inyecciones de insulina, que no permiten una respuesta tan din\u00e1mica a los cambios de glucosa, es la terapia celular. Concretamente, el trasplante de islotes pancre\u00e1ticos de donantes fallecidos.\u00a0 Los islotes son grupos de c\u00e9lulas del p\u00e1ncreas que contienen, entre otras, c\u00e9lulas \u03b2 productoras de insulina. A pesar de ser un tratamiento efectivo con m\u00faltiples beneficios, no es posible aplicarlo de forma generalizada debido a la dificultad de encontrar donantes compatibles y a la necesidad de inmunosuprimir a la persona receptora. Esto \u00faltimo es necesario porque el sistema inmune del hu\u00e9sped reconoce los islotes trasplantados como extra\u00f1os y los ataca.<\/p>\n

\"\"

Representaci\u00f3n esquem\u00e1tica de las microesferas biocompatibles del proyecto Uniink (Imagen: IBEC).<\/p><\/div>\n

Uniink se presenta como una evoluci\u00f3n a este tipo de terapia. El proyecto propone un novedoso procedimiento de bioimpresi\u00f3n 3D para fabricar grandes cantidades de microesferas biocompatibles cargadas de c\u00e9lulas que son capaces de secretar insulina en respuesta a est\u00edmulos de glucosa extracelular. La creaci\u00f3n de barreras f\u00edsicas, como la encapsulaci\u00f3n, puede proteger a las c\u00e9lulas trasplantadas del sistema inmunitario del hu\u00e9sped. Esto permitir\u00eda la recuperaci\u00f3n del injerto, restaurando la regulaci\u00f3n fisiol\u00f3gica de la glucosa.<\/p>\n

Este innovador sistema fue desarrollado por Laura Clua Ferr\u00e9<\/strong> durante su tesis doctoral en el grupo de Ram\u00f3n. Para el nuevo proyecto, que recoge el testigo de Clua, el equipo del IBEC probar\u00e1 la eficacia de Uniink en modelos de rat\u00f3n y colaborar\u00e1 con el grupo de Anna Novials<\/strong> del Instituto de investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) para obtener las c\u00e9lulas de donantes.<\/p>\n

Por el momento, ya se ha solicitado una patente para el sistema de encapsulaci\u00f3n y, tal y como explica Javier Ram\u00f3n:\u00a0\u201cA lo largo del proyecto, exploraremos la posibilidad de establecer una nueva empresa y colaboraciones con socios privados, con el objetivo de llevar esta tecnolog\u00eda hacia su aplicaci\u00f3n cl\u00ednica. En resumen, Uniink tiene el potencial de transformar el tratamiento de la diabetes tipo 1 de manera significativa, brindando nuevas esperanzas a los pacientes afectados por esta condici\u00f3n.\u201d<\/p>\n

\u00bb M\u00e1s informaci\u00f3n: <\/strong>web del IBEC <\/a>[<\/a>+<\/a><\/strong>]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Javier Ram\u00f3n Azc\u00f3n, profesor de investigaci\u00f3n ICREA y l\u00edder del grupo de Biosensores para Bioingenier\u00eda del IBEC, con sede en el Parque Cient\u00edfico de Barcelona, ha sido galardonado con una…<\/p>\n","protected":false},"author":14,"featured_media":88004,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[345],"tags":[],"class_list":["post-88007","post","type-post","status-publish","format-standard","has-post-thumbnail","category-financiacion"],"acf":[],"yoast_head":"\nJavier Ram\u00f3n Azc\u00f3n recibe una beca ERC Proof of Concept - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/es\/javier-ramon-azcon-recibe-una-beca-erc-proof-of-concept\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Javier Ram\u00f3n Azc\u00f3n recibe una beca ERC Proof of Concept - 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