{"id":39004,"date":"2020-04-22T00:00:00","date_gmt":"2020-04-21T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/\/las-histonas-y-sus-modificaciones-son-clave-para-la-adaptacion-al-estres-celular\/"},"modified":"2020-11-16T16:22:16","modified_gmt":"2020-11-16T15:22:16","slug":"las-histonas-y-sus-modificaciones-son-clave-para-la-adaptacion-al-estres-celular","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/es\/las-histonas-y-sus-modificaciones-son-clave-para-la-adaptacion-al-estres-celular\/","title":{"rendered":"Las histonas y sus modificaciones son clave para la adaptaci\u00f3n al estr\u00e9s celular"},"content":{"rendered":"<p>Las plantas, los animales y, dentro de ellos, las personas, tenemos el material gen\u00e9tico empaquetado dentro de la c\u00e9lula, y las prote\u00ednas responsables de garantizar esa estructura son las histonas. Adem\u00e1s, las histonas juegan un papel importante en regular qu\u00e9 genes se ponen en funcionamiento y cu\u00e1ndo lo hacen: un est\u00edmulo determinado modifica una histona y hace que esta permita o bloquee la expresi\u00f3n de un gen.<\/p>\n<p>El laboratorio de Se\u00f1alizaci\u00f3n Celular del IRB Barcelona, que lideran Eul\u00e0lia de Nadal y Francesc Posas, ha identificado m\u00e1s de 200 regiones (amino\u00e1cidos) en las histonas que, en condiciones de estr\u00e9s celular, sufren modificaciones para regular la respuesta a dicha situaci\u00f3n.<\/p>\n<p>Adem\u00e1s, han observado que el estr\u00e9s por diferentes causas, como el exceso de calor o la salinidad, genera distintas modificaciones en las histonas, apuntando as\u00ed a una respuesta \u201cpersonalizada\u201d para adaptarse a cada tipo de estr\u00e9s. El estudio se ha llevado a cabo en la levadura Saccharomyces cerevisiae, un organismo modelo muy utilizado en biomedicina.<\/p>\n<p>\u201cLas modificaciones en las histonas que regulan la expresi\u00f3n de los genes en condiciones normales se est\u00e1n estudiando mucho\u201d dice Eul\u00e0lia de Nadal. \u201cSin embargo, el papel de las histonas en respuestas al estr\u00e9s celular, que deben ser muy r\u00e1pidas y din\u00e1micas, se conoc\u00eda muy poco, y es importante porque la regulaci\u00f3n de las histonas se asocia a un amplio abanico de enfermedades\u201d, concluye.<\/p>\n<p><strong>\u25ba Art\u00edculo de referencia: <\/strong>Cristina Vi\u00e9itez, Gerard Mart\u00ednez-Cebri\u00e1n, Carme Sol\u00e9, Ren\u00e9 B\u00f6ttcher, Clement M Potel, Mikhail M Savitski, Sara Onnebo, Marc Fabregat, Ali Shilatifard, Francesc Posas, Eul\u00e0lia de Nadal.\u00a0<a href=\"https:\/\/academic.oup.com\/nar\/article\/48\/7\/3455\/5739122\" style=\"font-weight: 200\" target=\"_blank\" rel=\"noopener noreferrer\">A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress<\/a>. Nucleic Acids Research (2020) DOI: 10.1093\/nar\/gkaa081<\/p>\n<p><strong>\u25ba M\u00e1s\u00a0informaci\u00f3n:<\/strong> web del <a href=\"https:\/\/www.irbbarcelona.org\/es\/news\/las-histonas-y-sus-modificaciones-son-clave-para-la-adaptacion-al-estres-celular\" target=\"_blank\" rel=\"noopener noreferrer\">I<\/a><a href=\"https:\/\/www.irbbarcelona.org\/ca\/news\/les-histones-i-les-seves-modificacions-son-clau-per-a-ladaptacio-a-lestres-cellular\" target=\"_blank\" rel=\"noopener noreferrer\">RB Barcelona [+]<\/a><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El laboratorio de Se\u00f1alizaci\u00f3n Celular del lInstituto de Investigaci\u00f3n Biom\u00e9dica (<a href=\"https:\/\/www.irbbarcelona.org\/es\/news\/las-histonas-y-sus-modificaciones-son-clave-para-la-adaptacion-al-estres-celular\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona<\/a>), que lideran Eul\u00e0lia de Nadal y Francesc Posas en el Parc Cient\u00edfic de Barcelona, ha identificado m\u00e1s de 200 regiones (amino\u00e1cidos) en las histonas, que son responsables de regular la respuesta al estr\u00e9s celular. El estudio se\u00f1ala que, seg\u00fan el tipo de estr\u00e9s celular, se responde mediante distintas modificaciones en las histonas.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":26488,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-39004","post","type-post","status-publish","format-standard","has-post-thumbnail","category-sin-categorizar"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Las histonas y sus modificaciones son clave para la adaptaci\u00f3n al estr\u00e9s celular - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/es\/las-histonas-y-sus-modificaciones-son-clave-para-la-adaptacion-al-estres-celular\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Las histonas y sus modificaciones son clave para la adaptaci\u00f3n al estr\u00e9s celular - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"El laboratorio de Se\u00f1alizaci\u00f3n Celular del lInstituto de Investigaci\u00f3n Biom\u00e9dica (IRB Barcelona), que lideran Eul\u00e0lia de Nadal y Francesc Posas en el Parc Cient\u00edfic de Barcelona, ha identificado m\u00e1s de 200 regiones (amino\u00e1cidos) en las histonas, que son responsables de regular la respuesta al estr\u00e9s celular. 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