{"id":38822,"date":"2016-10-04T00:00:00","date_gmt":"2016-10-03T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/\/identifican-una-molecula-clave-en-el-desarrollo-de-la-psoriasis\/"},"modified":"2020-11-16T16:21:36","modified_gmt":"2020-11-16T15:21:36","slug":"identifican-una-molecula-clave-en-el-desarrollo-de-la-psoriasis","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/es\/identifican-una-molecula-clave-en-el-desarrollo-de-la-psoriasis\/","title":{"rendered":"Identifican una mol\u00e9cula clave en el desarrollo de la psoriasis"},"content":{"rendered":"<p>El estudio muestra que la piel de pacientes con psoriasis experimenta un fuerte aumento de la expresi\u00f3n de\u00a0TREX2\u00a0que se concentra en el n\u00facleo celular de los queratinocitos \u2014las c\u00e9lulas m\u00e1s abundantes de la piel\u2014, que proliferan, mueren y se diferencian de forma aberrante. Por tanto, los resultados sugieren una funci\u00f3n importante de este gen en el procesamiento del ADN.<\/p>\n<p>\u00abEn nuestro trabajo, ponemos de manifiesto el papel fundamental de\u00a0TREX2\u00a0en la degradaci\u00f3n del ADN y la consiguiente muerte celular del queratinocito, lo que influye en la respuesta inmunitaria de la piel. La liberaci\u00f3n de varias se\u00f1ales por parte de las c\u00e9lulas de la piel que se est\u00e1n muriendo contribuye a generar y amplificar la respuesta inmunitaria cr\u00f3nica y la hiperproliferaci\u00f3n y diferenciaci\u00f3n anormal de la epidermis\u00bb, explica el primer autor del trabajo, Joan Manils, miembro del Departamento citado y ahora investigador posdoctoral en el Instituto de Ciencias Biom\u00e9dicas del Trinity College (Irlanda).<\/p>\n<p>Los resultados definen\u00a0TREX2\u00a0como una potencial diana terap\u00e9utica para abordar esta enfermedad con una estrategia diferente y m\u00e1s focalizada. \u00abLa mayor\u00eda de tratamientos actuales est\u00e1n dirigidos a bloquear la acci\u00f3n del sistema inmunitario, y si bien dan buenos resultados, son tratamientos de car\u00e1cter cr\u00f3nico y comprometen la respuesta inmunitaria del enfermo\u00bb, explica Francisco Ciruela, coautor del estudio, profesor del Departamento de Patolog\u00eda y Terap\u00e9utica Experimental de la UB y jefe del Grupo de Investigaci\u00f3n de Neurofarmacolog\u00eda y Dolor en el IDIBELL.<\/p>\n<p>El pr\u00f3ximo objetivo de los investigadores ser\u00e1 descifrar el mecanismo de acci\u00f3n completo de\u00a0TREX2\u00a0en el desarrollo y mantenimiento de la psoriasis con el fin de dise\u00f1ar estrategias terap\u00e9uticas para tratar la enfermedad.<\/p>\n<p><strong>\u2022 M\u00e1s informaci\u00f3n en la\u00a0<a href=\"http:\/\/www.ub.edu\/web\/ub\/es\/menu_eines\/noticies\/2016\/10\/003.html?\" target=\"_blank\" rel=\"noopener noreferrer\">web de la UB [+]<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudio publicado en la revista cient\u00edfica<a href=\"http:\/\/www.jidonline.org\/article\/S0022-202X(16)31961-3\/pdf\" target=\"_self\" rel=\"noopener noreferrer\">\u00a0<\/a>Journal of Investigative Dermatology\u00a0ha identificado una diana terap\u00e9utica potencial para tratar la psoriasi. El trabajo demuestra que el gen TREX2 posee un papel relevante en la respuesta inflamatoria que se desencadena durante la enfermedad. En la investigaci\u00f3n \u2013liderada por investigadores del Departamento de Patolog\u00eda y Terap\u00e9utica Experimental de la<a href=\"http:\/\/www.ub.edu\/medicina\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u00a0Facultad de Medicina y Ciencias de la Salud<\/a>\u00a0de la Universidad de Barcelona y del<a href=\"http:\/\/www.idibell.cat\/ca\" target=\"_self\" rel=\"noopener noreferrer\">\u00a0<\/a>Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (<a href=\"http:\/\/www.idibell.cat\/ca\" target=\"_blank\" rel=\"noopener noreferrer\">IDIBELL<\/a>)\u2013 tambi\u00e9n participan expertos de los\u00a0Centros Cient\u00edficos y Tecnol\u00f3gicos de la UB (<a href=\"http:\/\/www.pcb.ub.edu\/portal\/es\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000152&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_tab%3D1%26_cercador_WAR_empleatsempresesportlet_keywords%3Dcentres\" target=\"_blank\" rel=\"noopener noreferrer\">CCiTUB<\/a>)\u00a0con sede en el Parc Cient\u00edfic de Barcelona (PCB).<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":25773,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-38822","post","type-post","status-publish","format-standard","has-post-thumbnail","category-sin-categorizar"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Identifican una mol\u00e9cula clave en el desarrollo de la psoriasis - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/es\/identifican-una-molecula-clave-en-el-desarrollo-de-la-psoriasis\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identifican una mol\u00e9cula clave en el desarrollo de la psoriasis - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Un estudio publicado en la revista cient\u00edfica\u00a0Journal of Investigative Dermatology\u00a0ha identificado una diana terap\u00e9utica potencial para tratar la psoriasi. El trabajo demuestra que el gen TREX2 posee un papel relevante en la respuesta inflamatoria que se desencadena durante la enfermedad. En la investigaci\u00f3n \u2013liderada por investigadores del Departamento de Patolog\u00eda y Terap\u00e9utica Experimental de la\u00a0Facultad de Medicina y Ciencias de la Salud\u00a0de la Universidad de Barcelona y del\u00a0Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL)\u2013 tambi\u00e9n participan expertos de los\u00a0Centros Cient\u00edficos y Tecnol\u00f3gicos de la UB (CCiTUB)\u00a0con sede en el Parc Cient\u00edfic de Barcelona (PCB). \u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pcb.ub.edu\/es\/identifican-una-molecula-clave-en-el-desarrollo-de-la-psoriasis\/\" \/>\n<meta property=\"og:site_name\" content=\"Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"article:published_time\" content=\"2016-10-03T23:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-16T15:21:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2016\/10\/16049220425fa92aba190dd.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"700\" \/>\n\t<meta property=\"og:image:height\" content=\"427\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"adminpcb\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"adminpcb\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/identifican-una-molecula-clave-en-el-desarrollo-de-la-psoriasis\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/identifican-una-molecula-clave-en-el-desarrollo-de-la-psoriasis\\\/\"},\"author\":{\"name\":\"adminpcb\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/d13cab05cd0a75b17fddca8496481021\"},\"headline\":\"Identifican una mol\u00e9cula clave en el desarrollo de la psoriasis\",\"datePublished\":\"2016-10-03T23:00:00+00:00\",\"dateModified\":\"2020-11-16T15:21:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/identifican-una-molecula-clave-en-el-desarrollo-de-la-psoriasis\\\/\"},\"wordCount\":321,\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/identifican-una-molecula-clave-en-el-desarrollo-de-la-psoriasis\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2016\\\/10\\\/16049220425fa92aba190dd.jpeg\",\"articleSection\":[\"Sin categorizar\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/identifican-una-molecula-clave-en-el-desarrollo-de-la-psoriasis\\\/\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/identifican-una-molecula-clave-en-el-desarrollo-de-la-psoriasis\\\/\",\"name\":\"Identifican una mol\u00e9cula clave en el desarrollo de la psoriasis - 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