{"id":37952,"date":"2013-05-21T00:00:00","date_gmt":"2013-05-20T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/\/descubierto-un-nuevo-factor-de-control-de-la-senescencia-celular-inducida-por-oncogenes\/"},"modified":"2020-11-16T16:18:16","modified_gmt":"2020-11-16T15:18:16","slug":"descubierto-un-nuevo-factor-de-control-de-la-senescencia-celular-inducida-por-oncogenes","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/es\/descubierto-un-nuevo-factor-de-control-de-la-senescencia-celular-inducida-por-oncogenes\/","title":{"rendered":"Descubierto un nuevo factor de control de la senescencia celular inducida por oncogenes"},"content":{"rendered":"<p>\u00bb<\/p>\n<div class=\"col-sm-6 detall-noticia-imatges\">\n<div class=\"row\">\n<div class=\"item active one-image\">\n\t\t\t\t\t\t<a class=\"icon-search\" href='http:\/\/www.pcb.ub.edu\/\/wp-content\/uploads\/2020\/11\/1369153973103.jpg'><\/a><br \/>\n\t\t\t\t\t\t<img src='http:\/\/www.pcb.ub.edu\/\/wp-content\/uploads\/2020\/11\/1369153973103.jpg' \/>\n\t\t\t\t\t<\/div><\/div><\/div>\n<p>\t\t\tLa senescencia celular, descrita hace m\u00e1s de cuarenta a\u00f1os por Paul Moorhead y Leonard Hayflick, es un mecanismo de protecci\u00f3n que impide la proliferaci\u00f3n de c\u00e9lulas potencialmente cancer\u00edgenas. Este proceso act\u00faa como un freno molecular a la progresi\u00f3n de c\u00e9lulas tumorales y puede originarse como respuesta a diferentes factores  (oncog\u00e9n, estr\u00e9s oxidativo, alteraci\u00f3n de los tel\u00f3meros, etc.). Tal como explica la catedr\u00e1tica Marta Cascante, directora del Grupo de Investigaci\u00f3n Consolidado de Bioqu\u00edmica Integrativa de la UB y distinguida con el ICREA Academia 2010, \u00abcomo respuesta ante  la mutaci\u00f3n de un oncog\u00e9n, la c\u00e9lula puede activar mecanismos de protecci\u00f3n y entrar en una fase denominada de senescencia inducida por oncogenes que act\u00faa como un mecanismo de defensa o freno a  la progresi\u00f3n tumoral. En este estado, la c\u00e9lula deja de dividirse, manteni\u00e9ndose en un estado premaligno. <\/p>\n<p> Sin embargo, cuando este freno no funciona correctamente, se produce la transformaci\u00f3n maligna y puede aparecer un tumor. Identificar cu\u00e1les son los mecanismos que regulan este estadio celular es decisivo para evitar la formaci\u00f3n del tumor o revertirlo, y para poder definir nuevas estrategias terap\u00e9uticas en un futuro\u00bb.   <\/p>\n<p> <a href=\"http:\/\/www.ub.edu\/web\/ub\/es\/menu_eines\/noticies\/2013\/05\/055.html?\" target=\"_blank\" class=\"email\" rel=\"noopener noreferrer\">Enlace a la noticia [+]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un art\u00edculo publicado en la revista Nature describe el papel esencial de la Piruvato deshidrogenasa (PDH) \u2014una enzima b\u00e1sica del metabolismo energ\u00e9tico de la c\u00e9lula\u2014 en la regulaci\u00f3n de la senescencia celular inducida por el oncog\u00e9n BRAF, que suele aparecer mutado en el melanoma y en otros c\u00e1nceres. En el estudio han participado Marta Cascante y Vitaly Selivanov, del Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular de la Facultad de Biolog\u00eda de la UB y del Instituto de Biomedicina de la UB (IBUB) \u2013presente en el Parc Cient\u00edfic de Barcelona\u2013 adscritos al campus excelencia internacional Barcelona Knowledge Campus (BKC).<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-37952","post","type-post","status-publish","format-standard","category-sin-categorizar"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Descubierto un nuevo factor de control de la senescencia celular inducida por oncogenes - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/es\/descubierto-un-nuevo-factor-de-control-de-la-senescencia-celular-inducida-por-oncogenes\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Descubierto un nuevo factor de control de la senescencia celular inducida por oncogenes - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Un art\u00edculo publicado en la revista Nature describe el papel esencial de la Piruvato deshidrogenasa (PDH) \u2014una enzima b\u00e1sica del metabolismo energ\u00e9tico de la c\u00e9lula\u2014 en la regulaci\u00f3n de la senescencia celular inducida por el oncog\u00e9n BRAF, que suele aparecer mutado en el melanoma y en otros c\u00e1nceres. En el estudio han participado Marta Cascante y Vitaly Selivanov, del Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular de la Facultad de Biolog\u00eda de la UB y del Instituto de Biomedicina de la UB (IBUB) \u2013presente en el Parc Cient\u00edfic de Barcelona\u2013 adscritos al campus excelencia internacional Barcelona Knowledge Campus (BKC).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pcb.ub.edu\/es\/descubierto-un-nuevo-factor-de-control-de-la-senescencia-celular-inducida-por-oncogenes\/\" \/>\n<meta property=\"og:site_name\" content=\"Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"article:published_time\" content=\"2013-05-20T23:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-16T15:18:16+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.pcb.ub.edu\/\/wp-content\/uploads\/2020\/11\/1369153973103.jpg\" \/>\n<meta name=\"author\" content=\"adminpcb\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"adminpcb\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descubierto-un-nuevo-factor-de-control-de-la-senescencia-celular-inducida-por-oncogenes\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descubierto-un-nuevo-factor-de-control-de-la-senescencia-celular-inducida-por-oncogenes\\\/\"},\"author\":{\"name\":\"adminpcb\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/d13cab05cd0a75b17fddca8496481021\"},\"headline\":\"Descubierto un nuevo factor de control de la senescencia celular inducida por oncogenes\",\"datePublished\":\"2013-05-20T23:00:00+00:00\",\"dateModified\":\"2020-11-16T15:18:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descubierto-un-nuevo-factor-de-control-de-la-senescencia-celular-inducida-por-oncogenes\\\/\"},\"wordCount\":227,\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descubierto-un-nuevo-factor-de-control-de-la-senescencia-celular-inducida-por-oncogenes\\\/#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/www.pcb.ub.edu\\\/\\\/wp-content\\\/uploads\\\/2020\\\/11\\\/1369153973103.jpg\",\"articleSection\":[\"Sin categorizar\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descubierto-un-nuevo-factor-de-control-de-la-senescencia-celular-inducida-por-oncogenes\\\/\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descubierto-un-nuevo-factor-de-control-de-la-senescencia-celular-inducida-por-oncogenes\\\/\",\"name\":\"Descubierto un nuevo factor de control de la senescencia celular inducida por oncogenes - 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