{"id":37915,"date":"2013-03-19T00:00:00","date_gmt":"2013-03-18T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/\/descifrado-un-mecanismo-clave-en-la-virulencia-de-las-infecciones-fungicas\/"},"modified":"2020-11-16T16:18:09","modified_gmt":"2020-11-16T15:18:09","slug":"descifrado-un-mecanismo-clave-en-la-virulencia-de-las-infecciones-fungicas","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/es\/descifrado-un-mecanismo-clave-en-la-virulencia-de-las-infecciones-fungicas\/","title":{"rendered":"Descifrado un mecanismo clave en la virulencia de las infecciones f\u00fangicas"},"content":{"rendered":"<p>\u00bb<\/p>\n<div class=\"col-sm-6 detall-noticia-imatges\">\n<div class=\"row\">\n<div class=\"item active one-image\">\n\t\t\t\t\t\t<a class=\"icon-search\" href='http:\/\/www.pcb.ub.edu\/\/wp-content\/uploads\/2020\/11\/1363689108888.jpg'><\/a><br \/>\n\t\t\t\t\t\t<img src='http:\/\/www.pcb.ub.edu\/\/wp-content\/uploads\/2020\/11\/1363689108888.jpg' \/>\n\t\t\t\t\t<\/div><\/div><\/div>\n<p>\t\t\tDescubiertas en 1957 por los expertos Marghoses y Vallee, las metalotione\u00ednas (MT) son unas prote\u00ednas de bajo peso molecular que contienen muchos residuos del amino\u00e1cido ciste\u00edna. Gracias a esta estructura, pueden enlazar iones met\u00e1licos y actuar como agentes quelantes \u2014compuestos que capturan metales\u2014 para captar y distribuir metales de inter\u00e9s biol\u00f3gico (cobre, zinc, cadmio y mercurio, entre otros). Las MT son prote\u00ednas muy heterog\u00e9neas y polim\u00f3rficas, y se encuentran en todo tipo de organismos (procariotas, hongos, vegetales, vertebrados, etc.), donde facilitan el proceso de destoxificaci\u00f3n o eliminaci\u00f3n de metales t\u00f3xicos y ayudan a modular la respuesta fisiol\u00f3gica del organismo ante la carencia o el exceso de metales.  <\/p>\n<p> En investigaciones previas se hab\u00edan identificado unas prote\u00ednas producidas por el <i>hongo C.<\/i> neoformans en respuesta a niveles elevados de cobre. \u00abPor primera vez, el nuevo trabajo constata que estas prote\u00ednas son metalotione\u00ednas, y que son factores cr\u00edticos para la colonizaci\u00f3n y la virulencia del pat\u00f3geno\u00bb, explica S\u00edlvia Atrian. <\/p>\n<p> Ahora este trabajo revela que la expresi\u00f3n g\u00e9nica de las MT del <i>C. neoformans<\/i> se activa durante la infecci\u00f3n pulmonar. Tal como explica la investigadora Anna Esparto, \u00abun golpe el hongo es capaz de infectar los pulmones, los macr\u00f3fagos, entre otras estrategias de defensa, crean un ambiente rico al cocer para luchar contra la infecci\u00f3n. En este entorno con niveles altos de cocer, se activa la s\u00edntesis de las MT del hongo, que son capaces de capturar el cobre y permitir, as\u00ed, el adelanto de la infecci\u00f3n en un ambiente hostil para el pat\u00f3geno\u00bb.  <\/p>\n<p><p> <a href=\"http:\/\/www.ub.edu\/web\/ub\/es\/menu_eines\/noticies\/2013\/03\/061.html?\" target=\"_blank\" class=\"email\" rel=\"noopener noreferrer\">Enlace a la noticia [+]<\/a>      <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Las metalotione\u00ednas, unas prote\u00ednas capaces de capturar iones met\u00e1licos, son un factor clave para la virulencia del hongo <i>Cryptococcus neoformans<\/i>, un pat\u00f3geno que causa graves infecciones en personas con la inmunidad alterada (enfermos de sida, receptores de trasplantes, etc.). Esta es una de las conclusiones principales de un estudio publicado en la revista Cell, Host &amp; Microbe, en el que han participado las investigadoras S\u00edlvia Atrian y Anna Espart, del Departamento de Gen\u00e9tica y del Instituto de Biomedicina de la UB (IBUB) \u2013ubicado en el Parc Cient\u00edfic de Barcelona\u2013, adscritos al campus de excelencia internacional BKC. <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-37915","post","type-post","status-publish","format-standard","category-sin-categorizar"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Descifrado un mecanismo clave en la virulencia de las infecciones f\u00fangicas - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/es\/descifrado-un-mecanismo-clave-en-la-virulencia-de-las-infecciones-fungicas\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Descifrado un mecanismo clave en la virulencia de las infecciones f\u00fangicas - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Las metalotione\u00ednas, unas prote\u00ednas capaces de capturar iones met\u00e1licos, son un factor clave para la virulencia del hongo Cryptococcus neoformans, un pat\u00f3geno que causa graves infecciones en personas con la inmunidad alterada (enfermos de sida, receptores de trasplantes, etc.). Esta es una de las conclusiones principales de un estudio publicado en la revista Cell, Host &amp; Microbe, en el que han participado las investigadoras S\u00edlvia Atrian y Anna Espart, del Departamento de Gen\u00e9tica y del Instituto de Biomedicina de la UB (IBUB) \u2013ubicado en el Parc Cient\u00edfic de Barcelona\u2013, adscritos al campus de excelencia internacional BKC.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pcb.ub.edu\/es\/descifrado-un-mecanismo-clave-en-la-virulencia-de-las-infecciones-fungicas\/\" \/>\n<meta property=\"og:site_name\" content=\"Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"article:published_time\" content=\"2013-03-18T23:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-16T15:18:09+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.pcb.ub.edu\/\/wp-content\/uploads\/2020\/11\/1363689108888.jpg\" \/>\n<meta name=\"author\" content=\"adminpcb\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"adminpcb\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descifrado-un-mecanismo-clave-en-la-virulencia-de-las-infecciones-fungicas\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descifrado-un-mecanismo-clave-en-la-virulencia-de-las-infecciones-fungicas\\\/\"},\"author\":{\"name\":\"adminpcb\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/d13cab05cd0a75b17fddca8496481021\"},\"headline\":\"Descifrado un mecanismo clave en la virulencia de las infecciones f\u00fangicas\",\"datePublished\":\"2013-03-18T23:00:00+00:00\",\"dateModified\":\"2020-11-16T15:18:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descifrado-un-mecanismo-clave-en-la-virulencia-de-las-infecciones-fungicas\\\/\"},\"wordCount\":295,\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descifrado-un-mecanismo-clave-en-la-virulencia-de-las-infecciones-fungicas\\\/#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/www.pcb.ub.edu\\\/\\\/wp-content\\\/uploads\\\/2020\\\/11\\\/1363689108888.jpg\",\"articleSection\":[\"Sin categorizar\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descifrado-un-mecanismo-clave-en-la-virulencia-de-las-infecciones-fungicas\\\/\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/descifrado-un-mecanismo-clave-en-la-virulencia-de-las-infecciones-fungicas\\\/\",\"name\":\"Descifrado un mecanismo clave en la virulencia de las infecciones f\u00fangicas - 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