<\/a>
\n\t\t\t\t\t\t
\n\t\t\t\t\t<\/div><\/div><\/div>\n\t\t\tLos investigadores describen que CPEB1 acorta una regi\u00f3n muy espec\u00edfica de los RNA (los RNA son las mol\u00e9culas que llevan la informaci\u00f3n de los genes para sintetizar prote\u00ednas). Esta regi\u00f3n que recorta CPBE1 contiene la mayor parte de las se\u00f1ales que determinan si ese RNA debe traducirse o no a prote\u00edna. \u00abCPEB1 \u00abquita los frenos\u00bb a cientos de RNA que promueven desdiferenciaci\u00f3n y proliferaci\u00f3n celular permitiendo que se traduzcan a prote\u00edna, pero adem\u00e1s de recortarle los frenos en el n\u00facleo, acompa\u00f1a al RNA hasta el citoplasma de la c\u00e9lula, d\u00f3nde acelera la producci\u00f3n de esas prote\u00ednas\u00bb, explica el investigador s\u00e9nior del art\u00edculo Ra\u00fal M\u00e9ndez, jefe del grupo \u00abControl Traduccional del Ciclo Celular y Diferenciaci\u00f3n\u00bb en el IRB Barcelona. <\/p>\n
Este trabajo suma as\u00ed evidencias sobre la potencia de las CPEB como dianas terap\u00e9uticas, ya que M\u00e9ndez identific\u00f3 en 2011 que la prote\u00edna CPEB 4 \u00abencend\u00eda\u00bb cientos de genes vinculados al crecimiento tumoral, en una trabajo publicado en Nature Medicine. El trabajo de ahora explica porqu\u00e9 CPEB4 estaba sobreexpresada en tumores y es debido a que CPEB1 tambi\u00e9n le ha \u00abrecortado los frenos\u00bb. \u00abQue estas prote\u00ednas se controlen las unas a las otras tambi\u00e9n es bueno desde un punto de vista terap\u00e9utico\u00bb, declara M\u00e9ndez \u00abporque una inhibici\u00f3n parcial por un f\u00e1rmaco se amplificar\u00eda pudiendo reprogramar la c\u00e9lula tumoral. La amplificaci\u00f3n deber\u00eda hacer m\u00e1s f\u00e1cil encontrar un compuesto viable\u00bb. <\/p>\n
El laboratorio ha desarrollado un screening o rastreo de mol\u00e9culas terap\u00e9uticas para encontrar un f\u00e1rmaco capaz de inhibir la acci\u00f3n de la CPEB en tumores con los menores efectos secundarios sobre las c\u00e9lulas sanas. \u00abHoy por hoy no hay ning\u00fan f\u00e1rmaco que incida a este nivel del proceso de regulaci\u00f3n de la expresi\u00f3n g\u00e9nica con lo que estamos abriendo una ventana terap\u00e9utica totalmente pionera. Estamos muy esperanzados con el potencial de las CPEB como diana\u00bb, declara M\u00e9ndez. <\/p>\n
Enlace a la noticia [+]<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"El laboratorio liderado por Ra\u00fal M\u00e9ndez, investigador ICREA en el Institut de Recerca Biom\u00e8dica (IRB Barcelona) \u2013con sede en el Parc Cient\u00edfic de Barcelona\u2013 ha publicado en Nature un estudio que describe un mecanismo dirigido por la prote\u00edna CPEB1 que afecta a m\u00e1s de 200 genes relacionados con proliferaci\u00f3n celular y promoci\u00f3n tumoral. El hallazgo realizado en c\u00e9lulas tumorales del linfoma de Hodgkin se postula como un mecanismo de regulaci\u00f3n general de promoci\u00f3n del c\u00e1ncer. <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-37903","post","type-post","status-publish","format-standard","category-sin-categorizar"],"acf":[],"yoast_head":"\n
Investigadores del IRB Barcelona hallan un mecanismo general que acelera el desarrollo tumoral - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/es\/investigadores-del-irb-barcelona-hallan-un-mecanismo-general-que-acelera-el-desarrollo-tumoral\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadores del IRB Barcelona hallan un mecanismo general que acelera el desarrollo tumoral - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"El laboratorio liderado por Ra\u00fal M\u00e9ndez, investigador ICREA en el Institut de Recerca Biom\u00e8dica (IRB Barcelona) \u2013con sede en el Parc Cient\u00edfic de Barcelona\u2013 ha publicado en Nature un estudio que describe un mecanismo dirigido por la prote\u00edna CPEB1 que afecta a m\u00e1s de 200 genes relacionados con proliferaci\u00f3n celular y promoci\u00f3n tumoral. 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