<\/a>
\n\t\t\t\t\t\t
\n\t\t\t\t\t<\/div><\/div><\/div>\n\t\t\tDado que la inmensa mayor\u00eda de genes de Drosophila est\u00e1n conservados tambi\u00e9n en ratones y humanos, los resultados obtenidos en la mosca podr\u00edan convertirse en motor para que se investiguen en modelos m\u00e1s cercanos a la cl\u00ednica. La revista Proceedings of the National Academy of Sciences (PNAS) de EEUU avanza los datos del estudio en su edici\u00f3n digital esta semana. <\/p>\n
El cient\u00edfico argentino Andr\u00e9s Dekanty, investigador Juan de la Cierva del laboratorio de Mil\u00e1n y primer autor del art\u00edculo, explica que \u00abpor primera vez, disponemos de un modelo gen\u00e9tico que nos permitir\u00e1 entender los eventos que van desde la acumulaci\u00f3n de aberraciones gen\u00f3micas de una c\u00e9lula al comportamiento tumoral\u00bb. <\/p>\n
El equipo de Mil\u00e1n provoc\u00f3 inestabilidad gen\u00f3mica en algunas c\u00e9lulas del ala de la mosca. Seguidamente, permiti\u00f3 que esas c\u00e9lulas con un n\u00famero de cromosomas aberrantes (c\u00e9lulas aneuploides) no sucumbieran ante los mecanismos naturales de autodefensa celular, y sobrevivieran. A partir de ah\u00ed, observaron que las c\u00e9lulas se desprend\u00edan del tejido, adquir\u00edan capacidad de movimiento, activaban el crecimiento anormal de c\u00e9lulas colindantes, degradaban la membrana basal que las manten\u00eda en su sitio, escapando del tejido, e incluso eran capaces de invadir tejidos vecinos. <\/p>\n
\u00abTodos estos eventos son paralelos a lo observado en un c\u00e1ncer, as\u00ed que este modelo de mosca nos servir\u00eda para describir cada uno de los genes y mol\u00e9culas involucrados en desprendimiento del tejido epitelial (delaminaci\u00f3n), motilidad, crecimiento anormal, degradaci\u00f3n de la membrana basal e invasi\u00f3n\u00bb, describe Mil\u00e1n. <\/p>\n
\u00abPero hay algo m\u00e1s profundo en este estudio, un debate conceptual fundamental\u00bb, apuntan los investigadores. Seg\u00fan explican los cient\u00edficos, esta es la primera vez que se describen esos fen\u00f3menos ligados a inestabilidad gen\u00f3mica. \u00abEsto nos lleva a proponer algo que todav\u00eda no se ha podido estudiar a fondo y que ahora convendr\u00eda tomarse muy en serio: \u00bfes la inestabilidad gen\u00f3mica causa de tumorog\u00e9nesis?\u00bb, expone Mil\u00e1n. <\/p>\n
M\u00e1s informaci\u00f3n [+]<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"En el ala de una mosca podr\u00eda estar la llave para dilucidar a nivel gen\u00e9tico y molecular cada uno de los eventos que transforman una c\u00e9lula normal en tumoral. Un trabajo realizado por cient\u00edficos del Institut de Recerca Biom\u00e8dica (IRB Barcelona), liderados por el investigador ICREA Marco Mil\u00e1n, en Drosophila melanogaster consigue reproducir cada uno de los pasos conocidos para que una c\u00e9lula sana acabe generando un tumor. Los investigadores ponen al alcance de la comunidad cient\u00edfica un modelo gen\u00e9tico barato y eficaz que permitir\u00eda escrutar los genes y mol\u00e9culas involucrados en cada uno de esos episodios. <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-37855","post","type-post","status-publish","format-standard","category-sin-categorizar"],"acf":[],"yoast_head":"\n
Crean una mosca para estudiar al detalle c\u00f3mo una c\u00e9lula normal se transforma en tumoral - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/es\/crean-una-mosca-para-estudiar-al-detalle-como-una-celula-normal-se-transforma-en-tumoral\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Crean una mosca para estudiar al detalle c\u00f3mo una c\u00e9lula normal se transforma en tumoral - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"En el ala de una mosca podr\u00eda estar la llave para dilucidar a nivel gen\u00e9tico y molecular cada uno de los eventos que transforman una c\u00e9lula normal en tumoral. 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