<\/a>
\n\t\t\t\t\t\t
\n\t\t\t\t\t<\/div><\/div><\/div>\n\t\t\tEl articulo, publicado en la revista eCells and Materials (eCM), y encabezado por Elisabeth Engel, revela con gran detalle como el compuesto de cristal de fosfato c\u00e1lcico\/PLA de este biomaterial estimula la movilizaci\u00f3n y diferenciaci\u00f3n de las c\u00e9lulas progenitoras endoteliales – las que se convierten en las c\u00e9lulas que componen el revestimiento de los vasos sangu\u00edneos. <\/p>\n
\u00abEn la medicina regenerativa, la reparaci\u00f3n tisular exitosa depende de poder recrear el medio adecuado, de forma que el biomaterial no s\u00f3lo act\u00fae como andamio para el tejido nuevo, sino que tambi\u00e9n contribuya a la activaci\u00f3n del proceso de regeneraci\u00f3n,\u00bb explica Elisabeth. \u00abHemos comprendido la importancia del micromedio local en la determinaci\u00f3n de lo que les sucede a las c\u00e9lulas gracias a recientes avances en la comprensi\u00f3n de la biolog\u00eda de las c\u00e9lulas madre y la mecanosensaci\u00f3n. Teniendo esto en cuenta, hemos conseguido desarrollar un biomaterial bioactivo y biodegradable que imita un micromedio como el de la regeneraci\u00f3n \u00f3sea que activa las se\u00f1ales necesarias para guiar el proceso regenerativo\u00bb, aclara la investigadora. <\/p>\n
Su compuesto de bajo coste y f\u00e1cil elaboraci\u00f3n env\u00eda se\u00f1ales bioqu\u00edmicas y mec\u00e1nicas para activar dos v\u00edas de se\u00f1alizaci\u00f3n celular que ponen en marcha las c\u00e9lulas madre endoteliales provenientes de la m\u00e9dula \u00f3sea. Con el tiempo, se dirigen al lugar correcto, se diferencian en el tipo correcto de c\u00e9lulas y empiezan a ramificarse en las estructuras arb\u00f3reas que asociamos con los vasos sangu\u00edneos. <\/p>\n
Adem\u00e1s de ofrecer nuevas oportunidades terap\u00e9uticas para las aproximaciones a la vascularizaci\u00f3n basadas en los biomateriales y aplicaciones m\u00e9dicas, el descubrimiento ayudar\u00e1 a los investigadores a construir un modelo de las interacciones biol\u00f3gicas subyacentes en la interfaz c\u00e9lula-material para contribuir al dise\u00f1o racional de m\u00e1s biomateriales pro-angiog\u00e9nicos inteligentes. <\/p>\n
Enlace a la noticia<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"Investigadores del grupo de Josep Planell, Biomateriales para Terapias Regenerativas, liderado por Josep Planell, han desarrollado un nuevo biomaterial inteligente que imita el ‘micromedio’ local de la regeneraci\u00f3n \u00f3sea y activa que activa la angiog\u00e9nesis al proporcionar las se\u00f1ales bioqu\u00edmicas y mec\u00e1nicas necesarias para guiar el proceso regenerativo. Es la primera vez que se ha demostrado que un compuesto que contiene un cristal bioactivo y biodegradable est\u00e1 directamente implicado en la angiog\u00e9nesis y la diferenciaci\u00f3n de c\u00e9lulas progenitoras endoteliales. <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-37794","post","type-post","status-publish","format-standard","category-sin-categorizar"],"acf":[],"yoast_head":"\n
Investigadores del IBEC crean un biomaterial inteligente que favorece la angiog\u00e9nesis - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/es\/investigadores-del-ibec-crean-un-biomaterial-inteligente-que-favorece-la-angiogenesis\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadores del IBEC crean un biomaterial inteligente que favorece la angiog\u00e9nesis - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Investigadores del grupo de Josep Planell, Biomateriales para Terapias Regenerativas, liderado por Josep Planell, han desarrollado un nuevo biomaterial inteligente que imita el 'micromedio' local de la regeneraci\u00f3n \u00f3sea y activa que activa la angiog\u00e9nesis al proporcionar las se\u00f1ales bioqu\u00edmicas y mec\u00e1nicas necesarias para guiar el proceso regenerativo. 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