{"id":99271,"date":"2024-10-21T12:39:50","date_gmt":"2024-10-21T10:39:50","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/atomic-sensors-unveil-hidden-dynamics-of-molecular-polarization\/"},"modified":"2024-10-22T15:19:44","modified_gmt":"2024-10-22T13:19:44","slug":"atomic-sensors-unveil-hidden-dynamics-of-molecular-polarization","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/atomic-sensors-unveil-hidden-dynamics-of-molecular-polarization\/","title":{"rendered":"Atomic sensors unveil hidden dynamics of molecular polarization"},"content":{"rendered":"<p><strong>Researchers from the <a href=\"https:\/\/www.pcb.ub.edu\/en\/empresa\/institut-de-bioenginyeria-de-catalunya-ibec\/\" target=\"_blank\" rel=\"noopener\">Institute for Bioengineering of Catalonia (IBEC)<\/a>, based in the Barcelona Science Park, and <a href=\"https:\/\/www.icfo.eu\/\" target=\"_blank\" rel=\"noopener\">ICFO &#8211; The Institute of Photonic Sciences <\/a>demonstrate the ability of atomic sensors to non-destructively monitor, measure and optimize nuclear spin hyperpolarization of some clinically relevant molecules in real-time. These features, reported in PNAS, could enhance and reduce costs of quality controls used in clinical magnetic resonance imaging.<\/strong><\/p>\n<p>Magnetic resonance imaging (MRI) has long been a cornerstone of modern medicine, providing highly detailed images of internal organs and tissues. MRI machines, those large, tube-shaped magnets commonly found in hospitals, use powerful magnets to map the densities of water and fat molecules within the body. In addition to these molecules, other substances like metabolites can also be mapped, but their concentrations are often too low to produce clear images. To overcome this limitation, a technique known as hyperpolarization is employed to enhance the magnetic resonance signal of these substances, making them more visible during MRI scans.<\/p>\n<p>Hyperpolarization involves preparing a substance outside the body in a state where its magnetization\u2014key to creating MRI images\u2014is near its maximum. This process can boost the signal by thousands of times compared to its natural state. Once hyperpolarized, the substance is injected into the patient and transported to the target organ or tissue. However, before this can happen, it is crucial to confirm that the substance is adequately hyperpolarized through rigorous quality control processes.<\/p>\n<p>Current quality control techniques face two significant challenges. First, these methods often reduce the magnetization of the sample during the read-out process, thereby diminishing its ability to enhance the MRI scan. Second, the time required for measurement can be lengthy, during which the substance\u2019s magnetization naturally decays, limiting the opportunity for consecutive measurements. This results in a lack of critical data that could otherwise help maximize the efficiency of hyperpolarization. Furthermore, once the sample is hyperpolarized, there is a risk that it could lose its magnetization during transport to the MRI machine. Traditional quality control techniques, due to their time-consuming nature, may fail to detect this loss in time.<\/p>\n<p>Now, a collaboration of IBEC researchers <strong>Dr. James Eills<\/strong> (now at Forschungszentrum J\u00fclich, Germany) and <strong>Dr. Irene Marco Rius<\/strong> and ICFO researchers\u00a0<strong>ICREA Prof. Morgan W. Mitchell<\/strong>\u00a0and\u00a0<strong>Dr. Michael C. D. Tayler<\/strong>\u00a0has demonstrated how\u00a0atomic sensor techniquesovercome the limitations of conventional sampling when measuring the magnetization of hyperpolarized materials.<\/p>\n<p>In particular, the team used optically pumped atomic magnetometers (OPMs), whose operating principles differ fundamentally from traditional sensors, enabling\u00a0real-time\u00a0detection of the fields produced by hyperpolarized molecules. The nature of OPMs allowed these researchers to perform\u00a0continuous,\u00a0high-resolution\u00a0and\u00a0non-destructive observations\u00a0throughout the entire experiment, including the hyperpolarization process itself.<\/p>\n<p>According to the authors, if the field of hyperpolarization sensing was cinema, previous methods would be like a sequence of still photos, leaving the plot between frozen pictures open to the viewer\u2019s guess. \u201cInstead, our technique is more like a video, were you see the whole story frame by frame. Essentially, you can observe continuously and without resolution limits, and this way you do not miss any details!\u201d, explains <strong>Dr. Michael Tayler<\/strong>, ICFO researcher and co- author of the article.&#8221;The OPM measurements worked beautifully from the start.\u00a0The sensors\u2019 exquisite sensitivity revealed hidden dynamics we hadn\u2019t anticipated, as if they were meant for this purpose.\u00a0The ease of use and the wealth of new information make them a powerful tool for hyperpolarization monitoring&#8221;, he adds.<\/p>\n<p>This method could significantly reduce the cost and logistical challenges of metabolic MRI. If so, this would expand its reach from the handful of specialized research centers where it is currently used, to many hospitals worldwide.<\/p>\n<p>However, the potential of atomic sensors extends far beyond medical imaging. The same non-destructive, real-time tracking system using optically-pumped magnetometers (OPMs) could be applied to monitor macromolecules in chemical processes, study high-energy physics targets, or even optimize spin-based algorithms in quantum computing.<\/p>\n<p>The work represents an advancement in hyperpolarized MRI technology, thanks in large part to the collaborative efforts of\u00a0<a href=\"https:\/\/ibecbarcelona.eu\/molecular-imaging-for-precision-medicine\/\" target=\"_blank\" rel=\"noopener\">IBEC\u2019s Molecular Imaging for Precision Medicine group<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.icfo.eu\/research-group\/8\/q-light-atoms\/home\/437\/\" target=\"_blank\" rel=\"noopener\">ICFO\u2019s Atomic Quantum Optics group<\/a>. IBEC expertise in hyperpolarization methods and ICFO\u2019s expertise in OPM sensing technologies were critical in achieving the results.<\/p>\n<p>\u201cThis is a beautiful example of the new science that can be achieved when researchers from different disciplines work together, and the proximity of IBEC and ICFO meant we were able to collaborate closely and achieve something truly novel\u201d, acknowledges <strong>Dr. James Eills<\/strong>, IBEC researcher and first author of the article.<\/p>\n<p><strong>\u00bb Reference article:<\/strong> Eills J, Mitchell MW, Rius IM, Tayler MCD. Live magnetic observation of parahydrogen hyperpolarization dynamics. Proceedings of the National Academy of Sciences (2024).\u00a0DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1073\/pnas.2410209121\" target=\"_blank\" rel=\"noreferrer noopener\">10.1073\/pnas.2410209121<\/a><\/p>\n<p><strong>\u00bb Link to the news:<\/strong> <a href=\"https:\/\/ibecbarcelona.eu\/atomic-sensors-unveil-hidden-dynamics-of-molecular-polarization\/\" target=\"_blank\" rel=\"noopener\">IBEC website [+]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from the Institute for Bioengineering of Catalonia (IBEC), based in the Barcelona Science Park, and ICFO &#8211; The Institute of Photonic Sciences demonstrate the ability of atomic sensors to&#8230;<\/p>\n","protected":false},"author":14,"featured_media":99257,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-99271","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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