{"id":98383,"date":"2024-09-17T16:33:41","date_gmt":"2024-09-17T14:33:41","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/dna-maps-to-stop-biodiversity-loss\/"},"modified":"2024-09-23T11:35:37","modified_gmt":"2024-09-23T09:35:37","slug":"dna-maps-to-stop-biodiversity-loss","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/dna-maps-to-stop-biodiversity-loss\/","title":{"rendered":"DNA maps to stop biodiversity loss"},"content":{"rendered":"

The\u00a0European Reference Genome Atlas (ERGA)<\/a> Pilot Project unites more than 200 researchers from across Europe to produce reference genomes for 98 species, establishing the basis for generating high-quality DNA maps at scale. The Centro Nacional de An\u00e1lisis Gen\u00f3mico (CNAG)<\/a>, based in the Barcelona Science Park and one of the ERGA genome sequencing hubs, has covered the entire genomic process, from sequencing to chromosome-level assembly and annotation \u00a0for numerous species In Spain and Andorra. This local effort supports the European strategy to meet the challenge of the\u00a0Earth BioGenome Project (EBP)<\/a>, which aims to create a genomic blueprint for 150,000 species around the world.<\/strong><\/p>\n

The loss of biodiversity on the planet is one of the major global threats we face today.\u00a0Currently, over 45,000 species are at risk of extinction (according to the\u00a0IUCN<\/a>\u00a0Red List), with significant repercussions for our ecosystems, human health, bioeconomy, and even our resilience to climate change. In the face of this sixth mass extinction, as experts call it, more than 200 researchers from 33 European countries have decided to adopt the leitmotif ‘Better Together’ to provide a united response to this international challenge.<\/p>\n

This is how the\u00a0European Reference Genome Atlas (ERGA) Pilot Project\u00a0was born, published today in the journal\u00a0NJP Biodiversity.\u00a0This descentralised European network, aimed at generating high-quality reference genomes for species across the continent, is the first step in laying the groundwork for mapping species at scale across Europe.<\/p>\n

In Spain and Andorra, the Centro Nacional de An\u00e1lisis Gen\u00f3mico (CNAG), one of the ERGA genome sequencing hubs, has covered the entire genomic process, from sequencing to chromosome-level assembly and annotation.\u00a0Located in Barcelona, CNAG has obtained chromosome-level genomes for numerous species, such as the sea sponge\u00a0Phakellia ventilabrum<\/em> and the butterflies Coenonympha glycerion<\/em>\u00a0and\u00a0Helleia helle<\/em>. In total, the Pilot Project has generated high-quality reference genomes for 98 European species. This European effort represents ERGA’s first response to the global Earth BioGenome Project (EBP) challenge, which aims to sequence all eukaryotic life on Earth.<\/p>\n

\"\"

The butterfly ‘Coenonympha glycerion’, one of the species that has been part of the ERGA Pilot Project. Photo: Erik Karitsfrom \/ Pexels.<\/p><\/div>\n

CNAG, as a member of the Sequencing and Assembly Committee of ERGA, has also contributed to preparing Europe for the second phase of the Earth BioGenome Project, where the challenge is to sequence 150,000 species worldwide. Establishing sequencing and assembly in a coordinated and scalable manner is crucial for Europe to join this global objective for biodiversity.<\/p>\n

According to Dr. Marta Gut<\/strong>, head of the Sequencing Unit at CNAG: \u201cUsing the new collaborative model introduced by the ERGA Pilot Project, CNAG has integrated into a multicenter environment aiming to build a genomic resource on the scale of the Earth BioGenome Project, offering a unique opportunity to explore and protect biodiversity\u201d.<\/p>\n

One of the keys to biodiversity is hidden in the DNA of species<\/strong><\/h3>\n

The rapid advancement of genomic science has made it a valuable tool for biodiversity conservation. Mapping the genome and uncovering the secrets hidden in the DNA of each species is now possible thanks to next-generation sequencing platforms and complex bioinformatics algorithms. The DNA map of species, with a special focus on the most vulnerable ones, paves the way for biodiversity genomics. This approach enables analyses of species evolution over time and their innate survival capabilities in specific environments, such as their ability to adapt to different temperatures. Despite the availability of these new resources, genomic information is available for only 0.43% of the planet’s eukaryotic species, and 63% of that data is of draft quality.<\/p>\n

The main goal of the ERGA Pilot Project is to create a high-quality reference genome database for all European animals, plants, and fungi. One of the challenges was finding a balance between decentralization and the need for standardization to ensure the highest possible quality of reference genome assemblies that meet EBP metrics.<\/p>\n

\u201cBy using a combination of state-of-the-art genomic technologies, we have obtained the highest-quality reference genomes for these species. This genomic information is extremely useful for studying species interactions and their adaptation to the environment,\u201d explains Dr. Tyler Alioto<\/strong>, the Assembly and Annotation team leader at CNAG.<\/p>\n

To streamline the prioritization of species and track the sample metadata and genomic information available to date, Dr. Alioto<\/strong> and his team have designed an online tool called the ERGA Genome Tracking Console (ERGA-GTC). This tool facilitates the exchange of information between institutions involved in all aspects of reference genome production as well data repositories, allowing users to quickly determine the level of progress made toward the generation of high-quality reference genomes\u00a0 for any species in the pipeline. ERGA-GTC is now being used by scientists from all 33 European countries participating in the project.<\/p>\n

A pioneering initiative for biodiversity in Europe, regardless geographical boundaries<\/strong><\/h3>\n

After years of intense community efforts, ERGA reports the success of its Pilot Project, establishing this pioneering network as a model for decentralised, inclusive, and equitable biodiversity genomics initiatives worldwide. The ERGA Pilot emphasised equity and inclusion, aiming to make genomic research and resources accessible to all, regardless of geographical boundaries. This required overcoming significant challenges, such as working on an international scale, navigating the legal and logistical hurdles of shipping biological samples across borders, and addressing resource disparities between countries. These challenges were worth tackling, as the project provided many participating researchers and countries with their first opportunity to actively engage in generating state-of-the-art reference genomic resources for their native biodiversity.<\/p>\n

 <\/p>\n

In Spain, in addition to CNAG, a broad network of collaborators participated, including CSIC organizations (Instituto de Biolog\u00eda Evolutiva,\u00a0Institut Bot\u00e0nic de Barcelona,\u00a0Museo Nacional de Ciencias Naturales, and\u00a0Estaci\u00f3n Biol\u00f3gica de Do\u00f1ana), as well as the\u00a0Barcelona Supercomputing Center, the\u00a0Institute for Research in Biomedicine, the\u00a0CIBER of Epidemiology and Public Health, and the\u00a0Spanish National Bioinformatics Institute.<\/p>\n

\u00bb Link to the news:<\/strong> CNAG website [+]<\/a>
\n\u00bb Reference article:<\/strong>\u00a0Mc Cartney, A.M., Formenti, G., Mouton, A.\u00a0et al.<\/i>\u00a0The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics.\u00a0npj biodivers<\/i>\u00a03<\/b>, 28 (2024).\u00a0DOI:\u00a0<\/span>10.1038\/s44185-024-00054-6<\/span><\/a><\/p>\n

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The\u00a0European Reference Genome Atlas (ERGA) Pilot Project unites more than 200 researchers from across Europe to produce reference genomes for 98 species, establishing the basis for generating high-quality DNA maps…<\/p>\n","protected":false},"author":14,"featured_media":89083,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-98383","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"acf":[],"yoast_head":"\nDNA maps to stop biodiversity loss - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/dna-maps-to-stop-biodiversity-loss\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DNA maps to stop biodiversity loss - 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