{"id":95956,"date":"2024-05-28T13:06:06","date_gmt":"2024-05-28T11:06:06","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/"},"modified":"2024-05-29T10:18:57","modified_gmt":"2024-05-29T08:18:57","slug":"3d-bioprinting-for-an-advanced-gut-on-chip-model","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/","title":{"rendered":"3D bioprinting for an advanced gut-on-chip model"},"content":{"rendered":"<p><strong>A team from the Institute for Bioengineering of Catalonia (<a href=\"https:\/\/www.pcb.ub.edu\/en\/empresa\/institut-de-bioenginyeria-de-catalunya-ibec\/\" target=\"_blank\" rel=\"noopener\">IBEC<\/a>), in collaboration with the Institute of Microelectronics of Barcelona (<a href=\"https:\/\/www.imb-cnm.csic.es\/en\" target=\"_blank\" rel=\"noopener\">IMB-CNM<\/a>), has developed an advanced model of gut-on-chip, that contains a 3D bioprinted channel with structures that mimic the intestinal villi and reproduces the epithelial and stromal compartments of the intestinal mucosa. \u00a0Electrodes have been incorporated into this model to monitor the formation of the intestinal barrier in real time. The device is highly versatile and has potential applications in disease modelling and drug screening.<\/strong><\/p>\n<p>In the field of organ-on-chip, conventional gut-on-chip models have struggled to reproduce the complexity of the human gut, particularly in fully representing its essential components. The gut is composed of several layers, including the epithelium, which forms the inner surface, and the stroma, a connective tissue that supports the epithelium and maintains the integrity of the intestinal barrier. The lack of adequate representation of these components has limited the development of effective models. However, new technologies such as 3D bioprinting and the use of hydrogels as extracellular matrix analogs are opening up new possibilities in the field of organ-on-chip.<\/p>\n<p>The\u00a0<a href=\"https:\/\/ibecbarcelona.eu\/es\/biomsyscelleng\" target=\"_blank\" rel=\"noopener\">Biomimetic Systems for Cell Engineering group<\/a> at IBEC, in collaboration with the <a href=\"https:\/\/www.imb-cnm.csic.es\/en\/research\/research-groups\/biomedical-applications-group-gab\" target=\"_blank\" rel=\"noopener\">Biomedical Applications Group (GAB)<\/a>\u00a0of IMB-CNM, has developed an advanced model of gut-on-chip. It is an innovative device that contains a 3D bioprinted channel with structures that mimic the intestinal villi and reproduces the epithelial and stromal compartments of the intestinal mucosa. Electrodes have been incorporated into this model to monitor the formation of the intestinal barrier in real time. The device is highly versatile and has potential applications in disease modelling and drug screening.<\/p>\n<p>\u201cIn our study, we integrate the soft part, made of hydrogels with cells, with a suitable morphology. The most innovative thing is that we do this by combining bioprinting directly on the fluidic chip,\u201d explains <strong>Elena Mart\u00ednez Fraiz<\/strong>, IBEC Senior Researcher, Associate Professor at the University of Barcelona (UB) and leader of the study.<\/p>\n<p>The team is already working on making the system even more complex: \u201cOur goal is to be able to simulate conditions that are closer to reality and, in the near future, to develop a model to study, for example, inflammatory bowel disease or disorders related to bacterial overpopulation,\u201d says <strong>N\u00faria Torras Andr\u00e9s<\/strong>, senior researcher in Mart\u00ednez\u2019s group and author of the study.<\/p>\n<p>\u201cThe long-term goal is to obtain models that are more realistic and closer to human physiology, in order to replace animal experiments and make medicine much more personalised,\u201d explains <strong>Mar\u00eda Garc\u00eda D\u00edaz<\/strong>, senior researcher in Mart\u00ednez\u2019s group and author of the study.<\/p>\n<p><strong>\u00bb Reference article:<\/strong>\u00a0Daniel Vera, Mar\u00eda Garc\u00eda-D\u00edaz, N\u00faria Torras, \u00d3scar Castillo, Xavi Illa, Rosa Villa, Mar Alvarez and Elena Martinez. A 3D bioprinted hydrogel gut-on-chip with integrated electrodes for transepithelial electrical resistance (TEER) measurements&#8221;.\u00a0<em>Biofabrication<\/em> (2024). DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1088\/1758-5090\/ad3aa4\" target=\"_blank\" rel=\"noopener\">10.1088\/1758-5090\/ad3aa4<\/a><\/p>\n<p><strong>\u00bb Link to the news: <\/strong><a href=\"https:\/\/ibecbarcelona.eu\/ca\/bioimpressio-3d-per-a-un-model-avancat-intesti-en-un-xip\" target=\"_blank\" rel=\"noopener\">IBEC website [+]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team from the Institute for Bioengineering of Catalonia (IBEC), in collaboration with the Institute of Microelectronics of Barcelona (IMB-CNM), has developed an advanced model of gut-on-chip, that contains a&#8230;<\/p>\n","protected":false},"author":4,"featured_media":95875,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-95956","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>3D bioprinting for an advanced gut-on-chip model - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"3D bioprinting for an advanced gut-on-chip model - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"A team from the Institute for Bioengineering of Catalonia (IBEC), in collaboration with the Institute of Microelectronics of Barcelona (IMB-CNM), has developed an advanced model of gut-on-chip, that contains a...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/\" \/>\n<meta property=\"og:site_name\" content=\"Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"article:published_time\" content=\"2024-05-28T11:06:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-29T08:18:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2024\/05\/IBEC_NTorras_DEF-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1172\" \/>\n\t<meta property=\"og:image:height\" content=\"479\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Azucena Berea\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Azucena Berea\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/\"},\"author\":{\"name\":\"Azucena Berea\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/810a86a39effe6bf90f9ab918ca43239\"},\"headline\":\"3D bioprinting for an advanced gut-on-chip model\",\"datePublished\":\"2024-05-28T11:06:06+00:00\",\"dateModified\":\"2024-05-29T08:18:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/\"},\"wordCount\":494,\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/IBEC_NTorras_DEF-1.png\",\"articleSection\":[\"SCIENCE\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/\",\"name\":\"3D bioprinting for an advanced gut-on-chip model - Parc Cient\u00edfic de Barcelona\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/IBEC_NTorras_DEF-1.png\",\"datePublished\":\"2024-05-28T11:06:06+00:00\",\"dateModified\":\"2024-05-29T08:18:57+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/810a86a39effe6bf90f9ab918ca43239\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/IBEC_NTorras_DEF-1.png\",\"contentUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/IBEC_NTorras_DEF-1.png\",\"width\":1172,\"height\":479},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/3d-bioprinting-for-an-advanced-gut-on-chip-model\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"3D bioprinting for an advanced gut-on-chip model\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#website\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/\",\"name\":\"Parc Cient\u00edfic de Barcelona\",\"description\":\"Universitat de Barcelona\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/810a86a39effe6bf90f9ab918ca43239\",\"name\":\"Azucena Berea\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/32577545a82a87a5c7e06fb02f02362edb2f379afdb4c8b5783d81635141181f?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/32577545a82a87a5c7e06fb02f02362edb2f379afdb4c8b5783d81635141181f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/32577545a82a87a5c7e06fb02f02362edb2f379afdb4c8b5783d81635141181f?s=96&d=mm&r=g\",\"caption\":\"Azucena Berea\"},\"sameAs\":[\"https:\\\/\\\/www.pcb.ub.edu\"],\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/author\\\/aberea\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"3D bioprinting for an advanced gut-on-chip model - Parc Cient\u00edfic de Barcelona","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/","og_locale":"en_US","og_type":"article","og_title":"3D bioprinting for an advanced gut-on-chip model - Parc Cient\u00edfic de Barcelona","og_description":"A team from the Institute for Bioengineering of Catalonia (IBEC), in collaboration with the Institute of Microelectronics of Barcelona (IMB-CNM), has developed an advanced model of gut-on-chip, that contains a...","og_url":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/","og_site_name":"Parc Cient\u00edfic de Barcelona","article_published_time":"2024-05-28T11:06:06+00:00","article_modified_time":"2024-05-29T08:18:57+00:00","og_image":[{"width":1172,"height":479,"url":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2024\/05\/IBEC_NTorras_DEF-1.png","type":"image\/png"}],"author":"Azucena Berea","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Azucena Berea","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/#article","isPartOf":{"@id":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/"},"author":{"name":"Azucena Berea","@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/810a86a39effe6bf90f9ab918ca43239"},"headline":"3D bioprinting for an advanced gut-on-chip model","datePublished":"2024-05-28T11:06:06+00:00","dateModified":"2024-05-29T08:18:57+00:00","mainEntityOfPage":{"@id":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/"},"wordCount":494,"image":{"@id":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/#primaryimage"},"thumbnailUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2024\/05\/IBEC_NTorras_DEF-1.png","articleSection":["SCIENCE"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/","url":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/","name":"3D bioprinting for an advanced gut-on-chip model - Parc Cient\u00edfic de Barcelona","isPartOf":{"@id":"https:\/\/www.pcb.ub.edu\/es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/#primaryimage"},"image":{"@id":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/#primaryimage"},"thumbnailUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2024\/05\/IBEC_NTorras_DEF-1.png","datePublished":"2024-05-28T11:06:06+00:00","dateModified":"2024-05-29T08:18:57+00:00","author":{"@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/810a86a39effe6bf90f9ab918ca43239"},"breadcrumb":{"@id":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/#primaryimage","url":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2024\/05\/IBEC_NTorras_DEF-1.png","contentUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2024\/05\/IBEC_NTorras_DEF-1.png","width":1172,"height":479},{"@type":"BreadcrumbList","@id":"https:\/\/www.pcb.ub.edu\/en\/3d-bioprinting-for-an-advanced-gut-on-chip-model\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.pcb.ub.edu\/en\/"},{"@type":"ListItem","position":2,"name":"3D bioprinting for an advanced gut-on-chip model"}]},{"@type":"WebSite","@id":"https:\/\/www.pcb.ub.edu\/es\/#website","url":"https:\/\/www.pcb.ub.edu\/es\/","name":"Parc Cient\u00edfic de Barcelona","description":"Universitat de Barcelona","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pcb.ub.edu\/es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/810a86a39effe6bf90f9ab918ca43239","name":"Azucena Berea","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/32577545a82a87a5c7e06fb02f02362edb2f379afdb4c8b5783d81635141181f?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/32577545a82a87a5c7e06fb02f02362edb2f379afdb4c8b5783d81635141181f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/32577545a82a87a5c7e06fb02f02362edb2f379afdb4c8b5783d81635141181f?s=96&d=mm&r=g","caption":"Azucena Berea"},"sameAs":["https:\/\/www.pcb.ub.edu"],"url":"https:\/\/www.pcb.ub.edu\/en\/author\/aberea\/"}]}},"_links":{"self":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts\/95956","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/comments?post=95956"}],"version-history":[{"count":1,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts\/95956\/revisions"}],"predecessor-version":[{"id":95958,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts\/95956\/revisions\/95958"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/media\/95875"}],"wp:attachment":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/media?parent=95956"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/categories?post=95956"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/tags?post=95956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}