{"id":95172,"date":"2024-05-03T14:49:06","date_gmt":"2024-05-03T12:49:06","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/synchronisation-between-the-central-circadian-clock-and-the-circadian-clocks-of-tissues-preserves-their-functioning-and-prevents-ageing\/"},"modified":"2024-05-16T16:36:28","modified_gmt":"2024-05-16T14:36:28","slug":"synchronisation-between-the-central-circadian-clock-and-the-circadian-clocks-of-tissues-preserves-their-functioning-and-prevents-ageing","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/synchronisation-between-the-central-circadian-clock-and-the-circadian-clocks-of-tissues-preserves-their-functioning-and-prevents-ageing\/","title":{"rendered":"Synchronisation between the central circadian clock and the circadian clocks of tissues preserves their functioning and prevents ageing"},"content":{"rendered":"<p><strong>Two complementary research articles, published simultaneously in the journals\u00a0Science\u00a0and\u00a0Cell Stem Cell\u00a0by a team of scientists from <a href=\"https:\/\/www.pcb.ub.edu\/en\/empresa\/institut-de-recerca-biomedica-irb-barcelona\/\" target=\"_blank\" rel=\"noopener\">IRB Barcelona<\/a>, based in the Barcelona Science Park, and UPF reveal that central and peripheral circadian clocks coordinate to regulate the daily activity of skin and muscles. This synchronisation\u00a0 prevents premature muscle ageing and improves muscle function, suggesting new strategies to tackle age-related decline through circadian rhythm modulation.<\/strong><\/p>\n<p>Discovered in the 1970s, circadian clocks are essential for the regulation of biological time in most cells in the human body. These internal mechanisms adjust biological processes to a 24-hour cycle, allowing the synchronisation of cellular functions with daily variations in the environment. Circadian rhythms, which are coordinated by a central clock in the brain that communicates with clocks in different peripheral tissues, influence many functions, from our sleep patterns to our ability to metabolise food.<\/p>\n<p>A team led by\u00a0<strong>Dr. Salvador Aznar Benitah<\/strong>, an ICREA researcher at IRB Barcelona, and\u00a0<strong>Dr. Pura Mu\u00f1oz-C\u00e1noves<\/strong>, an ICREA researcher in the Department of Medicine and Life Sciences at the Pompeu Fabra University (UPF), has described how the synchronisation between the central clock and peripheral clocks in muscle and skin plays a key role in ensuring the correct function of these tissues, as well as preventing degenerative processes associated with ageing.<\/p>\n<p>The results of this work have been published in two articles in high-impact journals. In this regard, the research on the synchronisation between the central and peripheral clocks appears in\u00a0Science, while the work on the coordination between the central clock and skin peripheral clock has been released in\u00a0Cell Stem Cell. Both studies reveal the common mechanisms that underscore the importance of this coordination to uphold the optimal functionality of muscle and skin.<\/p>\n<p>The work also describes the remarkable degree of autonomy of the peripheral clocks, which can maintain 24-h cycles and manage approximately 15% of circadian functions in the absence of the central clock.<\/p>\n<p>\u201cIt is fascinating to see how synchronisation between the brain and peripheral circadian clocks plays a critical role in skin and muscle health, while peripheral clocks alone are autonomous in carrying out the most basic tissue functions,\u201d says <strong>Dr. Aznar Benitah<\/strong>, head of the\u00a0<a href=\"https:\/\/www.irbbarcelona.org\/en\/research\/stem-cells-and-cancer\" target=\"_blank\" rel=\"noopener\">Stem Cell and Cancer laboratory<\/a>\u00a0at IRB Barcelona.<\/p>\n<p>\u201cOur study reveals that minimal interaction between only two tissue clocks (one central and the other peripheral) is needed to maintain optimal functioning of tissues like muscles and skin and to avoid their deterioration and ageing. Now, the next step is to identify the signalling factors involved in this interaction, with potential therapeutic applications in mind,\u201d explains\u00a0<strong>Dr. Mu\u00f1oz-C\u00e1noves<\/strong>, a UPF professor who is now a principal investigator at Altos Labs (San Diego, US).<\/p>\n<p><strong>\u00bb For furhter information:<\/strong> <a href=\"https:\/\/www.irbbarcelona.org\/en\/news\/scientific\/synchronisation-between-central-circadian-clock-and-circadian-clocks-tissues\" target=\"_blank\" rel=\"noopener\">IRB Barcelona website [+]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Two complementary research articles, published simultaneously in the journals\u00a0Science\u00a0and\u00a0Cell Stem Cell\u00a0by a team of scientists from IRB Barcelona, based in the Barcelona Science Park, and UPF reveal that central and&#8230;<\/p>\n","protected":false},"author":14,"featured_media":95165,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-95172","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - 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