{"id":94153,"date":"2024-03-26T10:21:17","date_gmt":"2024-03-26T09:21:17","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/a-team-from-ibec-mimics-the-complex-neuroblastoma-vasculature-on-a-chip-to-explore-treatments-for-this-pediatric-cancer\/"},"modified":"2024-03-26T14:00:14","modified_gmt":"2024-03-26T13:00:14","slug":"a-study-mimics-the-complex-neuroblastoma-vasculature-on-a-chip-to-explore-treatments-for-this-pediatric-cancer","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/a-study-mimics-the-complex-neuroblastoma-vasculature-on-a-chip-to-explore-treatments-for-this-pediatric-cancer\/","title":{"rendered":"A study mimics the complex neuroblastoma vasculature on a chip to explore treatments for this pediatric cancer"},"content":{"rendered":"<p><strong>Two works led by the <a href=\"https:\/\/www.pcb.ub.edu\/en\/empresa\/institut-de-bioenginyeria-de-catalunya-ibec\/\" target=\"_blank\" rel=\"noopener\">Institute for Bioengineering of Catalonia (IBEC)<\/a>, based in the barcelona Science Park, have successfully mimicked the transdifferentiation process of the neuroblastoma vasculature in <em>in vitro<\/em> models. These models, one in 2D and the other on a microfluidic chip, provide platforms for identifying new biomarkers and designing effective therapies against this type of cancer. Dr. Ar\u00e1nzazu Villasante, \u00a0a senior researcher in the <a href=\"https:\/\/ibecbarcelona.eu\/es\/nanobioengineering\/\" target=\"_blank\" rel=\"noopener\">Nanobioengineering<\/a> group, led by Dr. Josep Samitier, is the lead author of these studies, published in the scientific journals In vitro models and Cancers, respectively.<\/strong><\/p>\n<p>Neuroblastoma, one of the most common childhood cancers, is classified as a developmental cancer because it arises prenatally during the formation of organs and tissues. It originates from cancer cells that develop in neuroblasts, a type of immature nerve tissue, and primarily affects the adrenal glands.<\/p>\n<p>One of the research focal points of \u00a0<strong>Dr. Josep Samitier<\/strong>\u2019s <a href=\"https:\/\/ibecbarcelona.eu\/es\/nanobioengineering\/\">Nanobioengineering <\/a>group, led by <strong>Dr. Ar\u00e1nzazu Villasante<\/strong>, is the creation of in vitro neuroblastoma models that replicate its characteristic vasculature in order to search for new biomarkers and develop effective therapies against this type of cancer.<\/p>\n<p>This is important because a hallmark of neuroblastoma is its increased vascularisation, which can be mediated by a process known as transdifferentiation, in which cancer cells transform into endothelial cells that form the tumour\u2019s blood vessels. This process has been linked to treatment resistance and cancer recurrence.<\/p>\n<p><strong>Dr. Villasante<\/strong>, a senior researcher in the group, is the lead author of two recent studies on this topic, published in the scientific journals \u00a0In vitro models (DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s44164-023-00064-x\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1007\/s44164-023-00064-x<\/a>) and Cancers ( DOI: <a href=\"https:\/\/doi.org\/10.3390\/cancers16051060\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/cancers16051060<\/a>), respectively. These studies describe on how the research team was able to replicate the transdifferentiation process of the neuroblastoma vasculature in\u00a0<em>in vitro<\/em>\u00a0models. They achieved this in two easily reproducible systems: a simpler 2D model used to explore potential therapeutic targets, and a more complex microfluidic chip designed for drug screening. Additionally, they have identified the biomarker GB3 as a potential therapeutic target for future nanotherapies against neuroblastoma.<\/p>\n<p><strong>\u00bb For further information:<\/strong> <a href=\"https:\/\/ibecbarcelona.eu\/a-study-led-by-ibec-successfully-mimics-the-complex-neuroblastoma-vasculature-on-a-chip-to-explore-treatments-for-this-pediatric-cancer\/\" target=\"_blank\" rel=\"noopener\">IBEC website [+]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Two works led by the Institute for Bioengineering of Catalonia (IBEC), based in the barcelona Science Park, have successfully mimicked the transdifferentiation process of the neuroblastoma vasculature in in vitro&#8230;<\/p>\n","protected":false},"author":14,"featured_media":94143,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-94153","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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