{"id":90316,"date":"2023-11-23T12:01:55","date_gmt":"2023-11-23T11:01:55","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/vitamin-b12-a-key-player-in-cellular-reprogramming-and-tissue-regeneration\/"},"modified":"2023-11-20T15:04:31","modified_gmt":"2023-11-20T14:04:31","slug":"vitamin-b12-a-key-player-in-cellular-reprogramming-and-tissue-regeneration","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/vitamin-b12-a-key-player-in-cellular-reprogramming-and-tissue-regeneration\/","title":{"rendered":"Vitamin B12: a key player in cellular reprogramming and tissue regeneration"},"content":{"rendered":"<p><strong>Researchers at <a href=\"https:\/\/www.pcb.ub.edu\/en\/empresa\/institut-de-recerca-biomedica-irb-barcelona\/\" target=\"_blank\" rel=\"noopener\">IRB Barcelona<\/a> reveal that vitamin B12 significantly boosts the efficiency of cellular reprogramming, thus holding promise for regenerative medicine. The team validated their findings in a model of ulcerative colitis, demonstrating its potential in speeding up tissue repair in a model of ulcerative colitis\u2014an observation that points to potential new treatments for inflammatory diseases. The discovery has been published in the journal\u00a0<em>Nature Metabolism<\/em>.<\/strong><\/p>\n<p>Vitamin B12 is a well-known micronutrient that has long been acknowledged for its essential role in maintaining nerve function, supporting red blood cell production, and facilitating DNA synthesis, all vital processes for overall health. Researchers led by\u00a0<strong>Dr. Manuel Serrano<\/strong> at IRB Barcelona have now revealed that vitamin B12 also plays a pivotal role in cellular reprogramming and tissue regeneration.<\/p>\n<p>The research was focused on an experimental process known as cellular reprogramming which is thought to mimic the early phases to tissue repair. The IRB Barcelona team found that cellular reprogramming in mice consumes large amounts of\u00a0vitamin B12. Indeed, the depletion of vitamin B12 becomes a limiting factor that delays and impairs some aspects of the reprogramming process. Considering the abundance of vitamin B12 in the normal diet of mice, the investigators were surprised to observe that the simple supplementation of vitamin B12 significantly enhanced the efficiency of reprogramming.<\/p>\n<h3><strong>Therapeutic potential in ulcerative colitis<\/strong><\/h3>\n<p>The researchers validated their findings in a model of ulcerative colitis, demonstrating that the intestinal cells initiating repair undergo a process similar to cellular reprogramming and also benefit from vitamin B12 supplementation. Patients with intestinal bowel disease could potentially benefit from vitamin B12 supplementation.<\/p>\n<p>\u201cOur research uncovers a critical role of vitamin B12 in cellular reprogramming and tissue repair. These findings hold promise for regenerative medicine, with the potential to benefit patients through an improved nutrition,&#8221; says <strong>Dr. Manuel Serrano.<\/strong><\/p>\n<h3><strong>Understanding the role of vitamin B12 in cellular reprogramming<\/strong><\/h3>\n<p>In this study, the researchers delved into the metabolic requirements of cellular reprogramming and found that vitamin B12 is a limiting factor for a particular branch of metabolism involved in a reaction known as methylation. Precisely, the DNA of the cells initiating reprogramming or tissue repair require very high levels of this methylation reaction and therefore of vitamin B12. The researchers discovered that vitamin B12 insufficiency during reprogramming or tissue repair resulted in significant epigenetic changes, leading to errors in the function of multiple genes.<\/p>\n<div style=\"width: 735px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2023\/11\/F_EUJz0XYAAsIFg-e1700479917385.jpg\" alt=\"\" width=\"725\" height=\"460\" \/><p class=\"wp-caption-text\">Dr. Marta Kovatcheva. Image \/ IRB Barcelona.<\/p><\/div>\n<p>\u201cSupplementation with vitamin B12 corrected this imbalance, resulting in enhanced gene function fidelity and overall improved reprogramming efficiency,\u201d confirms <strong>Dr. Marta Kovatcheva<\/strong>, first author of the study and a postdoctoral researcher in the same laboratory.<\/p>\n<h3><strong>Separate study links vitamin B12 to lower inflammation<\/strong><\/h3>\n<p>The group led by Dr. Serrano has\u00a0<a class=\"elf-external elf-icon\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.12976\" target=\"_blank\" rel=\"nofollow noopener\">recently published another study<\/a>, in collaboration with the laboratory of\u00a0<strong>Dr. Rosa Lamuela-Ravent\u00f3s<\/strong>\u00a0at the University of Barcelona (UB), and\u00a0<strong>Dr. Ramon Estruch\u00a0<\/strong>at the Hospital Cl\u00ednic of Barcelona, in which they concluded that people with higher levels of vitamin B12 in blood had lower levels of inflammatory markers (IL-6 and CRP).\u00a0 The researchers also observed a similar relationship in aged mice. These observations suggest that vitamin B12 exerts anti-inflammatory action by reducing these markers in the body and they provide valuable insights into the potential health benefits of vitamin B12.<\/p>\n<p>The research was conducted in collaboration with the groups of\u00a0<strong>Dr. Guido Kroemer<\/strong>\u00a0at the Institut Gustave Roussy (in France), the laboratory led by\u00a0<strong>Dr. \u00d3scar Yanes<\/strong>\u00a0at the Universitat Rovira i Virgili (Spain), IRB Barcelona&#8217;s Bioinformatics and Biostatistics Core Facility, led by\u00a0<strong>Dr. Camille Stephan-Otto Attolini<\/strong>\u00a0and the Histopathology Core Facility, led by\u00a0<strong>Dr. Neus Prats<\/strong>, both at IRB Barcelona and the University of Barcelona. <strong>Dr. Manuel Serrano<\/strong>\u00a0is presently working at Altos Labs, Cambridge, UK.<\/p>\n<p>The project has received funding from the following agencies: the Barcelona Institute of Science and Technology (BIST); the Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC); the European Molecular Biology Organization (EMBO); the Karolinska Institute, the Swedish Research Council; the Ligue contre le Cancer; the Agence National de la Recherche (ANR); the Association pour la recherche sur le cancer (ARC); the Fondation pour la Recherche M\u00e9dicale (FRM); the European Joint Programme on Rare Diseases (EJPRD); the European Research Council (ERC); the Institut National du Cancer (INCa); the Institut Universitaire de France; the Mark Foundation;\u00a0 the Seerave Foundation; &#8220;la Caixa&#8221; Foundation; the Milky Way Research Foundation; the Spanish Ministry of Science, the European Regional Development Fund (ERDF); and the Secretaria d&#8217;Universitats i Recerca del Departament d&#8217;Empresa i Coneixement of Catalonia.<\/p>\n<p><strong>\u00bb Reference article<\/strong>: Marta Kovatcheva, Elena Melendez, Dafni Chondronasiou, Federico Pietrocola, Raquel Bernad, Adri\u00e0 Caballe, Alexandra Junza, Jordi Capellades, Adri\u00e1n Holgu\u00edn-Horcajo, Neus Prats, Sylvere Durand, Meritxell Rovira, Oscar Yanes, Camille Stephan-Otto Attolini, Guido Kroemer &amp; Manuel Serrano. Vitamin B<sub>12<\/sub>\u00a0is a limiting factor for induced cellular plasticity and tissue repair.\u00a0<i>Nat Metab<\/i>\u00a0(2023).\u00a0DOI: \u00a0<a class=\"elf-external elf-icon\" href=\"https:\/\/www.nature.com\/articles\/s42255-023-00916-6\" target=\"_blank\" rel=\"noopener nofollow\">10.1038\/s42255-023-00916-6<\/a><\/p>\n<p><strong>\u00bb Lint to the news: <a href=\"https:\/\/www.irbbarcelona.org\/en\/news\/scientific\/vitamin-b12-key-player-cellular-reprogramming-and-tissue-regeneration\" target=\"_blank\" rel=\"noopener\">IRB Barcelona website [+]<\/a><\/strong><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at IRB Barcelona reveal that vitamin B12 significantly boosts the efficiency of cellular reprogramming, thus holding promise for regenerative medicine. The team validated their findings in a model of&#8230;<\/p>\n","protected":false},"author":14,"featured_media":90308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-90316","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Vitamin B12: a key player in cellular reprogramming and tissue regeneration - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/vitamin-b12-a-key-player-in-cellular-reprogramming-and-tissue-regeneration\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vitamin B12: a key player in cellular reprogramming and tissue regeneration - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Researchers at IRB Barcelona reveal that vitamin B12 significantly boosts the efficiency of cellular reprogramming, thus holding promise for regenerative medicine. 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