{"id":85633,"date":"2023-06-20T09:21:09","date_gmt":"2023-06-20T07:21:09","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/?p=85633"},"modified":"2023-09-12T15:05:53","modified_gmt":"2023-09-12T13:05:53","slug":"first-baby-born-as-a-result-of-a-new-reproduction-technique-that-activates-sperm","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/first-baby-born-as-a-result-of-a-new-reproduction-technique-that-activates-sperm\/","title":{"rendered":"First baby born as a result of a new reproduction technique that activates sperm"},"content":{"rendered":"

Fecundis<\/a>, a med-tech start-up based in Barcelona\u2019s Science Park, has developed a new assisted-reproduction technique that activates sperm and which has now successfully completed its first clinical trial with the birth of a newborn.<\/strong><\/p>\n

According to the WHO, 1 in 6 couples will face infertility in their lifetime and will need medical assistance to conceive. However, only 1 of every 3 assisted-reproduction treatments results in a birth of a child. To improve these outcomes, the focus has historically been on the female gamete, the oocyte. However, it has been discovered that the semen contributes beyond fertilization, and that it\u2019s activity is key for the correct development of embryos and consequently the success of treatments.<\/p>\n

A new assisted-reproduction technique that activates sperm has now successfully completed its first clinical trial with the birth of a baby to parents with a long history of infertility. The new technique was developed by Fecundis, a med-tech start-up based in Barcelona\u2019s Science Park, and the baby was born in Argentina after treatment at the In Vitro Buenos Aires Clinic, a partner in the research along with CONICET and the Universidad Nacional de Rosario. Another two pregnancies achieved with the same technique are currently in their third trimester.<\/p>\n

A technique that focuses on sperm<\/strong><\/h3>\n

The sperm activation technique developed by Fecundis, called HyperSperm, reproduces in the sperm the same biochemical changes that are naturally produced in the female reproductive system during fertilization. These changes allow the sperm to acquire a movement pattern called hyperactivation, which is critical to the success of fertilization but which is not correctly reproduced with current assisted-reproduction techniques.<\/p>\n

\u201cIn assisted-reproduction clinics, in general, little attention is paid to sperm and we lack standardized protocols for handling semen,\u201d explains the international expert in reproductive medicine Rita Vassena<\/strong>, CEO of Fecundis. \u201cWe are gaining more and more understanding of the sperm role beyond fertilization and its effects on the development of embryos and even the overall success of pregnancies. We have developed our treatment with this new focus on the male gamete in order to maximize the success of treatments for all patients.\u201d Vassena emphasizes that the results of the study \u201care encouraging, as they would mean that the time and cost of assisted-reproduction treatments could be cut in half.\u201d<\/p>\n

For years, the sperm was considered a mere vessel for the father\u2019s genetic contribution to the embryo. \u201cWe now know that the functions of the sperm go far beyond simply providing the paternal genetic material to the embryo,\u201d explains Dario Krapf<\/strong>, an international expert in sperm biology and Head of R+D+i at Fecundis. \u201cThe molecular processes that take place after ejaculation (called capacitation) has a crucial effect on the correct development of the embryo. The technology developed by Fecundis recreates in the laboratory the natural changes that a sperm cell undergoes in the female tract, enabling a highly efficient assisted reproductive procedure.\u201d<\/p>\n

A pioneering clinical study<\/strong><\/h3>\n

To test the viability of the technique for fertility treatments, Fecundis launched a pilot trial in Argentina, where it carries out part of its activity, in 2022. 10 infertile couples with a long history of unsuccessful in vitro fertilizations (IVF) treatment were selected as they started a new treatment using donor eggs. To analyze the results of the study, each couple\u2019s eggs were divided into two groups: half of them were fertilized according to the standard of care while the other half were fertilized after treating the semen with HyperSperm.<\/p>\n

To assess the effectiveness of the treatment, the usual IVF success parameters were analyzed, especially with regard to fertilization and embryo development. The sperm treated with HyperSperm generated 63% more high-quality embryos compated to the control group. Some patients also received embryo transfers derived from the HyperSperm treatment that have resulted in pregnancies: one has given birth to a baby, while two others are in their third trimester.<\/p>\n

The data obtained at the end of this study are encouraging and suggest that HyperSperm could cut the time to achieve a pregnancy through assisted reproduction by half, making the process cheaper and accessible to more patients. However, the researchers reiterated that this is a pilot study and, as such, is limited in size and scope. A definitive assessment of the clinical value of the technique in larger trials is already underway.<\/p>\n","protected":false},"excerpt":{"rendered":"

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