{"id":85330,"date":"2023-05-31T11:03:37","date_gmt":"2023-05-31T09:03:37","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/?p=85330"},"modified":"2023-06-01T10:22:02","modified_gmt":"2023-06-01T08:22:02","slug":"revealed-cellular-conversations-that-initiate-pancreatic-cancer","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/","title":{"rendered":"Cell-to-Cell signaling plays crucial role in early pancreatic cancer progression, study in mice reveals"},"content":{"rendered":"

Scientists from IRB Barcelona<\/a>, located at the Barcelona Science Park, and Memorial Sloan Kettering Cancer Center in New York, have published in Science a high-resolution epigenetic map of how cells with a mutation in the KRAS gene acquire plasticity and drive cancer progression when exposed to inflammation. The study, conducted in mice, paves the way for new therapeutic approaches.<\/strong><\/p>\n

Genetic mutations are frequent and known causes of cancer, but they cannot explain the entire development of the disease. The new study published in Science shows that interactions between these mutations and external factors, such as tissue damage, can modify the identity and local environment of cells, promoting the emergence and progression of tumors.<\/p>\n

In pancreatic cancer, these changes begin to occur between 24 and 48 hours after tissue damage; as a result, some cells with the oncogene KRAS mutation acquire the ability to send and receive many more signals than a normal cell, engaging in these “conversations” in a structured manner.<\/p>\n

“This work has been made possible thanks to a synergy between experimental and computational science,” highlights Dr. Alonso-Curbelo<\/strong> from IRB Barcelona, who co-led the study along with researchers from Memorial Sloan Kettering Cancer Center in New York.<\/p>\n

In this regard, the researchers’ computational predictions have been validated with various experimental techniques, such as imaging techniques that have shown the proximity of cell populations communicating with each other within the tissue. The researchers have been able to demonstrate that these conversations drive cancer development.<\/p>\n

Understanding how these communication networks between cells function provides a new roadmap for the development of potential therapies that can block or slow down the progression of pancreatic tumors.<\/p>\n

The study concludes a line of research initiated by Dr. Alonso-Curbelo to elucidate the mechanism by which inflammation promotes cancer initiation.<\/p>\n

\u00bb Reference article<\/strong>: Cassandra Burdziak, Direna Alonso-Curbelo, Thomas Walle, Jose\u0301 Reyes, Francisco M. Barriga, et al. “Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis”. Science (2022) DOI: 10.1126\/science.add5327<\/a><\/p>\n

\u00bb Enlla\u00e7 a la not\u00edcia:<\/strong> web de l\u2019IRB Barcelona [+]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Scientists from IRB Barcelona, located at the Barcelona Science Park, and Memorial Sloan Kettering Cancer Center in New York, have published in Science a high-resolution epigenetic map of how cells…<\/p>\n","protected":false},"author":11,"featured_media":85309,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-85330","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"acf":[],"yoast_head":"\nCell-to-Cell signaling plays crucial role in early pancreatic cancer progression, study in mice reveals - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cell-to-Cell signaling plays crucial role in early pancreatic cancer progression, study in mice reveals - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Scientists from IRB Barcelona, located at the Barcelona Science Park, and Memorial Sloan Kettering Cancer Center in New York, have published in Science a high-resolution epigenetic map of how cells...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"article:published_time\" content=\"2023-05-31T09:03:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-01T08:22:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2023\/05\/Science_AlonsoCurbelo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Iuris\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Iuris\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/\"},\"author\":{\"name\":\"Iuris\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/2cac99ef7339e3499496b54bb2e12e7d\"},\"headline\":\"Cell-to-Cell signaling plays crucial role in early pancreatic cancer progression, study in mice reveals\",\"datePublished\":\"2023-05-31T09:03:37+00:00\",\"dateModified\":\"2023-06-01T08:22:02+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/\"},\"wordCount\":345,\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/Science_AlonsoCurbelo.jpg\",\"articleSection\":[\"SCIENCE\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/\",\"name\":\"Cell-to-Cell signaling plays crucial role in early pancreatic cancer progression, study in mice reveals - Parc Cient\u00edfic de Barcelona\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/Science_AlonsoCurbelo.jpg\",\"datePublished\":\"2023-05-31T09:03:37+00:00\",\"dateModified\":\"2023-06-01T08:22:02+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/2cac99ef7339e3499496b54bb2e12e7d\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/Science_AlonsoCurbelo.jpg\",\"contentUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/Science_AlonsoCurbelo.jpg\",\"width\":1920,\"height\":1080},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cell-to-Cell signaling plays crucial role in early pancreatic cancer progression, study in mice reveals\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#website\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/\",\"name\":\"Parc Cient\u00edfic de Barcelona\",\"description\":\"Universitat de Barcelona\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/2cac99ef7339e3499496b54bb2e12e7d\",\"name\":\"Iuris\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a9d1bfedf501cbd8ae27b11de9986604bf4cdcea73b507457dfd4ff5dc770b75?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a9d1bfedf501cbd8ae27b11de9986604bf4cdcea73b507457dfd4ff5dc770b75?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a9d1bfedf501cbd8ae27b11de9986604bf4cdcea73b507457dfd4ff5dc770b75?s=96&d=mm&r=g\",\"caption\":\"Iuris\"},\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/author\\\/adminiuris\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cell-to-Cell signaling plays crucial role in early pancreatic cancer progression, study in mice reveals - Parc Cient\u00edfic de Barcelona","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/","og_locale":"en_US","og_type":"article","og_title":"Cell-to-Cell signaling plays crucial role in early pancreatic cancer progression, study in mice reveals - Parc Cient\u00edfic de Barcelona","og_description":"Scientists from IRB Barcelona, located at the Barcelona Science Park, and Memorial Sloan Kettering Cancer Center in New York, have published in Science a high-resolution epigenetic map of how cells...","og_url":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/","og_site_name":"Parc Cient\u00edfic de Barcelona","article_published_time":"2023-05-31T09:03:37+00:00","article_modified_time":"2023-06-01T08:22:02+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2023\/05\/Science_AlonsoCurbelo.jpg","type":"image\/jpeg"}],"author":"Iuris","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Iuris","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/#article","isPartOf":{"@id":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/"},"author":{"name":"Iuris","@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/2cac99ef7339e3499496b54bb2e12e7d"},"headline":"Cell-to-Cell signaling plays crucial role in early pancreatic cancer progression, study in mice reveals","datePublished":"2023-05-31T09:03:37+00:00","dateModified":"2023-06-01T08:22:02+00:00","mainEntityOfPage":{"@id":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/"},"wordCount":345,"image":{"@id":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2023\/05\/Science_AlonsoCurbelo.jpg","articleSection":["SCIENCE"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/","url":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/","name":"Cell-to-Cell signaling plays crucial role in early pancreatic cancer progression, study in mice reveals - Parc Cient\u00edfic de Barcelona","isPartOf":{"@id":"https:\/\/www.pcb.ub.edu\/es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/#primaryimage"},"image":{"@id":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2023\/05\/Science_AlonsoCurbelo.jpg","datePublished":"2023-05-31T09:03:37+00:00","dateModified":"2023-06-01T08:22:02+00:00","author":{"@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/2cac99ef7339e3499496b54bb2e12e7d"},"breadcrumb":{"@id":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/#primaryimage","url":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2023\/05\/Science_AlonsoCurbelo.jpg","contentUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2023\/05\/Science_AlonsoCurbelo.jpg","width":1920,"height":1080},{"@type":"BreadcrumbList","@id":"https:\/\/www.pcb.ub.edu\/en\/revealed-cellular-conversations-that-initiate-pancreatic-cancer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.pcb.ub.edu\/en\/"},{"@type":"ListItem","position":2,"name":"Cell-to-Cell signaling plays crucial role in early pancreatic cancer progression, study in mice reveals"}]},{"@type":"WebSite","@id":"https:\/\/www.pcb.ub.edu\/es\/#website","url":"https:\/\/www.pcb.ub.edu\/es\/","name":"Parc Cient\u00edfic de Barcelona","description":"Universitat de Barcelona","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pcb.ub.edu\/es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/2cac99ef7339e3499496b54bb2e12e7d","name":"Iuris","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/a9d1bfedf501cbd8ae27b11de9986604bf4cdcea73b507457dfd4ff5dc770b75?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/a9d1bfedf501cbd8ae27b11de9986604bf4cdcea73b507457dfd4ff5dc770b75?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a9d1bfedf501cbd8ae27b11de9986604bf4cdcea73b507457dfd4ff5dc770b75?s=96&d=mm&r=g","caption":"Iuris"},"url":"https:\/\/www.pcb.ub.edu\/en\/author\/adminiuris\/"}]}},"_links":{"self":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts\/85330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/comments?post=85330"}],"version-history":[{"count":3,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts\/85330\/revisions"}],"predecessor-version":[{"id":85335,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts\/85330\/revisions\/85335"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/media\/85309"}],"wp:attachment":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/media?parent=85330"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/categories?post=85330"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/tags?post=85330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}