{"id":82842,"date":"2023-03-06T12:27:32","date_gmt":"2023-03-06T11:27:32","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/innovative-strategy-against-chronic-wound-infections\/"},"modified":"2023-03-08T18:15:02","modified_gmt":"2023-03-08T17:15:02","slug":"innovative-strategy-against-chronic-wound-infections","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/innovative-strategy-against-chronic-wound-infections\/","title":{"rendered":"An innovative therapeutic strategy against chronic wound infections"},"content":{"rendered":"

A research team led by the Institute of Bioengineering of Catalonia (IBEC)<\/a>, based in the Barcelona Science Park, has published in the journal Frontiers in Microbiology a study on how the use of specific enzymes and the combination of different antibiotic drugs can mean a breakthrough in the fight against chronic wounds. The work describes the design of an innovative treatment, based on the use of optimized silver nanoparticles with enzymes and two combined antibiotics, which is highly effective against biofilms, complex structures where bacteria protect themselves from antibiotics, preventing infections from being treated effectively.<\/strong><\/p>\n

The chronicity of wounds is a relevant health problem affecting almost 2 million people in Europe. The primary cause of these wounds not healing is the presence of polymicrobial communities that form an extracellular matrix that protects them from antimicrobial agents and cells of our immune system, giving rise to a three-dimensional organization known as a biofilm.<\/p>\n

A study led by Alba Rubio Canalejas<\/strong>, an IBEC researcher, and Eduard Torrent<\/strong>s, a researcher at IBEC and the University of Barcelona, in collaboration with the Jozef Stefan Institute in Slovenia, describes the design of an innovative treatment based on the use of optimized silver nanoparticles with enzymes and two combined antibiotics, which is highly effective against biofilms. The research, published in\u00a0Frontiers in Microbiology, deals specifically with biofilms produced by dual infection of bacteria Pseudomonas aeruginosa <\/em>and Staphylococcus aureus<\/em>, two very usual microorganisms in this type of wounds.<\/p>\n

Enzymes and antibiotics combined against microbial biofilms<\/strong><\/h3>\n

Biofilms are structures formed by pathogenic bacteria and a matrix that surrounds them, made of polysaccharides, proteins, lipids, and extracellular DNA, which hinder the diffusion of antibiotics and prevent the wound from treatment.<\/p>\n

\u201cIt is necessary to investigate therapies that improve the penetrability and efficacy of antimicrobials in this situation,\u201d explains Torrents<\/strong>. \u201cSilver, for example, is known to have antimicrobial properties. We decided to use silver nanoparticles, optimized with different enzymes, to see which ones were most effective at breaking down the matrix that makes up P. aeruginosa<\/em> and S. aureus<\/em>\u201d. The researchers demonstrated that treatment with silver nanoparticles optimized with the enzyme DNAsa I reduced the multiplying capacity of P. aeruginosa<\/em> by 99.98% and that of S. aureus by 92.3% in an in vitro wound model.<\/p>\n

Once the matrix was opened, using more than one antibiotic at a time proved to be crucial in ending the infection. According to Rubio-Canalejas<\/strong>, \u201cthese two bacteria have a complex relationship in nature, where they can be competitive, due to the exoproducts produced by P. aeruginosa<\/em> that suppress the growth of S. aureus. However, in the context of biofilms, they establish synergies and collaborate. The dual infection increases their resistance and tolerance to antimicrobials, allowing them to colonize tissue and prevent wound healing.\u201d The researchers found that using a single type of drug affected each species of bacteria differently. The antibiotic ciprofloxacin caused P. aeruginosa<\/em> to outperform S. aureus, and gentamicin caused the opposite effect. However, a dual therapy that combined both compounds reduced the populations of both species.<\/p>\n

Moreover, the researchers studied the internal composition of the biofilm, representing, for the first time, a general scheme of how bacteria are distributed in three-dimensional space. \u201cWe saw that S. aureus<\/em> forms aggregates in the innermost part of the biofilm, thus protecting itself from P. aeruginosa<\/em>. This allows both to coexist and worsen any infection,\u201d explains Torrents<\/em>.<\/p>\n

\u201cThere is very little literature on how bacteria are distributed within polymicrobial biofilms.\u00a0 Figuring out how they organize themselves can go a long way toward improving future treatments\u201d, concludes.<\/p>\n

\u00bb Reference article: <\/strong>Alba Rubio-Canalejas, Aida Baelo, Sara Herbera, N\u00faria Blanco-Cabra, Marija Vukomanovic y Eduard Torrents. 3D spatial organizaci\u00f3n and improved antibiotic treatment of a\u00a0Pseudomonas aeruginosa<\/em>\u2013Staphylococcus aureus<\/em>\u00a0wound biofilm by nanoparticle enzime delivery.\u00a0 DOI:\u00a0https:\/\/doi.org\/10.3389\/fmicb.2022.959156<\/a><\/p>\n

\u00bb Link to the news: <\/strong>IBEC<\/a> website [+]\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

A research team led by the Institute of Bioengineering of Catalonia (IBEC), based in the Barcelona Science Park, has published in the journal Frontiers in Microbiology a study on how…<\/p>\n","protected":false},"author":4,"featured_media":82819,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-82842","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"acf":[],"yoast_head":"\nAn innovative therapeutic strategy against chronic wound infections - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/innovative-strategy-against-chronic-wound-infections\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"An innovative therapeutic strategy against chronic wound infections - 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