{"id":78706,"date":"2022-11-02T11:40:03","date_gmt":"2022-11-02T10:40:03","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/positive-results-from-aelix-hiv-therapeutic-vaccine-clinical-study-published-in-nature-medicine-by-vr-november-2-2022\/"},"modified":"2022-11-02T16:15:30","modified_gmt":"2022-11-02T15:15:30","slug":"positive-results-from-aelix-hiv-therapeutic-vaccine-clinical-study-published-in-nature-medicine-by-vr-november-2-2022","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/positive-results-from-aelix-hiv-therapeutic-vaccine-clinical-study-published-in-nature-medicine-by-vr-november-2-2022\/","title":{"rendered":"Positive results from Aelix\u2019 HIV therapeutic vaccine clinical study published in Nature Medicine"},"content":{"rendered":"<p><strong><a href=\"https:\/\/www.pcb.ub.edu\/en\/empresa\/aelix-therapeutics\/\" target=\"_blank\" rel=\"noopener\">Aelix Therapeutics<\/a>, a clinical-stage biotechnology company, based in the Barcelona Science park and specialized in the discovery and development of immunotherapies for HIV infection, today announces the publication in Nature Medicine of <a href=\"https:\/\/www.nature.com\/articles\/s41591-022-02060-2\" target=\"_blank\" rel=\"noopener\">the results of its Aelix-002 clinical study<\/a>\u00a0(NCT03204617).<\/strong><\/p>\n<p>\u201cWe are excited to have published the data on this important study in such a prestigious journal, reaching a wide readership. Our T-cell vaccine approach has the potential to play a critical role in strategies to cure HIV infection. Aelix is a leader in developing vaccine-based solutions for HIV cure,\u201d said <strong>Dr Christian Brander<\/strong>, co-founder and chief scientific officer at Aelix and principal investigator at IrsiCaixa.<\/p>\n<p>The Aelix-002 study was conducted in collaboration with<a href=\"https:\/\/www.gilead.com\/\" target=\"_blank\" rel=\"noopener\"> Gilead Sciences<\/a> at the <a href=\"https:\/\/www.irsicaixa.es\/en\" target=\"_blank\" rel=\"noopener\">IrsiCaixa AIDS Research Institute,<\/a> a centre jointly promoted by the \u201cla Caixa\u201d Foundation and the Department of Health of the Generalitat de Catalunya. It evaluated the safety, tolerability, immunogenicity and efficacy of Aelix\u2019 HTI T-cell therapeutic HIV vaccine (DNA.HTI, MVA.HTI and ChAdOx1.HTI) , in early treated people living with HIV. The study achieved its primary and secondary endpoints of safety, tolerability and immunogenicity.<\/p>\n<p>The trial also evaluated the efficacy of the vaccination and showed that the use of the Aelix HTI vaccine can enable a prolonged period without AntiRetroviral Therapy (ART). The strength of the vaccine-induced T-cell response significantly correlated with prolonged periods of ART. The results support the development of combination strategies based on the HTI vaccine to control HIV without the need for ongoing ART.<\/p>\n<p>\u201cThe positive results from this trial show that it is possible to induce an immune response in a person living with HIV which enables them to improve the suppression of the virus in the absence of antiretroviral medication,\u201d said <strong>Dr\u00a0Beatriz Mothe,<\/strong> principal investigator of the study at the Fight Against Infections Foundation and associate researcher at the IrsiCaixa, where the study was conducted from 2017 to 2021. \u201cA safe and effective HTI vaccine could become the backbone of combination strategies to achieve complete viral suppression, which ultimately is our common goal.\u201d<\/p>\n<p>A second clinical study, Aelix-003 (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04364035\">NCT04364035<\/a>), is being conducted in collaboration with Gilead. This active Phase 2 study is designed to evaluate the HTI vaccine in combination with Gilead\u2019s investigational Toll-Like Receptor 7 (TLR7) agonist, vesatolimod, in people with HIV on antiretroviral therapy. Vesatolimod is an immune modulator being evaluated as part of an investigational combination regimen that could potentially lead to viral remission. In this study, vesatolimod is expected to enhance the vaccine-induced immune response leading to the elimination of virus-infected cells.<\/p>\n<p>\u201cIlluminating the pathways to an HIV cure is an incredibly complex scientific challenge and collaboration is key to catalysing the research,\u201d said <strong>Devi SenGupta<\/strong>, executive director of HIV Clinical Development at Gilead Sciences. \u201cThe Aelix-003 study aims to build upon these positive results published in Nature Medicine and may help inform future directions for HIV cure research. We look forward to presenting the findings from this Phase 2 study at a future HIV congress.\u201d<\/p>\n<p>The\u00a0<a href=\"https:\/\/www.who.int\/teams\/global-hiv-hepatitis-and-stis-programmes\/hiv\/strategic-information\/hiv-data-and-statistics\" target=\"_blank\" rel=\"noopener\">HIV epidemic affects a projected 38.4 million people worldwide<\/a>, with 650,000 deaths and 1.5 million new infections in 2021. Globally, it is estimated that 28.7 million people are currently accessing antiretroviral therapy. New innovations, like Aelix\u2019 T-cell vaccine, leading to a prolonged period without ART, could be a game changer in HIV cure strategies as a combination approach to treating the disease.<\/p>\n<p><strong> \u00bb More information: <a href=\"https:\/\/www.aelixtherapeutics.com\/positive-results-from-aelix-hiv-therapeutic-vaccine-clinical-study-published-in-nature-medicine\/\" target=\"_blank\" rel=\"noopener\">Aelix website [+]<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aelix Therapeutics, a clinical-stage biotechnology company, based in the Barcelona Science park and specialized in the discovery and development of immunotherapies for HIV infection, today announces the publication in Nature&#8230;<\/p>\n","protected":false},"author":4,"featured_media":78700,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-78706","post","type-post","status-publish","format-standard","has-post-thumbnail","category-business"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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