{"id":69624,"date":"2021-12-16T15:38:20","date_gmt":"2021-12-16T14:38:20","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/immune-cell-atlas-of-human-cancers-created-for-precision-oncology\/"},"modified":"2021-12-20T09:49:14","modified_gmt":"2021-12-20T08:49:14","slug":"immune-cell-atlas-of-human-cancers-created-for-precision-oncology","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/immune-cell-atlas-of-human-cancers-created-for-precision-oncology\/","title":{"rendered":"Immune cell atlas of human cancers created for precision oncology"},"content":{"rendered":"

Researchers at the Centro Nacional de An\u00e1lisis Gen\u00f3mico (CNAG-CRG<\/a>), based in the Barcelona Science Park, have created the first cellular atlas of the immune cells infiltrating tumours. The findings, published in Genome Research, reveal that different types of tumours in the human body show surprisingly similar patterns of immune cells residing within. Scientists used this knowledge to create a classification system they believe can help predict the immunotherapy response and prognosis of cancer to a level that greatly exceeds current methods.<\/strong><\/p>\n

The researchers tested the atlas\u2019 potential through various tests, showing it can help identify the type of immune cells residing within a patient\u2019s tumour and pinpoint their location. The authors of the study believe this information make the atlas a powerful new complementary tool to personalise cancer treatments for the best possible outcome.<\/p>\n

\u201cCurrent immune-based stratification strategies often require clinicians to look individually at each tumour and visually determine its stage. This offers limited information on the prognosis of a tumour,\u201d explains\u00a0Paula Nieto<\/strong>, Computational Biotechnologist at the CNAG-CRG\u00a0and first author of the study. \u201cOur work provides much more detailed information that can help clinicians tailor treatment. While it is an important first step towards precision oncology, we need to carry out more work to test the exact clinical relevance of our proposed clusters.\u201d<\/p>\n

The researchers created the atlas by studying the tumour microenvironment. This is the collection of blood cells, immune cells and connective tissue in the immediate vicinity of a tumour, which plays a critical role in the development, progression and control of cancer.<\/p>\n

They were particularly interested in the role of immune cells in the tumour microenvironment, as it influences the effectiveness of immunotherapy, treatments that use a person\u2019s immune system to find and destroy cancer cells. Unlike conventional treatments, immunotherapy offers the possibility of long-term remission through boosting the body\u2019s natural defence systems. Despite this benefit, immunotherapy works better for some types of cancer than others and its response rate can be hard to predict.<\/p>\n

Being able to assess the types, states and location of immune cells infiltrated within a tumour, also known as its immune profile, could significantly help predict whether a patient benefits from immunotherapy. The authors of the study did this by creating the first cell atlas of immune cells from different types of cancer.<\/p>\n

They studied the gene expression of more than 500,000 individual immune cells \u2013 selecting 317,111 to analyse \u2013 from 217 patients with 13 different types of primary tumours. The analysis revealed that different types of cancer share common immune cell compositions. In total, the researchers identified six different types of immune profiles, each with its own characteristics and potentially different treatment options.<\/p>\n

The map\u2019s usefulness was tested in multiple ways. They first took gene expression data from four different types of tumours and compared it to their cell atlas. They found this could automatically assign a patient\u2019s tumour to one of the six immune profiles identified within the cell atlas.<\/p>\n

The atlas\u2019 potential to locate the coordinates of immune cells within tumours was also tested. They used a technique called SPOTlight, also developed by the CNAG-CRG, to visualise the gene expression of cells in tumour cross-sections. When combined with the atlas, this revealed the location of \u201chot\u201d and \u201ccold\u201d regions within a tumour, providing important information on which areas are likely to respond well to immunotherapy.<\/p>\n

“This cell atlas of immune cells helps us visualise tumours in ways we have never been able to before,\u201d says Holger Heyn<\/strong>, leader of the Single Cell Genomics Team at the CNAG-CRG and final author of the study. \u201cFollowing further research on patient outcome and response to treatment, we expect the atlas to be predictive for patient prognosis and immunotherapy response to a level that greatly exceeds currently applied stratification strategies.\u201d<\/p>\n

\u00bb Reference article: <\/strong>Nieto P, Elosua-Bayes M, Trincado JL, et al. \u201cA single-cell tumor immune atlas for precision oncology.\u201d Genome research vol. 31,10 (2021): 1913-1926. doi:10.1101\/gr.273300.120<\/a><\/p>\n

\u00bb For furhter information: CNAG website [+]<\/a><\/strong><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers at the Centro Nacional de An\u00e1lisis Gen\u00f3mico (CNAG-CRG), based in the Barcelona Science Park, have created the first cellular atlas of the immune cells infiltrating tumours. 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