{"id":62255,"date":"2021-04-26T13:01:58","date_gmt":"2021-04-26T11:01:58","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/first-ai-designed-drug-for-huntingtons-disease-to-enter-clinical-trials\/"},"modified":"2021-05-19T08:49:42","modified_gmt":"2021-05-19T07:49:42","slug":"first-ai-designed-drug-for-huntingtons-disease-to-enter-clinical-trials","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/first-ai-designed-drug-for-huntingtons-disease-to-enter-clinical-trials\/","title":{"rendered":"First AI-designed drug for Huntington\u2019s disease to enter clinical trials"},"content":{"rendered":"<p><strong>In less than 12 months, the collaboration between <a href=\"https:\/\/www.pcb.ub.edu\/en\/empresa\/chemotargets\/\" target=\"_blank\" rel=\"noopener noreferrer\">Chemotargets<\/a>, based in the Barcelona Science Park, and <a href=\"https:\/\/galyan-bio.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">Galyan Bio<\/a> yields a scaffold for first-in-class clinical candidates in difficult area of neurodegenerative disease.\u00a0 Chemotargets employed its proprietary AI-driven de novo drug design methods in collaboration with Gaylan Bio to rapidly design novel molecules which would bind to the previously \u2019undruggable\u2019 Huntington\u2019s Disease target.<\/strong><\/p>\n<p>Huntington\u2019s Disease (HD) is a neurodegenerative disorder that affects thousands of patients worldwide. There is currently no cure or disease modifying treatment for HD. This is why US-based company Galyan Bio and Barcelona-based Chemotargets joined efforts to design a first in class drug for HD. The result has been the generation of a first-in-class drug candidate for HD. Galyan Bio plans to start clinical trials in HD in 2022. Galyan Bio\u2019s new treatment is intended to slow down the disease in symptomatic patients and delay manifestation of HD in symptom-free gene carriers.<\/p>\n<p>\u201cThe development of new molecules through medicinal chemistry has always been a laborious and costly process. We used Chemotargets drug discovery platforms to speed up the process considerably. Based on Chemotargets\u2019 AI-driven de novo designs, we selected and tested 49 compounds. Our expectations were exceeded as we identified 6 compounds which could actually bind to our drug target. The optimization of one of those hits led to a preclinical drug candidate for HD\u201d say <strong>Dr. Simon Marius Galyan<\/strong>, CEO of Galyan Bio.<\/p>\n<p>Chemotargets\u2019 proprietary ProSurfScan AI-driven de novo drug design platform uses novel methods of agnostically scanning the target protein to perform a virtual fragment-based screening of all possible drug binding areas. Fragments are then automatically linked to design effective binding molecules. The AI-driven methods employed by Chemotargets are particularly suited to novel, difficult, previously unaddressable targets as well as drug targets for which high isoform selectivity is required. ProSurfScan is part of a complete suite of AI-driven drug discovery tools which are in routine use within Chemotargets that include CLARITY<sup>\u00ae<\/sup>, the industry-leading software platform for anticipating the safety of new drug molecules.\u00a0 <a href=\"https:\/\/www.chemotargets.com\/Chemotargets-CLARITY\" target=\"_blank\" rel=\"noopener noreferrer\">CLARITY<sup>\u00ae<\/sup><\/a> is currently in use in many of the top pharmaceutical companies worldwide and at the <a href=\"https:\/\/www.chemotargets.com\/News\/id\/40\/new-research-collaboration-agreement-(rca)-between-the-fda-cder-(center-for-drug-evaluation-and-research)-and-chemotargets-sl\" target=\"_blank\" rel=\"noopener noreferrer\">US Food and Drug Administration<\/a>.<\/p>\n<p>\u201cWe are absolutely delighted to have effectively contributed to delivering a first-in-class drug candidate for HD. Having a tangible proof-of-principle that our de novo designs lead to progressible bioactive small molecules in a prospective drug discovery project means a world to us. This means that our in-silico platform is ready to address other novel, difficult, protein targets for which no therapeutic modalities exist.\u201d said <strong>Dr. Jordi Mestres<\/strong>, CSO of Chemotargets.<\/p>\n<p>\u201cFirst and foremost, we are grateful for the opportunity to contribute to a possible therapeutic alternative for Huntington\u2019s Disease patients. I am, quite frankly, not surprised by the experimental activity results of the molecules arising from the de novo design.\u00a0 ProSurfScan has repeatedly demonstrated its ability to design novel, selective molecules which bind to novel and difficult targets in our internal programs and will no doubt continue to do so&#8221;, say <strong>Dr. Scott Boyer,<\/strong> CEO of Chemotargets.<\/p>\n<p>&#8221; Although artificial intelligence is necessary in nearly everything we do at Chemotargets, we are a company focused on helping patients. By using AI to aid decision-making in the design and development of novel therapeutics, our mission will always be to facilitate the development of safer, more effective therapeutics in less time and at a lower cost that was possible in the past.\u00a0 We are pleased that, for Huntington\u2019s Disease patients, we have been able to demonstrate that potential\u201d, he adds.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In less than 12 months, the collaboration between Chemotargets, based in the Barcelona Science Park, and Galyan Bio yields a scaffold for first-in-class clinical candidates in difficult area of neurodegenerative&#8230;<\/p>\n","protected":false},"author":14,"featured_media":62206,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-62255","post","type-post","status-publish","format-standard","has-post-thumbnail","category-business"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - 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