{"id":56499,"date":"2020-11-30T16:35:10","date_gmt":"2020-11-30T15:35:10","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/irb-barcelona-opens-new-lab-devoted-to-cellular-lineage-and-identity\/"},"modified":"2020-11-30T17:32:15","modified_gmt":"2020-11-30T16:32:15","slug":"irb-barcelona-opens-new-lab-devoted-to-cellular-lineage-and-identity","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/irb-barcelona-opens-new-lab-devoted-to-cellular-lineage-and-identity\/","title":{"rendered":"IRB Barcelona opens a new laboratory focused in the study of cell lineages and the regulation of cell identity"},"content":{"rendered":"

Alejo Rodr\u00edguez-Fraticelli\u00a0joins the\u00a0Institute for Research in Biomedicine (IRB Barcelona<\/a>) to head the Quantitative Stem Cell Dynamics<\/a> laboratory, that will focus in the study of cell lineages seeks to clarify how different types of cells are generated, a\u00a0research with important implications of this process for the development of an organism, as well as for cancer. With this new faculty member, the Institute, based in the Barcelona Science Park, will have 28 laboratories and 8 scientific platforms.<\/strong><\/p>\n

The cells of a living organism share the same DNA, the same instruction book, and yet each cell develops a unique identity.\u00a0Stem cells are characterised by their pluripotency, meaning the ability to give rise to different cell types. Indeed, this capacity is essential during development, when a single cell brings about an entire organism, and it is pivotal in cancer because it is the cancer stem cells that maintain that potential to regenerate a tumour after it has been removed, or to colonise other organs, in a process known as metastasis.<\/p>\n

With the aim to provide new therapeutic perspectives, cell lineage tracing allows the identities and fates of thousands of cells to be linked simultaneously, and also the prediction of those cells most likely to metastasize.<\/p>\n

“Our field of study is devoted to cell lineages and the regulation of cell identity, but above all,\u00a0 we will be a technology-driven laboratory, constantly focused on developing the next generation of genetic tools that allow us to answer more complex questions”, says\u00a0Rodr\u00edguez-Fraticelli, group leader of the new Quantitative Stem Cell Dynamics laboratory at IRB Barcelona.<\/p>\n

The career of Alejo Rodr\u00edguez-Fraticelli<\/strong><\/h3>\n

Rodr\u00edguez-Fraticelli (Buenos Aires, Argentina, 1985) studied Biology and then Biochemistry at the Autonomous University of Madrid and, from the very outset, he knew that he wanted to pursue a career in research. His first contact with the laboratory, on the recommendation of his immunology professor, scientist and science disseminator Jose Antonio Lopez Guerrero, was at the Severo Ochoa Center for Molecular Biology (CBMSO), in\u00a0 Miguel Angel Alonso\u2019s group.\u00a0 There, he learned the bases of molecular biology and microscopy by studying epithelial cells and lymphocytes. He did his doctoral thesis on epithelial biology, using 3D cell cultures\u2014organoids\u2014under the supervision of Fernando Mart\u00edn Belmonte, also at the CBMSO.<\/p>\n

In 2015,\u00a0Alejo Rodr\u00edguez-Fraticelli\u00a0took up a postdoctoral position in Fernando Camargo’s laboratory at Harvard University and Boston Children’s Hospital, where he specialised in single-cell technologies and the tracing of cell lineages in both development and cancer to understand the bases of cellular heterogeneity.\u00a0 “When I was interviewed by Fernando, it was as if someone opened the door to a world of biology that I didn’t know about,”\u00a0 says Rodr\u00edguez-Fraticelli, “he was clearly interested in the development and size of organs, but his mind went far beyond what I had ever thought and I knew straight away that I had to join that lab.”<\/p>\n

He has published more than 20 scientific articles, among these two in\u00a0Science\u00a0and\u00a0Nature\u00a0this year and in which he appears as first author.<\/p>\n

\u25ba For further information: <\/strong>IRB Barcelona website [+]<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Alejo Rodr\u00edguez-Fraticelli\u00a0joins the\u00a0Institute for Research in Biomedicine (IRB Barcelona) to head the Quantitative Stem Cell Dynamics laboratory, that will focus in the study of cell lineages seeks to clarify how…<\/p>\n","protected":false},"author":2,"featured_media":56491,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-56499","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"acf":[],"yoast_head":"\nIRB Barcelona opens a new laboratory focused in the study of cell lineages and the regulation of cell identity - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/irb-barcelona-opens-new-lab-devoted-to-cellular-lineage-and-identity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IRB Barcelona opens a new laboratory focused in the study of cell lineages and the regulation of cell identity - 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