{"id":50277,"date":"2015-01-22T00:00:00","date_gmt":"2015-01-21T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/a-further-step-towards-light-controlled-drugs\/"},"modified":"2015-01-22T00:00:00","modified_gmt":"2015-01-21T23:00:00","slug":"a-further-step-towards-light-controlled-drugs","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/a-further-step-towards-light-controlled-drugs\/","title":{"rendered":"A further step towards light-controlled drugs"},"content":{"rendered":"

Now, in recent experiments published in the journal\u00a0Chemistry & Biology\u00a0(doi: 10.1016\/j.chembiol.2014.10.022<\/a>),\u00a0the same researchers have been using their photo-sensitive molecules to control clathrin-mediated endocytosis, a process whereby cells absorb certain substances that they need to function properly. In doing so, they’ve made a discovery that greatly expands the field of potential inhibitors, as\u00a0 it questions the need for one of the previously supposed design requisites of these molecules.\u00a0<\/p>\n

They found that the absence of a rigid, helical structure, therefore, is not a limitation when selecting candidates for photoswitchable inhibitors of nhibition protein-protein interaction (PPIs), meaning that when developing further potential inhibitors, researchers can look to the wide group of more flexible peptides for their candidates.<\/p>\n

The most immediate therapeutic applications expected for photoswitchable inhibitors is for diseases affecting superficial tissue such as the skin, retina and external mucus membranes. In the future, photo-sensitive molecules could be used to study, for example,\u00a0in vitro\u00a0endocytosis in cancer cells \u2013 where this process is uncontrolled \u2013 which would allow selective inhibition of the cells’ proliferation.<\/p>\n","protected":false},"excerpt":{"rendered":"

Last year, a group of scientists at the Institute for Bioengineering of Catalonia (IBEC<\/a>), the Institute for Research in Biomedicine (IRB Barcelona<\/a>) \u2013based in the PCB\u2013 and the University of Barcelona (UB<\/a>) announced that\u00a0they had achieved photo-switchable, or light-regulated, molecules\u00a0to control protein-protein interactions \u2013 key determinants in biological processes, and therefore highly promising therapeutic targets \u2013 in a remote and non-invasive manner. The discovery signified a major step towards the development of targeted, light-controlled drugs, whose effects would be limited to a specific area and time, reducing side effects.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-50277","post","type-post","status-publish","format-standard","category-uncategorized"],"acf":[],"yoast_head":"\nA further step towards light-controlled drugs - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/a-further-step-towards-light-controlled-drugs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A further step towards light-controlled drugs - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Last year, a group of scientists at the Institute for Bioengineering of Catalonia (IBEC), the Institute for Research in Biomedicine (IRB Barcelona) \u2013based in the PCB\u2013 and the University of Barcelona (UB) announced that\u00a0they had achieved photo-switchable, or light-regulated, molecules\u00a0to control protein-protein interactions \u2013 key determinants in biological processes, and therefore highly promising therapeutic targets \u2013 in a remote and non-invasive manner. 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