{"id":50271,"date":"2015-09-14T00:00:00","date_gmt":"2015-09-13T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/ibec-group-presents-4th-generation-biomaterial-that-mimics-bone\/"},"modified":"2015-09-14T00:00:00","modified_gmt":"2015-09-13T23:00:00","slug":"ibec-group-presents-4th-generation-biomaterial-that-mimics-bone","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/ibec-group-presents-4th-generation-biomaterial-that-mimics-bone\/","title":{"rendered":"IBEC group presents 4th generation biomaterial that mimics bone"},"content":{"rendered":"

The researchers have published a paper in\u00a0Nanoscale\u00a0(10.1039\/C5NR04275E<\/a>)\u00a0elucidating a brand new biomaterial they\u2019ve created which paves the way towards a fourth generation of effective structures for tissue regeneration.(10.1039\/C5NR04275E<\/a>), aquesta nova marca de biomaterials que ells han creat i que prepara el cam\u00ed cap a la quarta generaci\u00f3 d\u2019estructures eficaces per a la regeneraci\u00f3 de teixits.<\/p>\n

\u201cUp to now, we\u2019ve been working with the third generation of biomaterials, which are resorbable and bioactive, but which often biodegrade in a non-homogeneous manner, as well as having biological responses which are far from ideal,\u201d explains Nad\u00e8ge Sachot, first author on the paper. \u201cWith this new material we\u2019re closer to the next generation, which would mimic natural tissues, recreating the molecular architecture and biochemical environment to surround cells with the proper stimuli to spread and grow.\u201d<\/p>\n

To make their hybrid material, the group took polylactic acid electrospun fibers and coated them with a bioactive, organically modified glass known as ormoglass. In comparison to fibers without the glass, the material showed improved hydrophilicity and mechanical properties, better bioactive ion release to aid angiogenesis, and exhibited a surface roughness that enabled good cell adhesion and spreading after just one day of culture.<\/p>\n

\u201cOur method of producing these materials is efficient, cost-effective and versatile,\u201d adds Nad\u00e8ge. \u201cWhat\u2019s more, we can easily modify their surface properties by changing the ormoglass composition, or transfer the protocol to other polymer structures prepared by different processing methods, so a wide range of biomaterials that could trigger different cellular responses could be produced for different applications.\u201d<\/p>\n

This offers the possibility to expand the material\u2019s application to additional tissue types depending on architecture and composition, such as an angiogenic coating for regeneration of muscles, or a tube coating for arterial replacement.<\/p>\n","protected":false},"excerpt":{"rendered":"

The Biomaterials for Regenerative Therapies <\/a>group at the\u00a0Institute for Bioengineering of Catalonia (IBEC<\/a>) \u2013located at the Barcelona Science Park (PCB)\u2013 and their collaborators at Wageningen University in the Netherlands and Warsaw University of Technology, Poland describe a hybrid material which faithfully mimics the structure of bone\u2019s extracellular matrix and which therefore offers the correct interactions between constituents to encourage cells to behave in the way required to successfully regenerate tissue.<\/p>\n

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