{"id":50251,"date":"2017-02-28T00:00:00","date_gmt":"2017-02-27T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/a-new-therapeutic-target-that-could-slow-the-progression-of-parkinsons-disease\/"},"modified":"2020-11-18T15:55:39","modified_gmt":"2020-11-18T14:55:39","slug":"a-new-therapeutic-target-that-could-slow-the-progression-of-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/a-new-therapeutic-target-that-could-slow-the-progression-of-parkinsons-disease\/","title":{"rendered":"A new therapeutic target that could slow the progression of Parkinson\u2019s disease"},"content":{"rendered":"<p>The researchers focused their study\u00a0\u2013\u00a0published this week\u00a0in\u00a0Molecular Neurobiology (<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s12035-017-0451-4\" target=\"_blank\" rel=\"noopener noreferrer\">doi:10.1007\/s12035-017-0451-4<\/a>)\u2013\u00a0on the cellular prion protein (PrPc), a specialized molecule located in the membranes of neurons that\u2019s involved in a number of functions such as cell cycle control and neurotransmission.<\/p>\n<p>In this work\u00a0they found that aside from carrying out these functions, PrPc\u00a0also binds to and increases the spreading of damaged \u03b1-synuclein \u2013 the protein responsible for neuronal degeneration and death in diseases such as Parkinson\u2019s \u2013 between neurons. This points to PrPc\u00a0as a possible pharmacological target to slow neurodegeneration in these types of pathologies.<\/p>\n<p>Parkinson\u2019s is a chronic neurodegenerative disease that affects movement. It develops when a particular type of neurons degenerate and die off, affecting the central nervous system\u2019s motor and cognitive functions. The culprits responsible for this degeneration are Lewy bodies, abnormal aggregates of a malignant version of \u03b1-synuclein, a protein found in the neuron\u2019s cytoplasm, that develop inside neurons.\u00a0<\/p>\n<p>\u201cPrPc\u00a0is a key player in the spreading of Lewy bodies,\u201d adds Jos\u00e9 Antonio Del R\u00edo, leader of\u00a0<a href=\"http:\/\/www.ibecbarcelona.eu\/neurobiotechnology\" target=\"_blank\" rel=\"noopener noreferrer\">one of the IBEC groups involved<\/a>\u00a0\u2013 the others were those of\u00a0<a href=\"http:\/\/www.ibecbarcelona.eu\/nanobioengineering\" target=\"_blank\" rel=\"noopener noreferrer\">Josep Samitier<\/a>\u00a0and E<a href=\"http:\/\/www.ibecbarcelona.eu\/bactinf\" target=\"_blank\" rel=\"noopener noreferrer\">duard Torrents<\/a>\u00a0\u2013 and coordinator of the study. \u201cIf we could prevent them from propagating and grouping to form these accumulations, we could stop the progression of neuronal death in diseases like Parkinson\u2019s.\u201d<\/p>\n<p>\u00a0<\/p>\n<p><strong>\u2022\u00a0Image description:<\/strong><em>\u00a0Left: a) Microfluidic device used in the study. Primary cortical neurons can be seen after 15 days in vitro. b)Immunolocalization of the malignant version of \u03b1-synuclein (green) growing in microfluidic devices after inoculation with recombinant \u03b1-synuclein. c) Photomicrograph showing examples of adult cortical neurons with relevant degenerated synuclein content 45 days after \u03b1-synuclein injection in the striatum.<\/em><br \/>\n\u00a0<\/p>\n<p>\u2022<strong>More information<\/strong>: <a href=\"http:\/\/www.ibecbarcelona.eu\/a-new-therapeutic-target-that-could-slow-the-progression-of-parkinsons-disease\/\">IBEC website [+]<\/a><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from <a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000134&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fes%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dibec%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">IBEC<\/a> at PCB have identified a potential way to slow down the neurodegenerative progression of Parkinson\u2019s disease.\u00a0This breakthrough \u2013a result of a collaboration of three research groups at IBEC together with colleagues in\u00a0the T\u00f2quio Metropolitan Institute of Medical Science, the\u00a0Bellvitge University Hospital (HUB), the\u00a0Vall d&#8217;Hebron Institute of Research (VHIR) and the Arag\u00f3n Institute for Engineering Research (I3A)\u2013\u00a0could also apply to other types of neurodegenerative diseases, including some types of dementia such as Alzheimer\u2019s disease, or multiple system atrophy.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":55903,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-50251","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - 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