{"id":50197,"date":"2017-08-11T00:00:00","date_gmt":"2017-08-10T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/two-studies-reject-the-scientific-dogma-associating-ageing-with-the-loss-of-stem-cell-circadian-rhythm\/"},"modified":"2020-11-18T15:23:48","modified_gmt":"2020-11-18T14:23:48","slug":"two-studies-reject-the-scientific-dogma-associating-ageing-with-the-loss-of-stem-cell-circadian-rhythm","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/two-studies-reject-the-scientific-dogma-associating-ageing-with-the-loss-of-stem-cell-circadian-rhythm\/","title":{"rendered":"Two studies reject the scientific dogma associating ageing with the loss of stem cell circadian rhythm"},"content":{"rendered":"<p>It is widely believed that, with the passage of time, stem cells cease to differentiate between day and night cycles, in other words they lose their circadian rhythm, and that this loss promotes ageing. However, this has been found not to be the case. Scientists from the IRB, UPF and UCi has discovered that\u00a0stem cells continue to show rhythmic activity but reprogram their circadian functions during ageing.<\/p>\n<p>\u201cAged stem cells conserve circadian rhythm but now perform another set of functions to tackle the problems that arise with age,\u201d\u00a0explains ICREA researcher\u00a0Salvador Aznar Benitah, head of the\u00a0<a href=\"https:\/\/www.irbbarcelona.org\/en\/research\/stem-cells-and-cancer\" target=\"_blank\" rel=\"noopener noreferrer\">Stem Cells and Cancer<\/a>\u00a0group and leader of the two studies. The scientists do not know how such reprogramming comes about.\u00a0Aznar Benitah\u00a0adds, \u201cthe problem is that as they age, stem cells lose the rhythmic functions necessary for tissue protection and maintenance, which become replaced by functions aimed at coping with stress.\u00a0Loss of the previous circadian functions of stem cells during natural ageing contributes in some way to greater damage and greater ageing\u201d.<br \/>\n\u00a0<\/p>\n<p><span style=\"font-size:16px\"><strong>A low-calorie diet keeps the circadian rhythm young \u00a0<\/strong><\/span><\/p>\n<p>\u00a0<\/p>\n<p>According to the researchers, their studies would explain why a calorie restriction diet slows down ageing.\u00a0\u201cThe low-calorie diet greatly contributes to preventing the effects of physiological ageing. Keeping the rhythm of stem cells \u201cyoung\u201d is important because in the end these cells serve to renew and preserve very pronounced day-night cycles in tissues. Eating less appears to prevent tissue ageing and therefore prevents stem cells from reprogramming their circadian activities,\u201d\u00a0explains\u00a0Aznar Benitah.<\/p>\n<p>According to the researchers, their studies would explain why a calorie restriction diet slows down ageing. What is not clear is whether low-calorie diets would keep ageing at bay in humans.\u00a0\u201cSuch diets are unlike to become widely followed because they entail constant hunger and so require a lot of willpower; also, such eating regimes provide the body with the minimum energy to perform its basic functions, which in the long term may have negative effects on people\u2019s everyday lives,\u201d\u00a0stresses\u00a0Aznar Benitah. The scientist explains that, in this regard, it is important to further examine why metabolism has such a dominant effect on the stem cell ageing process and, once the link that promotes or delays ageing has been identified, to develop treatments that can regulate this link.<br \/>\n\u00a0<\/p>\n<p><strong>\u25ba For further information:\u00a0<a href=\"https:\/\/www.irbbarcelona.org\/en\/news\/ageing-is-exacerbated-by-alterations-of-stem-cell-circadian-rhythm\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona website [+]<\/a><\/strong><\/p>\n<p>\u25ba <strong>Reference articles:<\/strong><br \/>\nSolanas, Guiomar et al. &#8220;<a href=\"http:\/\/www.cell.com\/cell\/abstract\/S0092-8674(17)30871-1\" target=\"_blank\" rel=\"noopener noreferrer\">Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Tissue-Specific Stress<\/a>&#8220;.\u00a0<em>Cell (2017).<\/em>\u00a0Doi: 10.1016\/j.cell.2017.07.035<\/p>\n<p>Sato, Shogo et al. &#8220;<a href=\"http:\/\/www.cell.com\/cell\/abstract\/S0092-8674(17)30878-4\" target=\"_blank\" rel=\"noopener noreferrer\">Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging<\/a>&#8220;.\u00a0<em>Cell\u00a0(2017).<\/em> Doi: 10.1016\/j.cell.2017.07.042<span style=\"font-family: heuristicaregular, arial, sans-serif;font-size: 15px\">\u00a0<\/span><\/p>\n<p>\u00a0<\/p>\n<p id=\"yui_patched_v3_11_0_1_1502442735504_222\">\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Two studies published in Cell by scientists from the Institute for Research in Biomedicine (<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000001&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dirb%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona<\/a>) at the Barcelona Science Park, the Pompeu Fabra University (<a href=\"https:\/\/www.upf.edu\/en\/web\/biomed\/inici\" target=\"_blank\" rel=\"noopener noreferrer\">UPF<\/a>)\u00a0and the\u00a0University of California, Irvine (<a href=\"https:\/\/uci.edu\/\" target=\"_blank\" rel=\"noopener noreferrer\">UCI<\/a>)\u00a0reject the scientific dogma associating ageing with the loss of stem cell circadian rhythm.\u00a0Their results reveal that\u00a0stem cell functions continue to be governed by day and night cycles (circadian rhythms) during ageing, but their rhythms become devoted to tissue repair and not to the maintenance of tissue tone.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":55708,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-50197","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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