{"id":50191,"date":"2016-07-20T00:00:00","date_gmt":"2016-07-19T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/vision-restoration-by-molecular-prostheses\/"},"modified":"2020-11-18T15:23:39","modified_gmt":"2020-11-18T14:23:39","slug":"vision-restoration-by-molecular-prostheses","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/vision-restoration-by-molecular-prostheses\/","title":{"rendered":"Vision restoration by molecular prostheses"},"content":{"rendered":"<p>Together with their collaborators at ICIQ, INA, CIBER-BBN and the Miguel Hern\u00e1ndez and Alcal\u00e1 de Henares universities, the researchers reveal in\u00a0Nature Communications\u00a0today their development of a new class of light-regulated drug, Targeted Covalent Photoswitches (TCPs), that act as prosthetic molecules that can restore photoresponses in degenerated retinas.<\/p>\n<p>Light-regulated drugs like the ones developed in recent years by IBEC researchers in Pau\u2019s\u00a0<a href=\"http:\/\/www.ibecbarcelona.eu\/nanoprobes\" target=\"_blank\" rel=\"noopener noreferrer\">Nanoprobes and Nanoswitches<\/a>\u00a0group can be photoswitched remotely \u2013 that is to say, their biological activity can be turned on and off using light. Now, the collaborators have achieved proteins from the neurons involved in vision that respond similarly to when they are under normal physiological conditions \u2013 in other words, they trigger a response when light is received. In this way, they could act as prosthetic molecules and restore the photoresponse of degenerating retinas.<\/p>\n<p>\u201cUnder normal conditions, the photoreceptor cells of the eye \u2013 the rods and cones \u2013 are those that react to receive light and activate, in turn, other retinal cells. We\u2019ve designed molecules that are activated by light: to receive light, they change shape, which modifies their interaction with neuronal receptors involved in sending visual signals to the brain,\u201d explains ICAQ\u2019s Amadeu Llebaria. \u201cThis first step demonstrates that the technique is possible; that these cells could replace the function of rods and cones when they are damaged.\u201d<\/p>\n<p>The molecules have been tested on the retinal tissues of blind mice, where they were observed to be activating the cells in the retina, which sent an electrical signal in response to receiving light. The\u00a0in vitro\u00a0tests were conducted by researchers from the Miguel Hernandez and Alcala de Henares universities.<\/p>\n<p>In this way, the research open the way towards revolutionary new therapies based on the controlled activity of small molecules \u2013 although it will be a while before this can be applied to real-world patients.<\/p>\n<p>\n<strong>Applications in different organisms<\/strong><\/p>\n<p>Until now, the type of molecules that can be photoswitched in endogenous receptors \u2013 those found naturally in the organism \u2013 have been photochromic ligands (PCLs), freely diffusible small molecules that act directly on these proteins. But they often display low specificity for their target, their remote control is limited to a narrow concentration range, and they are rendered less efficient by dilution in tissue. To avoid these drawbacks, photocontrol of these molecules can be confined to particular receptors; but this comes at the cost of genetic manipulation, which poses other limitations.<\/p>\n<p>To overcome these problems, the researchers developed a new chemical strategy to photoswitch protein activity that has the advantages of attachment to the target, but can be applied to endogenous proteins without requiring genetic manipulation.<\/p>\n<p>\u201cOur TCPs might work in a variety of organisms, including human, for which limited (opto)genetic manipulation techniques are currently available. This prospect makes the results on retina photosensitization especially appealing,\u201d says Pau Gorostiza of IBEC\/ICREA.<\/p>\n<p>This type of treatment, though far in the future, could help restore sensitivity to light and darkness with a drug. That would increase the quality of life for people with impaired vision due to retinal degeneration. \u201cCompared to currently available methods to restore retinal photoresponses such as retinal implants, our TCPs can help avoid surgery and providing better coupling to photostimulation than a physical device, as well as shortening rehabilitation by taking advantage of natural processing in the retina,\u201d concludes Pau.<\/p>\n<p>\n<strong>\u2022\u00a0Reference article:<\/strong>\u00a0\u00a0M. Izquierdo-Serra, A. Bautista-Barrufet, A. Trapero, A. Garrido-Charles, A. D\u00edaz-Tahoces, N. Camarero, S. Pittolo, S. Valbuena, A. P\u00e9rez-Jim\u00e9nez, M. Gay, A. Garc\u00eda-Moll, C. Rodr\u00edguez-Escrich, J. Lerma, P. de la Villa, E. Fern\u00e1ndez, M. \u00c0. Peric\u00e0s, Amadeu Llebaria, &amp; P. Gorostiza (2016).\u00a0<a href=\"http:\/\/www.nature.com\/ncomms\/2016\/160720\/ncomms12221\/full\/ncomms12221.html\" target=\"_blank\" rel=\"noopener noreferrer\">Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches.\u00a0<\/a>Nature Communications, epub ahead of print.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The groups of Pau Gorostiza, ICREA Research Professor in\u00a0<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000134&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dibec%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">IBEC<\/a> at PCB\u00a0and Amadeu Llebaria of <a href=\"http:\/\/www.iqac.csic.es\/index.php?lang=en\" target=\"_blank\" rel=\"noopener noreferrer\">IQAC-CSIC <\/a>have developed molecules that can be applied as light-regulated molecular prostheses to help restore vision in cases of retinal degeneration.\u00a0Marina Gay, Senior Research Officer in the <a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000001&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_tab%3D1%26_cercador_WAR_empleatsempresesportlet_keywords%3Dirb\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona<\/a>\u00a0Mass Spec &amp; Proteomics Facility at PCB, has also contributed to a study to develop molecular prostheses to restore sight.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":55684,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-50191","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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