{"id":50137,"date":"2016-11-10T00:00:00","date_gmt":"2016-11-09T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/new-boost-for-research-on-degenerative-retina-dystrophies\/"},"modified":"2020-11-18T15:19:39","modified_gmt":"2020-11-18T14:19:39","slug":"new-boost-for-research-on-degenerative-retina-dystrophies","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/new-boost-for-research-on-degenerative-retina-dystrophies\/","title":{"rendered":"New boost for research on degenerative retina dystrophies"},"content":{"rendered":"

Inherited Retinal Diseases (IRD) are hard to diagnose \u2013clinically and genetically- and provoke retinal degeneration and lead to blindness. Therefore, identifying a new gene is not only essential for its diagnosis but also to get inside the causes of the disease, set a prognostic, identify asymptomatic family members and monitor the affected ones.<\/p>\n

In the Faculty of Biology of the University of Barcelona, Professor Roser Gonz\u00e0lez directs the Consolidated Research Group of Functional Genomics, specialized on the study of genetic and molecular bases for eye diseases, especially degenerative retinal diseases. One of the research lines set up years ago by the team of Dr. Gonz\u00e0lez aims to identify new genes of this group of diseases and to optimize the genetic diagnose through techniques of massive exome sequencing and specific genomic panels. Moreover, the group has a distinguished scientific career on the functional study of new identified genes through the creation of cell and animal models to study in vivo and in vitro effects on mutant genes.<\/p>\n

The new scientific project entitled \u201cConstrucci\u00f3n de un nuevo modelo animal de retinosis pigmentaria y estudio de su utilidad para ensayos de terapias neuroprotectoras\u201d (Creation of a new animal model of pigmentary retinosis and study of its use in neuroprotective therapy tests), partially financially supported by ONCE, aims to create a mice model of DR through the CRISPR\/Cas9 genome editing system with\u00a0Cerkl\u00a0gene. As previous step to make the complete phenotype analysis, the project will characterize the neurophysiological and histological alterations in the animals\u2019 retina\u00a0in vivo<\/em>\u00a0and\u00a0in vitro<\/em>.\u00a0This phenotypic study is a previous requirement to assess its use as a tool for future neuroprotective tests on pharmacological, genic, or cell therapies.
\n\u00a0<\/p>\n

\u2022 For further information:\u00a0UB website [+]<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Creating an animal model for retinal dystrophies to make functional tests and open new therapy perspectives in these hereditary pathologies is the main objective of a new project driven by the University of Barcelona and ONCE, led by Professor Roser Gonz\u00e0lez, from the\u00a0Department of Genetics, Microbiology and Statistics<\/a>, and the\u00a0Institute of Biomedicine of the University of Barcelona (IBUB)<\/a>\u00a0at\u00a0PCB.<\/p>\n

\u00a0<\/p>\n","protected":false},"author":1,"featured_media":55486,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-50137","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"\nNew boost for research on degenerative retina dystrophies - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/new-boost-for-research-on-degenerative-retina-dystrophies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New boost for research on degenerative retina dystrophies - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Creating an animal model for retinal dystrophies to make functional tests and open new therapy perspectives in these hereditary pathologies is the main objective of a new project driven by the University of Barcelona and ONCE, led by Professor Roser Gonz\u00e0lez, from the\u00a0Department of Genetics, Microbiology and Statistics, and the\u00a0Institute of Biomedicine of the University of Barcelona (IBUB)\u00a0at\u00a0PCB. \u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pcb.ub.edu\/en\/new-boost-for-research-on-degenerative-retina-dystrophies\/\" \/>\n<meta property=\"og:site_name\" content=\"Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"article:published_time\" content=\"2016-11-09T23:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-18T14:19:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2016\/11\/16057091795fb52d7bd35a0.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"423\" \/>\n\t<meta property=\"og:image:height\" content=\"336\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"adminpcb\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"adminpcb\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/new-boost-for-research-on-degenerative-retina-dystrophies\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/new-boost-for-research-on-degenerative-retina-dystrophies\\\/\"},\"author\":{\"name\":\"adminpcb\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/d13cab05cd0a75b17fddca8496481021\"},\"headline\":\"New boost for research on degenerative retina dystrophies\",\"datePublished\":\"2016-11-09T23:00:00+00:00\",\"dateModified\":\"2020-11-18T14:19:39+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/new-boost-for-research-on-degenerative-retina-dystrophies\\\/\"},\"wordCount\":298,\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/new-boost-for-research-on-degenerative-retina-dystrophies\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2016\\\/11\\\/16057091795fb52d7bd35a0.jpeg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/new-boost-for-research-on-degenerative-retina-dystrophies\\\/\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/new-boost-for-research-on-degenerative-retina-dystrophies\\\/\",\"name\":\"New boost for research on degenerative retina dystrophies - 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