{"id":50053,"date":"2018-09-26T00:00:00","date_gmt":"2018-09-25T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/tumor-cell-expansion-challenges-current-physics\/"},"modified":"2020-11-18T15:14:42","modified_gmt":"2020-11-18T14:14:42","slug":"tumor-cell-expansion-challenges-current-physics","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/tumor-cell-expansion-challenges-current-physics\/","title":{"rendered":"Tumor cell expansion challenges current physics"},"content":{"rendered":"

A malignant tumor is characterized by its ability to spread around its surroundings. To do so, tumor cells stick to the surrounding tissue (mainly collagen) and use forces to propel.\u00a0<\/p>\n

Researchers put breast tumor cells on a surface rich in collagen and observed how these expanded. Thanks to the technology Trepat\u2019s group developed, these allowed them measuring the physical forces that were used by these cells during the process, which has not been observed so far. With these methods, they saw the tumor spreading depends on a competition between forces: cells stick to each other and are kept together, and at the same time, they adhere to the environment in order to escape. Depending on the predominant force, the tumor will keep its spherical shape or it will totally spread around the surface.<\/p>\n

These findings show the importance of physical forces in metastasis, opening the window to the development of therapies to alter the mechanics of tumors as a potential treatment.<\/p>\n

\n\u25ba For further information:\u00a0IBEC website [+]<\/a>\u00a0and\u00a0UB website [+]<\/a><\/strong><\/p>\n

\u25ba\u00a0Reference article:<\/strong>
\nCarlos P\u00e9rez-Gonz\u00e1lez, Ricard Alert, Carles Blanch-Mercader, Manuel G\u00f3mez-Gonz\u00e1lez, Tomasz Kolodziej, Elsa Bazellieres, Jaume Casademunt, Xavier Trepat (2018). “Active wetting of epithelial tissues<\/a>“.\u00a0Nature Physics, 2018.<\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

The journal Nature Physics published a study by a team led by Xavier Trepat, ICREA researcher at the Institute for Bioengineering of Catalonia (IBEC<\/a>) in\u00a0the Barcelona Science Park and lecturer at the Department of Biomedicine\u00a0University of Barcelona (UB<\/a>), and Jaume Casademunt, professor of Physics at the UB, reveals the forces these tumor cells use to spread. The relation between these forces and the cell movement goes beyond current physical laws.\u00a0<\/p>\n

\u00a0<\/p>\n","protected":false},"author":1,"featured_media":55165,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-50053","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"\nTumor cell expansion challenges current physics - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/tumor-cell-expansion-challenges-current-physics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tumor cell expansion challenges current physics - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"The journal Nature Physics published a study by a team led by Xavier Trepat, ICREA researcher at the Institute for Bioengineering of Catalonia (IBEC) in\u00a0the Barcelona Science Park and lecturer at the Department of Biomedicine\u00a0University of Barcelona (UB), and Jaume Casademunt, professor of Physics at the UB, reveals the forces these tumor cells use to spread. 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