{"id":50051,"date":"2017-10-24T00:00:00","date_gmt":"2017-10-23T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/an-increase-in-low-density-lipoproteins-would-favour-insulin-resistance\/"},"modified":"2020-11-18T15:14:42","modified_gmt":"2020-11-18T14:14:42","slug":"an-increase-in-low-density-lipoproteins-would-favour-insulin-resistance","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/an-increase-in-low-density-lipoproteins-would-favour-insulin-resistance\/","title":{"rendered":"An increase in low density lipoproteins would favour insulin resistance"},"content":{"rendered":"<p>Insulin is a hormone created by the pancreas which helps glucose to enter the cells and get energy. Insulin resistance is the condition in which normal amounts of this hormone are not enough to fulfil their role. This situation can cause type 2 diabetes, a chronic disease which, if not properly controlled, can cause problems in blood circulation, heart, eyes, kidneys and other organs.<\/p>\n<p>The study was conducted with mice muscular cells, which are part of the tissue that uses more glucose as a response to insulin, willing to check the impact of the VLDL increase on insulin resistance. \u201cSo far, we knew insulin resistance causes atherogenic dyslipidaemia, which starts due an increase of VLDL, and therefore triglycerides, which ends up causing a decrease of HDL cholesterol and of the smallest and most dense LDL cholesterol particles which are related to an increase of the risk of suffering from a cardiovascular disease. However, the effect of VLDL on insulin resistance was unknown\u201d, says Manuel V\u00e1zquez Carrera,\u00a0who is also\u00a0member of the Diabetes and Associated Metabolic Diseases Networking Biomedical Research Center (CIBERdem).\u00a0<\/p>\n<p>According to the researchers, this study shows the need to pay more attention to the increase of triglycerides in patients with diabetes, and it opens the door to designing more aggressive treatments in order to reduce those.\u00a0The next goal for the group is to prove in patients that this strategy which aims to reduce aggressively the triglycerides can delay or prevent the development of insulin resistance and type 2 diabete<\/p>\n<p>Researchers from the\u00a0<a href=\"http:\/\/www.bq.ub.es\/index_ing.php\" target=\"_blank\" rel=\"noopener noreferrer\">Department of Biochemistry and Molecular Biology<\/a>\u00a0of the UB, the Research Institute of the Hospital de la Santa Creu i Sant Pau (HSCSP-IR) and the University of Connecticut have also participated in the study.<\/p>\n<p><strong>\u25ba For further information:<a href=\"http:\/\/www.ub.edu\/web\/ub\/ca\/menu_eines\/noticies\/2017\/10\/032.html\" target=\"_blank\" rel=\"noopener noreferrer\">\u00a0<\/a><a href=\"http:\/\/www.ub.edu\/web\/ub\/en\/menu_eines\/noticies\/2017\/10\/032.html?\" target=\"_blank\" rel=\"noopener noreferrer\">UB website [+]<\/a><\/strong><\/p>\n<p><strong>\u25ba Reference article:<\/strong>\u00a0G. Botteri, M. Montori, A. Gum\u00e0, J. Pizarro, L. Ced\u00f3, J. C. Escol\u00e0-Gil, D. Li, E. Barroso, X. Palomer, A. B. Kohan, M. V\u00e1zquez-Carrera. &#8220;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28835988\" target=\"_blank\" rel=\"noopener noreferrer\">VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in mouse skeletal muscle cells<\/a>&#8220;.\u00a0Diabetologia, agost de 2017. Doi: https:\/\/doi.org\/10.1007\/s00125-017-4401-5<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study led by the University of Barcelona proved that low-density proteins (VLDL) can worsen insulin resistance, a disease that favours the development of type 2 diabetes.\u00a0The study, published in the scientific journal\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s00125-017-4401-5\" target=\"_blank\" rel=\"noopener noreferrer\">Diabetologia<\/a>\u00a0, has been carried out by the research group led by Manuel V\u00e1zquez Carrera, researcher from the\u00a0<a href=\"http:\/\/www.ub.edu\/farmaco\/en\/\" target=\"_blank\" rel=\"noopener noreferrer\">Department of Pharmacology, Toxicology and Therapeutic Chemistry<\/a>\u00a0and\u00a0the <a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_002730&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3DIBUB%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">Institute of Biomedicine\u00a0of the UB (IBUB)<\/a>,\u00a0located at the Barcelona Science Park.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":55157,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-50051","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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