{"id":50047,"date":"2018-12-05T00:00:00","date_gmt":"2018-12-04T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/proteins-can-transfer-electrons-at-a-distance\/"},"modified":"2020-11-18T15:12:08","modified_gmt":"2020-11-18T14:12:08","slug":"proteins-can-transfer-electrons-at-a-distance","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/proteins-can-transfer-electrons-at-a-distance\/","title":{"rendered":"Proteins can transfer electrons at a distance"},"content":{"rendered":"

The relocation of an electron from one chemical entity to another \u2013 electron transfer (ET) \u2013 doesn\u2019t happen passively: electrons are carried individually by redox proteins.<\/p>\n

The demands on the ET capabilities of these proteins are conflicting: their binding must be tight to keep ET rates high, but sufficiently weak to allow a high turnover rate and overall ET efficiency. As redox partners approach each other, an \u2018initial encounter\u2019 complex is formed that leads to a final \u2018active\u2019 complex \u2013 which is when ET was previously thought to happen.<\/p>\n

The structure of some active complexes between redox partner proteins has been revealed by X-ray crystallography, and substantial differences observed in the distance between the active sites of several has raised the question of whether ET between proteins can already occur while the protein is approaching its partner site. Together with collaborators from the UB and the University of Seville, the researchers in IBEC\u2019s\u00a0Nanobioengineering group<\/a>\u00a0worked with its\u00a0Nanoprobes and Nanoswitches group<\/a>\u00a0(led by Pau Gorostiza, right) to use a technique called electrochemical tunneling spectroscopy to show that the current between two redox partner proteins occurs at strikingly long distances.<\/p>\n

\u201cComputational simulations suggest proteins can manipulate the solution they\u2019re surrounded by in order to perform their ET functions,\u201d explains Anna Lagunas, a senior researcher in IBEC\u2019s Nanobioengineering group and first author of the paper. \u201cWe saw a reduced ionic density between the proteins that gives rise to a conduit that extends their electric field through the aqueous solution.\u201d<\/p>\n

\n\u25baMore information: Web de l’IBEC [+info<\/a>]<\/strong><\/p>\n

\u25baReference article:<\/strong>
\nA. Lagunas, A. Guerra\u2013Castellano, A. Nin Hill, I. Diaz Moreno, M. A. De la Rosa, J. Samitier, C. Rovira, P. Gorostiza (2018). Long distance electron transfer through the aqueous solution between redox partner proteins. Nature Communications, epub ahead of print.<\/p>\n

\u00a0<\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers from the Institute for Bioengineering of Catalonia (IBEC<\/a>) al PCB have published a study in\u00a0Nature Communications\u00a0that reveals that electron transfer can take place while a protein is approaching its partner site, and not only when the proteins are engaged, as was previously thought. The results open up a new way of thinking about how proteins interact, and can have implications in a better understanding of many processes \u2013 such as photosynthesis, respiration and detoxification \u2013 in which electron transfer plays an important role.<\/p>\n

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