{"id":50037,"date":"2016-12-07T00:00:00","date_gmt":"2016-12-06T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/tumour-cells-are-dependent-on-fat-to-start-metastasis\/"},"modified":"2020-11-18T15:11:43","modified_gmt":"2020-11-18T14:11:43","slug":"tumour-cells-are-dependent-on-fat-to-start-metastasis","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/tumour-cells-are-dependent-on-fat-to-start-metastasis\/","title":{"rendered":"Tumour cells are dependent on fat to start metastasis"},"content":{"rendered":"<p>The\u00a0study shows\u00a0that CD36 activity and dependence on lipid (fat) metabolism distinguish metastasis-initiating cells from other tumour cells.The researchers discovered the\u00a0metastatic CD36+ cells\u00a0in samples from patients with oral cancer with different degrees of aggressiveness, provided as part of a collaboration with the\u00a0Hospital Vall d\u2019Hebr\u00f3n de Barcelona. In the mouth tumours analysed, very few cells were found to have metastasis-initiating capacity. The addition of CD36 expression to tumours that did not cause metastasis made them become metastatic.<\/p>\n<p>Furthermore, the researchers have demonstrated that the effect exerted by CD36 on metastasis is the same for melanoma cells and luminal breast cancer cells. Likewise, statistical analyses of samples from patients reveal that the metastasis of ovarian, bladder and lung cancer are also dependent on CD36.<\/p>\n<p>\u201cAlthough we have not yet tested this in all tumour types,\u00a0we can state that CD36 is a general marker of metastatic cells, the first marker I know of that is generally specific to metastasis,\u201d\u00a0says\u00a0Salvador Aznar Benitah, head of the <a href=\"https:\/\/www.irbbarcelona.org\/en\/research\/stem-cells-and-cancer\" target=\"_blank\" rel=\"noopener noreferrer\">Stem Cell and Cancer Lab <\/a>at IRB Barcelona.\u00a0\u201cWe can now obtain metastatic cells in the laboratory.\u00a0This will allow us to trace them and to study, for example, their distribution in the tumour, where they anchor when they leave it, or why they are so sensitive to fat, among other questions,\u201d\u00a0adds the first author of the study\u00a0Gloria Pascual.<\/p>\n<p>Dr. Aznar-Benitah pointed that\u00a0\u201cWe expect this study to have a big impact on the scientific community\u00a0and to further advances in metastasis research, and we hope to be able to validate the potential of CD36 as an anti-metastasis treatment.\u00a0Things like this don\u2019t happen every day.\u201d<\/p>\n<p>IRB Barcelona has applied for IP protection of the results, and the researchers are working with MRC Technology in the UK to co-develop new antibody-based therapeutics against CD36 that are suitable for treatment of patients in a range of cancers. If the development of the novel therapeutic was successful, a new product could be available in 5-10 years.<\/p>\n<p><strong>\u25ba For further information<\/strong>\u00a0<a href=\"https:\/\/www.irbbarcelona.org\/en\/news\/tumour-cells-are-dependent-on-fat-to-start-metastasis\" style=\"font-weight: 200\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona website\u00a0[+]<\/a><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study headed by\u00a0Salvador Aznar Benitah,\u00a0ICREA researcher at the Institute for Research in Biomedicine (<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000001&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fen%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dirb%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona<\/a>) in the Barcelona Science Park, and published today in\u00a0Nature, identifies metastasis-initiating cells through a specific marker, namely the protein CD36.\u00a0Their results show that the protein CD36, which absorbs fat from the cell membrane, is an essential factor that determines whether tumour cells become metastatic.\u00a0IRB Barcelona will co-develop antibodies against CD36 with the potential to treat patients.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":55101,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-50037","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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