{"id":50036,"date":"2017-12-11T00:00:00","date_gmt":"2017-12-10T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/cells-sense-their-environment-to-explore-it\/"},"modified":"2020-11-18T15:11:42","modified_gmt":"2020-11-18T14:11:42","slug":"cells-sense-their-environment-to-explore-it","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/cells-sense-their-environment-to-explore-it\/","title":{"rendered":"Cells sense their environment to explore it"},"content":{"rendered":"<p>Interaction between cells and their ligands (or cell microenvironment) is essential to maintain the function of any tissue, and the detection of changes in the cell environment is in fact essential in all situations where there is tissue remodelling, such as the embryonic development, tumoral proliferation or the closing process of a wound.<\/p>\n<p>\u201cIn this research we determined how cells detect the position of molecules (or ligands) in their surroundings, with a nanometre precision\u201d, says Roca-Cusachs. \u201cWhen the ligands join \u2013he continues- cells apply a force they can detect. Since this force depends on the ligand spatial distribution, this enables cells to sense their surroundings. In some way, this would be the equivalent to recognizing someone\u2019s face in the dark by touching the face with your hand, instead of seeing that person\u201d.\u00a0<\/p>\n<p>In the study, researchers also saw how, \u201cdepending on this cell force distribution, it can affect the activation of genetic transcription, a phenomenon that determines which genes are expressed\u201d, says Roger Oria, first author of the study and PhD student at the UB in Dr Roca-Cusachs\u2019 laboratory.<\/p>\n<p>With this deeper knowledge of how cells detect their surroundings, researchers proved that by altering the conditions of the cell\u2019s environment (rigidity and distribution of those ligands that create the extracellular matrix) they can control the adherence response of the cell and they can even define a range in which the cell adheres, as well as the outside. This result, says Roca-Cusachs, can be certainly important in tumoral processes, since it is quite accepted for a greater rigidity to be related to a higher activation of oncogenes.\u00a0<\/p>\n<p>So far, researchers knew cells were able to perceive spatial and physical information at a nanoscale. In fact, it was thought for them to be able to \u201cmeasure distances\u201d and therefore people had hypotetized about the existence of some pattern molecule that could help in this process. According to the IBEC-UB researcher, this study opposes this hypothesis, since it shows that cells sense their surroundings more rather than seeing them.\u00a0<\/p>\n<p>\u25ba <b>More information: <a href=\"http:\/\/ibecbarcelona.eu\/cells-feel-their-environment-to-explore-it\/\" target=\"_blank\" rel=\"noopener noreferrer\">IBEC website [+]<\/a><\/b><\/p>\n<p>\u25ba\u00a0<strong>Reference article:\u00a0<\/strong><\/p>\n<p>Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, Jos\u00e9 Manuel Garc\u00eda-Aznar, Elisabetta Ada Cavalcanti-Adam i Pere Roca Cusachs.\u00a0<a href=\"https:\/\/www.nature.com\/articles\/nature24662\" target=\"_self\" rel=\"noopener noreferrer\">&#8220;Force loading explains spatial sensing of ligands by cells&#8221;<\/a>.\u00a0<em>Nature<\/em>, desembre del 2017. Doi:10.1038\/nature24662<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The way cells find their way around is by \u2018groping\u2019 rather than seeing their surroundings: this is the main conclusion of a study published in\u00a0Nature\u00a0last week involving several IBEC groups and their collaborators. The study was led by Pere Roca-Cusachs,\u00a0lecturer from the Department of Biomedicine and main researcher at the I<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000134&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dibec%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">nstitute for Bioengineering of Catalonia (IBEC)<\/a> at the Barcelona Science Park (PCB).<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":55097,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-50036","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cells sense their environment to explore it - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/cells-sense-their-environment-to-explore-it\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cells sense their environment to explore it - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"The way cells find their way around is by \u2018groping\u2019 rather than seeing their surroundings: this is the main conclusion of a study published in\u00a0Nature\u00a0last week involving several IBEC groups and their collaborators. 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