{"id":49988,"date":"2015-01-20T00:00:00","date_gmt":"2015-01-19T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/olga-torres-foundation-grants-funding-to-a-project-on-colon-cancer-at-irb-barcelona\/"},"modified":"2020-11-18T15:09:52","modified_gmt":"2020-11-18T14:09:52","slug":"olga-torres-foundation-grants-funding-to-a-project-on-colon-cancer-at-irb-barcelona","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/olga-torres-foundation-grants-funding-to-a-project-on-colon-cancer-at-irb-barcelona\/","title":{"rendered":"Olga Torres Foundation grants funding to a project on colon cancer at IRB Barcelona"},"content":{"rendered":"<p>One of the best-documented associations between chronic inflammation and tumorigenesis is colorectal cancer in patients that suffer from bowel inflammation.<\/p>\n<p>Given that one of the main functions of p38\u03b1 protein is the regulation of inflammatory mediators, the study of this kinase as a possible therapeutic target in tumour processes related to inflammation is highly attractive.<\/p>\n<p>Colorectal cancer is the third most common cancer worldwide. Patients with inflammatory bowel disease, both ulcerative colitis and Crohn&#8217;s colitis, are at increased risk of developing this type of cancer.<\/p>\n<p>In a recent article, \u00c1ngel R. Nebreda&#8217;s group described how p38\u03b1 is essential to maintain the health of the intestinal epithelium, regulate the severity of colitis, and act as a colon cancer suppressor.<\/p>\n<p>The principal objective of this project is to examine how p38\u03b1 regulates colorectal tumorigenesis associated with colitis. The results will unravel the role of p38\u03b1 and its effectors in the biology of cancer, as well as the interaction between epithelial cells and the tissue, with the aim to estimate its value as a therapeutic target or as a diagnostic indicator.<\/p>\n<p>This project has the potential to open up new perspectives of colorectal cancer associated with colitis and the possibility to consider p38\u03b1 MAPK signalling as a new therapeutic strategy.<\/p>\n<p>The Olga Torres Foundation (FOT), a non-profit private organisation, gives these\u00a0<a href=\"http:\/\/www.fundacionolgatorres.org\/becas_de_investigacion\/\" target=\"_blank\" rel=\"noopener noreferrer\">2-year grants<\/a>\u00a0to projects dedicated to the study of cancer and its relation with immunological alterations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Postdoctoral researcher Raquel Batlle, member of the Signalling and Cell Cycle Laboratory led by \u00c1ngel Rodr\u00edguez Nebreda at <a href=\"http:\/\/www.irbbarcelona.org\/en\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona<\/a>, will conduct a project called &#8220;Contribution of p38 MAPK signalling to colitis-associated colorectal tumorigenesis&#8221; over two years. This project has obtained one of the 60,000-\u20ac grants given by the\u00a0<a href=\"http:\/\/www.fundacionolgatorres.org\/\" target=\"_blank\" rel=\"noopener noreferrer\">Olga Torres Foundation<\/a>\u00a0in late 2014.<\/p>\n","protected":false},"author":1,"featured_media":54920,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49988","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Olga Torres Foundation grants funding to a project on colon cancer at IRB Barcelona - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/olga-torres-foundation-grants-funding-to-a-project-on-colon-cancer-at-irb-barcelona\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Olga Torres Foundation grants funding to a project on colon cancer at IRB Barcelona - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Postdoctoral researcher Raquel Batlle, member of the Signalling and Cell Cycle Laboratory led by \u00c1ngel Rodr\u00edguez Nebreda at IRB Barcelona, will conduct a project called &quot;Contribution of p38 MAPK signalling to colitis-associated colorectal tumorigenesis&quot; over two years. 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