{"id":49965,"date":"2020-04-27T00:00:00","date_gmt":"2020-04-26T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/bioengineering-contributes-to-new-advances-against-childhood-cancer\/"},"modified":"2020-11-18T15:09:09","modified_gmt":"2020-11-18T14:09:09","slug":"bioengineering-contributes-to-new-advances-against-childhood-cancer","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/bioengineering-contributes-to-new-advances-against-childhood-cancer\/","title":{"rendered":"Bioengineering contributes to new advances against childhood cancer"},"content":{"rendered":"

Neuroblastoma is the most frequent malignant tumor in the first year of life. It is caused by a genetic mutation from immature nerve cells (neuroblasts) that the fetus produces as part of its development process. It appears more frequently in and around the adrenal glands, but it can also occur in other areas of the abdomen and in the chest, neck and near the spine.\u00a0<\/p>\n

Now, researchers from the Institute for Bioengineering of Catalonia (IBEC), the INCLIVA Health Research Institute and the Hospital\u00a0Cl\u00ednico\u00a0de Valencia have made further headway in understanding how these tumors evolve by discovering how the rigidity of the tumor extracellular matrix affects the aggressiveness of\u00a0neuroblastoma.\u00a0<\/p>\n

The details of this investigation can be found in an article published this month in the journal\u00a0Scientific Reports\u00a0signed by a group of experts including\u00a0Josep\u00a0Samitier, the director of IBEC and head of the Institute\u2019s\u00a0Nanobioengineering\u00a0Group.\u00a0<\/p>\n

Previous studies indicated that the quantity and arrangement of the different elements of the tumor microenvironment could be associated with the aggressiveness of the\u00a0neuroblastoma, modifying its rigidity. These works suggested that stiffer extracellular matrices generate more aggressive tumor behavior, which motivated the authors of the work published now to focus the new research addressing the stiffness of the matrix in a simple and generic way.\u00a0<\/p>\n

To carry out the study, the researchers used a three-dimensional model obtained through 3D printing capable of generating different levels of stiffness to recreate simplified versions of tumors. Thanks to this new technology, the experts were able to see how the biomechanical properties of the tumor extracellular matrix affected the evolution of\u00a0neuroblastoma.\u00a0<\/p>\n

The results of this work show that the stiffer matrices favor the adaptation and growth of the most aggressive cells over time, which proves that the rigidity of the tumor extracellular membrane plays a key role in tumor development. Furthermore, this opens the door to future therapeutic trials aimed at blocking cellular interaction with the\u00a0components\u00a0that confer rigidity to the tumor extracellular matrix.\u00a0<\/p>\n

Future research will increase the complexity of the models by introducing on them\u00a0stromal\u00a0cells, which are non-tumor cells that make up structural tissue around the tumor cells.\u00a0<\/p>\n

\u25ba Reference article:<\/strong> Ezequiel Monferrer, Susana Mart\u00edn-Va\u00f1\u00f3, Aitor Carretero, Andrea Garc\u00eda-Lizarribar, Rebeca Burgos-Panadero, Samuel Navarro, Josep Samitier & Rosa Noguera. “A three-dimensional bioprinted model to evaluate the effect of stiffness on neuroblastoma cell cluster dynamics and behavior<\/a>“. DOI: https:\/\/doi.org\/10.1038\/s41598-020-62986-w<\/p>\n

\u25ba For further information<\/strong>: IBEC website [+]<\/a><\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers from the Institute for Bioengineering of Catalonia (IBEC<\/a>) at the Barcelona Science Park, the INCLIVA Health Research Institute and the Hospital Cl\u00ednico de Valencia have discovered how the rigidity of the tumor extracellular matrix affects the aggressiveness of neuroblastoma, a cancerous tumor that affects mainly children. The study, published in Scientific Reports, opens the door to generate more accurate models to predict tumor development in patients and to work in the design of new treatments.<\/p>\n

\u00a0<\/p>\n","protected":false},"author":1,"featured_media":54844,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49965","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"\nBioengineering contributes to new advances against childhood cancer - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/bioengineering-contributes-to-new-advances-against-childhood-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bioengineering contributes to new advances against childhood cancer - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Researchers from the Institute for Bioengineering of Catalonia (IBEC) at the Barcelona Science Park, the INCLIVA Health Research Institute and the Hospital Cl\u00ednico de Valencia have discovered how the rigidity of the tumor extracellular matrix affects the aggressiveness of neuroblastoma, a cancerous tumor that affects mainly children. 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