{"id":49961,"date":"2015-09-15T00:00:00","date_gmt":"2015-09-14T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/a-technique-dating-back-to-1935-is-recovered-for-cancer-research-in-flies\/"},"modified":"2020-11-18T15:09:01","modified_gmt":"2020-11-18T14:09:01","slug":"a-technique-dating-back-to-1935-is-recovered-for-cancer-research-in-flies","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/a-technique-dating-back-to-1935-is-recovered-for-cancer-research-in-flies\/","title":{"rendered":"A technique dating back to 1935 is recovered for cancer research in flies"},"content":{"rendered":"

In 2002,\u00a0Cayetano Gonz\u00e1lez, head of the\u00a0Cell Division<\/a>\u00a0lab at IRB Barcelona, faced a major technical problem with respect to research into tumour growth in\u00a0Drosophila, namely the limitless growth of malignant tumours, which kill the fly. The solution seemed straightforward\u2014tumour transplants, a common technique used in cancer research in mammals, including humans, which involves the transplantation of the tumour mass to mice. With over a century of research into the fly, it was hoped that the many tools available for this model would include one for tissue transplants. \u201cAnd this was indeed the case, but the articles devoted to methodologies were few and incomplete and therefore reproducing the technique in the lab was very complicated,\u201d explains Professor\u00a0Gonz\u00e1lez.<\/p>\n

Developed in 1935, the technique was used extensively in the following decades and then fell into disuse and practically disappeared towards the end of the last century. \u201cIn 2002, only a small number of researchers worldwide were aware of the existence of the technique,\u201d he says. Professor\u00a0J\u00e1nos Szabad, from the University of Szeged, in Hungary, was one of the few who continued to use the method and he invited Gonz\u00e1lez to visit his lab to learn about it. Since then,\u00a0Gonz\u00e1lez\u00a0has used this approach in his research into cancer models in flies, and his lab has trained scientists from centres in Europe, the US, India and Australia about its implementation.<\/p>\n

The article\u00a0(doi:10.1038\/nprot.2015.096<\/a>),\u00a0written by\u00a0Fabrizio Rossi, postdoctoral fellow at IRB Barcelona, and\u00a0Cayetano Gonz\u00e1lez, describes the materials, equipment, and methods required to implement the procedure rapidly and efficiently and provides links to videos that show each step of the process.<\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

A study conducted by ICREA researcher\u00a0Cayetano Gonz\u00e1lez, at the Institute for Research in Biomedicine (IRB Barcelona), and published in\u00a0Nature Protocols,\u00a0describes a forgotten technique used in the fly\u00a0Drosophila melanogaster<\/em>\u00a0dating back 80 years. This method allows the transplantation of tissue from larvae to adult flies, thus allowing research into tumour growth and other biological processes of biomedical interest, such as tissue regeneration.<\/p>\n

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