{"id":49888,"date":"2016-02-15T00:00:00","date_gmt":"2016-02-14T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/"},"modified":"2020-11-18T15:06:57","modified_gmt":"2020-11-18T14:06:57","slug":"irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/","title":{"rendered":"IRB researchers identify compounds that may open new paths to treat cancer"},"content":{"rendered":"<p>At present, there is a monoclonal antibody\u00a0 used in chemotherapy that interferes with the EGFR receptor\u00a0preventing coupling to the EGF protein. However,\u00a0tumor cells fail to generate resistance and treatment stops being effective in many cancer patients. There is nothing on the market that attacks EGF, and, in their quest for a compound, IRB Barcelona scientists have made a first step towards solving this problem. In a study of cancer cells <em>in vitro<\/em>, investigators present a number of peptides, small proteins, which bind to the EGF protein, thereby preventing interaction with its receptor.<\/p>\n<p>&#8220;Through this study we have been able to show that the said protein is very elusive and promiscuous in the forms it takes. It\u00a0is a viable target for targeted drug therapy. It should also be noted that we still do not have compounds that are powerful enough that would enable us to run studies on animal models. But we taken the first step and have opened a new path&#8221;, says <strong>Ernest Giralt<\/strong>, head of the laboratory and co-leader of the study, together with <strong>Laura Nevola<\/strong>, associate researcher at his lab. \u00a0<\/p>\n<p>\u00a0<\/p>\n<p>More information at <a href=\"https:\/\/www.irbbarcelona.org\/en\/news\/promising-compounds-against-a-cancer-target\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona website<\/a>.<\/p>\n<p>\u00a0\u00a0<\/p>\n<p>\u00a0\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The <a href=\"http:\/\/www.irbbarcelona.org\/en\/research\/design-synthesis-and-structure-of-peptides-and-proteins\" target=\"_blank\" rel=\"noopener noreferrer\">Peptides and Proteins Research Lab <\/a>\u00a0led by Dr. Ernest Giralt at the<em> <\/em>Institut de Recerca Biom\u00e8dica (IRB Barcelona) started three years ago to design compounds which prevented the binding between the Epidermal Growth Factor (EGF) protein and its\u00a0 EGFR receptor. The interaction between these two proteins accelerates the metabolism of tumor cells in order for them to grow and divide faster.<\/p>\n","protected":false},"author":1,"featured_media":54576,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49888","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IRB researchers identify compounds that may open new paths to treat cancer - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IRB researchers identify compounds that may open new paths to treat cancer - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"The Peptides and Proteins Research Lab \u00a0led by Dr. Ernest Giralt at the Institut de Recerca Biom\u00e8dica (IRB Barcelona) started three years ago to design compounds which prevented the binding between the Epidermal Growth Factor (EGF) protein and its\u00a0 EGFR receptor. The interaction between these two proteins accelerates the metabolism of tumor cells in order for them to grow and divide faster.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"article:published_time\" content=\"2016-02-14T23:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-18T14:06:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2016\/02\/16057084185fb52a8228a16.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"350\" \/>\n\t<meta property=\"og:image:height\" content=\"182\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"adminpcb\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"adminpcb\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/\"},\"author\":{\"name\":\"adminpcb\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/d13cab05cd0a75b17fddca8496481021\"},\"headline\":\"IRB researchers identify compounds that may open new paths to treat cancer\",\"datePublished\":\"2016-02-14T23:00:00+00:00\",\"dateModified\":\"2020-11-18T14:06:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/\"},\"wordCount\":203,\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2016\\\/02\\\/16057084185fb52a8228a16.jpeg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/\",\"name\":\"IRB researchers identify compounds that may open new paths to treat cancer - Parc Cient\u00edfic de Barcelona\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2016\\\/02\\\/16057084185fb52a8228a16.jpeg\",\"datePublished\":\"2016-02-14T23:00:00+00:00\",\"dateModified\":\"2020-11-18T14:06:57+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/d13cab05cd0a75b17fddca8496481021\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2016\\\/02\\\/16057084185fb52a8228a16.jpeg\",\"contentUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2016\\\/02\\\/16057084185fb52a8228a16.jpeg\",\"width\":350,\"height\":182},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"IRB researchers identify compounds that may open new paths to treat cancer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#website\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/\",\"name\":\"Parc Cient\u00edfic de Barcelona\",\"description\":\"Universitat de Barcelona\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/d13cab05cd0a75b17fddca8496481021\",\"name\":\"adminpcb\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/41ad0fab4bb3bf5348b0af9612159cfd93173a57bbca98fecb50fa6f3ab97d28?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/41ad0fab4bb3bf5348b0af9612159cfd93173a57bbca98fecb50fa6f3ab97d28?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/41ad0fab4bb3bf5348b0af9612159cfd93173a57bbca98fecb50fa6f3ab97d28?s=96&d=mm&r=g\",\"caption\":\"adminpcb\"},\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/author\\\/adminpcb\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"IRB researchers identify compounds that may open new paths to treat cancer - Parc Cient\u00edfic de Barcelona","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/","og_locale":"en_US","og_type":"article","og_title":"IRB researchers identify compounds that may open new paths to treat cancer - Parc Cient\u00edfic de Barcelona","og_description":"The Peptides and Proteins Research Lab \u00a0led by Dr. Ernest Giralt at the Institut de Recerca Biom\u00e8dica (IRB Barcelona) started three years ago to design compounds which prevented the binding between the Epidermal Growth Factor (EGF) protein and its\u00a0 EGFR receptor. The interaction between these two proteins accelerates the metabolism of tumor cells in order for them to grow and divide faster.","og_url":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/","og_site_name":"Parc Cient\u00edfic de Barcelona","article_published_time":"2016-02-14T23:00:00+00:00","article_modified_time":"2020-11-18T14:06:57+00:00","og_image":[{"width":350,"height":182,"url":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2016\/02\/16057084185fb52a8228a16.jpeg","type":"image\/jpeg"}],"author":"adminpcb","twitter_card":"summary_large_image","twitter_misc":{"Written by":"adminpcb","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/#article","isPartOf":{"@id":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/"},"author":{"name":"adminpcb","@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/d13cab05cd0a75b17fddca8496481021"},"headline":"IRB researchers identify compounds that may open new paths to treat cancer","datePublished":"2016-02-14T23:00:00+00:00","dateModified":"2020-11-18T14:06:57+00:00","mainEntityOfPage":{"@id":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/"},"wordCount":203,"image":{"@id":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2016\/02\/16057084185fb52a8228a16.jpeg","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/","url":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/","name":"IRB researchers identify compounds that may open new paths to treat cancer - Parc Cient\u00edfic de Barcelona","isPartOf":{"@id":"https:\/\/www.pcb.ub.edu\/es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/#primaryimage"},"image":{"@id":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2016\/02\/16057084185fb52a8228a16.jpeg","datePublished":"2016-02-14T23:00:00+00:00","dateModified":"2020-11-18T14:06:57+00:00","author":{"@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/d13cab05cd0a75b17fddca8496481021"},"breadcrumb":{"@id":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/#primaryimage","url":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2016\/02\/16057084185fb52a8228a16.jpeg","contentUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2016\/02\/16057084185fb52a8228a16.jpeg","width":350,"height":182},{"@type":"BreadcrumbList","@id":"https:\/\/www.pcb.ub.edu\/en\/irb-researchers-identify-compounds-that-may-open-new-paths-to-treat-cancer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.pcb.ub.edu\/en\/"},{"@type":"ListItem","position":2,"name":"IRB researchers identify compounds that may open new paths to treat cancer"}]},{"@type":"WebSite","@id":"https:\/\/www.pcb.ub.edu\/es\/#website","url":"https:\/\/www.pcb.ub.edu\/es\/","name":"Parc Cient\u00edfic de Barcelona","description":"Universitat de Barcelona","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pcb.ub.edu\/es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/d13cab05cd0a75b17fddca8496481021","name":"adminpcb","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/41ad0fab4bb3bf5348b0af9612159cfd93173a57bbca98fecb50fa6f3ab97d28?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/41ad0fab4bb3bf5348b0af9612159cfd93173a57bbca98fecb50fa6f3ab97d28?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/41ad0fab4bb3bf5348b0af9612159cfd93173a57bbca98fecb50fa6f3ab97d28?s=96&d=mm&r=g","caption":"adminpcb"},"url":"https:\/\/www.pcb.ub.edu\/en\/author\/adminpcb\/"}]}},"_links":{"self":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts\/49888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/comments?post=49888"}],"version-history":[{"count":1,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts\/49888\/revisions"}],"predecessor-version":[{"id":54575,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts\/49888\/revisions\/54575"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/media\/54576"}],"wp:attachment":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/media?parent=49888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/categories?post=49888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/tags?post=49888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}